Self-Assembly of Unlike Homopolymers into Hollow Spheres in Nonselective Solvent

Duan, Hongwei; Chen, Daoyong; Jiang, Ming; Gan, Wenjun; Li, Shanjun; Wang, Min; Gong, Jie

doi:10.1021/ja011502v

Cited by 153 publications

(144 citation statements)

References 21 publications

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“…The D h of hollow spheres decreased with the increasing of PEG content in CS-g-PEG, which indicated that more grafts favor the formation of smaller aggregates. This tendency of the size varying with "graft density" is quite consistent with that reported for the hydrogen bonding graft complexes in solvent (Chen & Jiang, 2005;Duan & Chen, 2001;Duan et al, 2004;Kuang, Duan, Wang, Chen, & Jiang, 2003;Kuang et al, 2004). In that case, the rod-like rigid polymer "grafting" to the coil-like polymer chains through hydrogen bonding led to the formation of submicron hollow sphere with rod polymer as the inner shell and coil polymer as the outer shell .…”

Section: Preparation Of Chckgm Conjugatessupporting

confidence: 85%

“…As a result, the CS-g-PEG/␣-CD complexes have both rod block (PEG-␣-CD inclusion) and coil block (ionized CS backbone). Jenekhe et al and Jiang et al have reported that the rod-like block in rod-coil system preferred parallel packing crowdedly and resulted in the formation of hollow spheres for necessary of the efficient spacefilling packing (Chen & Jiang, 2005;Duan & Chen, 2001;Duan et al, 2004;Harada et al, 1993;Huang et al, 1998;Jenekhe & Chen, 1998; Jenekhe & Chen, 1999;Kuang et al, 2003Kuang et al, , 2004 With the formation of insoluble PEG-␣-CD inclusion blocks, water became a selective solvent for the CS-g-PEG/␣-CD, so hollow spheres were formed. The expected structure of such an aggregate in aqueous solution is an inner PEG-␣-CD inclusion block surrounded by the protonated coil-like CS shell.…”

Section: Preparation Of Chckgm Conjugatesmentioning

confidence: 99%

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Synthesis of biocompatible hybrid magnetic hollow spheres based on encapsulation strategy

et al. 2013

Carbohydrate Polymers

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Section: Preparation Of Chckgm Conjugatessupporting

confidence: 85%

Section: Preparation Of Chckgm Conjugatesmentioning

confidence: 99%

Synthesis of biocompatible hybrid magnetic hollow spheres based on encapsulation strategy

et al. 2013

Carbohydrate Polymers

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“…One kind of the targeting materials is hollow spherical aggregates, which have great potential for encapsulation of large quantities of guest molecules or large sized guests within the "empty" core domain [2]. Since Jenekhe and Chen reported that rigid-coil copolymers could selfassemble to hollow spheres directly in their selective solvent [3], over the last 10 years, this novel approach aroused many researcher's interest in using rigid-coil systems to construct hollow spheres [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, polyglycerols have been derivatized by different functional groups and molecules in order to produce polymers with unique properties. For example, alkylated dendritic, branched, and star-shape polyglycerols can H-bond with various substrates and thus be used to dissolve hydrophilic compounds in apolar media [3][4][5]. In this study, we have synthesized and characterized aminated polyglycerols from linear and star-shape PGMA.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular assembly of cyclodextrin-based nanospheres for gene delivery

Fan

Xi-Zhang

et al. 2011

Journal of Controlled Release

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“…As shown in Figure 1a, the particles had round outline shape with diameter of about 500 nm and the cores of particles were a little brighter than the outlines of the particles, which was a typical TEM image of hollow spheres as reported for different kinds of hollow particles. [13][14][15][16][17][18]22 After addition of GOD to the solution during the process of self-assembly of CS-g-PEGM and α-CD, the enzymes were entrapped in the CS-g-PEGM/α-CD hollow spheres. The isoelectric point of GOD and CS was around 4.2 and 6.3, respectively, 25 therefore the pH of mixture was adjusted to 6.8 to make sure that the GODs could not absorb on CS-g-PEGM through electrostatic interaction.…”

mentioning

confidence: 99%

Cyclodextrin-Based Microcapsules as Bioreactors for ATP Biosynthesis

Jian-hu

Wang

et al. 2013

Biomacromolecules

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A biomimetic energy converter was fabricated via the assembly of CF 0 F 1 -ATPase on lipid-coated hollow nanocapsules composed of α-cyclodextrins/ chitosan-graf t-poly(ethylene glycol) methacrylate. Upon entrapped GOD into these capsules, the addition of glucose could trigger proton-motive force and then drive the rotation of ATPase to synthesize ATP.L iving organisms make a series of metabolisms every moment. An organism that wants to maintain activities needs a continuous supply of energy: adenosine triphosphate (ATP). As the energy currency, ATP induces large conformational changes in molecules such as myosin, kinesin, and chaperonin. With inspiration from biology, biological and biomimetic devices that supply ATP as energy, such as molecular motors and artificial cell bioreactors, have been developed. 1−4 However, in motility and functionality assays reported on these devices, the issue of ATP regulation is usually sidestepped by supplying ATP externally into the buffer solution. Complications can occur as high concentrations of ATP, and the devices stop operation when all the ATP runs out. For the long-term operation of more complex molecular devices, continual supply of the right amount of ATP is required.The enzyme primarily responsible for the production of ATP is the F 1 F 0 -type ATPase, which synthesizes ATP from adenosine diphosphate (ADP) and inorganic phosphate (Pi) by utilizing proton gradients. 5 Several groups have been working on the reconstitution of ATPase in liposomes as biomimetic systems to carry out ATP biosynthesis. 6−8 Although they have excellent assay characteristics, the future applicability of liposomes is intrinsically limited due to chemical and mechanical weaknesses. In order to get more stable and robust biomimetic membranes, polymersome and lipid bilayercoated microcapsules have been developed replacing traditional liposomes very recently. 9−12 For instance, Choi et al. demonstrated that synthesized amphiphilic polymersomes can replace liposomes for ATP synthesis. However, the synthesis needs strict control, and the assembled vesicles were not sufficiently stable. Li et al. introduced microcapsules fabricated by the layer-by-layer (LBL) assembly technique into the biomimetic system design and fabricated a series of biomimetic energy converters via the assembly of ATPase on lipid-coated hollow microcapsules. However, this strategy requires a procedure to remove the core in order to create a hollow interior and needs multiple steps to produce the wall of the microcapsules.In our previous study, we reported that polymeric hollow spheres with semipermeability could be obtained directly by self-assembly of rod−coil copolymers/cyclodextrin (CD) complexes in analogy to the cell membrane. 13−18 In the present work, we utilized this self-assembly approach to design a new type of biomimetic capsules for ATP synthesis. This capsule comprised a self-assembled hollow sphere as the inner support and its absorbed lipid as the out layer. Furthermore, glucose oxidases (GODs) were ent...

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Self-Assembly of Unlike Homopolymers into Hollow Spheres in Nonselective Solvent

Cited by 153 publications

References 21 publications

Synthesis of biocompatible hybrid magnetic hollow spheres based on encapsulation strategy

Synthesis of biocompatible hybrid magnetic hollow spheres based on encapsulation strategy

Supramolecular assembly of cyclodextrin-based nanospheres for gene delivery

Cyclodextrin-Based Microcapsules as Bioreactors for ATP Biosynthesis

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