Self-assembly of reverse poloxamine induced by saccharide excipients: Insights from fluorescence

Detailed Study on the Interfacial Interaction between Different Polyoxometalates and Tetronic Block Copolymers Exploring the Langmuir–Blodgett Technique

“…1 H NMR study of pure T90R4 alone was performed with 1 × 10 –3 M T90R4 at 25 °C (curve 1, Figure S1). It was previously reported by Kumar et al at 25 °C T90R4 remains in monomer form up to a concentration of 6.94 × 10 –3 M . The sharp singlet at 3.6 ppm was identified as −CH 2 protons from PEO groups, the doublet at 3.45 ppm was for CH 2 protons from PPO groups, and the doublet at 1.05 ppm was for −CH 3 protons from PPO groups (curve 1, Figure S1).…”

“…1 H NMR study of pure T90R4 alone was performed with 1 × 10 −3 M T90R4 at 25 °C (curve 1, Figure S1). It was previously reported by Kumar et al at 25 °C T90R4 remains in monomer form up to a concentration of 6.94 × 10 −3 M. 62 The sharp singlet at 3.6 ppm was identified as −CH 2 protons from PEO groups, the doublet at 3.45 ppm was for CH 2 protons from PPO groups, and the doublet at 1.05 ppm was for −CH 3 protons from PPO groups (curve 1, Figure S1). 38 In the presence of PTA with increasing concentration (curves 2 and 3, Figure S1) the peak positions of −CH 2 and −CH 3 protons from PPO groups recorded a higher chemical shift, whereas the peak position for −CH 2 protons from PEO groups remained unaffected, which suggested that PTA was selectively bound to the PPO part over PEO.…”

Additive-anchored thermoresponsive nanoscale self-assembly generation in normal and reverse Tetronics®

“…The obtained CP results tie in well with the literature values. 10,38,47 Also, in the case of 10 w/v% T90R4, the CP declined from ∼50 °C to ∼33 °C and ∼35 °C up to 4 M glucose and sorbitol, respectively. These additives compete with the water molecules accompanying the micelle, resulting in hydrogen bond disruption and generating a salting out effect, thereby leading to the dehydration of the Tetronics® micelle surface.…”

“…Several reports on the influence of sugars on BCP micelles have been put forth that support our findings. 13,47–49…”

“…Several reports on the influence of sugars on BCP micelles have been put forth that support our findings. 13,[47][48][49] In Fig. 3d, 10 w/v% T904 with 2 M NaCl demonstrates an increase in D h from B 15 nm at 30 1C to B40 nm at 40 1C, owing to a micellar growth and of 4100 nm at B50 1C (high micellar growth due to CP proximity portraying the existence of spherical micelles).…”