Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Lv, Runkai; Qian, Zhengzheng; Zhao, Xiaopeng; Xiong, Fei; Ye, Xu; Fan, Wenpei; Yao, Xikuang; Huang, Wei

doi:10.1007/s12274-022-5184-7

Cited by 6 publications

(8 citation statements)

References 44 publications

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“…The ATP, CRT, and HMGB-1 enzyme-linked immunosorbent assay (ELISA) kits were purchased from Beyotime (Shanghai, China). Sar-NCA was synthesized according to our previous report . All other biochemical reagents were purchased from Sigma-Aldrich and used without any other purification process.…”

Section: Materials and Experimental Proceduresmentioning

confidence: 99%

“…Sar-NCA was synthesized according to our previous report. 26 All other biochemical reagents were purchased from Sigma-Aldrich and used without any other purification process. All animal experiments were carried out in accordance with ethical regulations and were approved by the Animal Experimentation Facility of the Chinese University of Pharmacy and Pharmaceutical Sciences.…”

Section: Materials and Experimental Proceduresmentioning

confidence: 99%

“…25 Intriguingly, our group observed that PSardecorated gold nanovesicles exhibited higher cell uptake efficiency and superior antitumor efficacy compared to their PEGylated counterparts. 26 Thus, through the strategic utilization of PSar decoration (PSarylation), ICD inducers are expected to be precisely delivered to tumors and exhibit a superior anticancer effect. However, a comprehensive investigation into the differential effects of ICD between PEGylation and PSarylation remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

“…Herth and co-workers revealed that PSar improved the reaction kinetics of tetrazine ligation for efficient nuclear imaging . Intriguingly, our group observed that PSar-decorated gold nanovesicles exhibited higher cell uptake efficiency and superior antitumor efficacy compared to their PEGylated counterparts . Thus, through the strategic utilization of PSar decoration (PSarylation), ICD inducers are expected to be precisely delivered to tumors and exhibit a superior anticancer effect.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polysarcosine as PEG Alternative for Enhanced Camptothecin-Induced Cancer Immunogenic Cell Death

Yao,

Sun,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

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Nanomedicine-enhanced immunogenic cell death (ICD) has attracted considerable attention for its great potential in cancer treatment. Even though polyethylene glycol (PEG) is widely recognized as the gold standard for surface modification of nanomedicines, some shortcomings associated with this PEGylation, such as hindered cell endocytosis and accelerated blood clearance phenomenon, have been revealed in recent years. Notably, polysarcosine (PSar) as a highly biocompatible polymer can be finely synthesized by mild ring-opening polymerization (ROP) of sarcosine N-carboxyanhydrides (Sar-NCAs) and exhibit great potential as an alternative to PEG. In this article, PSar-b-polycamptothecin block copolymers are synthesized by sequential ROP of camptothecin-based NCAs (CPT-NCAs) and Sar-NCAs. Then, the detailed and systematic comparison between PEGylation and PSarylation against the 4T1 tumor model indicates that PSar decoration can facilitate the cell endocytosis, greatly enhancing the ICD effects and antitumor efficacy. Therefore, it is believed that this well-developed PSarylation technique will achieve effective and precise cancer treatment in the near future.

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Section: Materials and Experimental Proceduresmentioning

confidence: 99%

Section: Materials and Experimental Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polysarcosine as PEG Alternative for Enhanced Camptothecin-Induced Cancer Immunogenic Cell Death

Yao,

Sun,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

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“…In general, various strategies have been proposed in designing light-stimulated drug release systems for tumor therapy: (1) absorption of light dissociating the prodrug into its active form; (2) absorption of light by a photosensitive molecule, which triggers a physical change that releases the encapsulated drug [67,68]. The former commonly involves functionalizing the chemotherapeutic drug to obtain a prodrug with reduced cytotoxicity.…”

Section: Light-responsive Nanocarriersmentioning

confidence: 99%

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Liu,

He,

Liu

2024

Preprint

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With the breakthroughs and innovative developments in nanotechnology, research on the application of nanomedicine in cancer therapy has so far seen tremendous expansion and success. Intelligent stimulus-responsive nanocarriers are an emerging field of research and have great interest in cancer therapy owing to the fascinating properties such as excellent targeting function, high drug loading capacity, and targeted on-demand release properties. Responsive nanomaterials can be designed and constructed according to the dosing context and therapeutic needs, at the same time, activated by internal bio-stimuli (pH, redox, and enzymes) and/or external stimuli (ultrasound, light, temperature, and magnetic), respectively. What’s more, smart nanocarriers are also utilized for the precise and controllable release of antitumor drugs from cancer tissues and cells to achieve efficient diagnosis and treatment of tumors. Deeply investigated, responsive nanocarriers have attracted considerable attention due to their ability to release precisely at tumor-specific sites. Herein, we review the recent advances of novel stimuli-responsive nanocarriers in the field of cancer therapy. Finally, the challenges and application prospects of smart nanocarriers are further elaborately discussed.

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Facile Preparation of Polysarcosine‐Tethered Inorganic Nanospheres by Using Unimolecular Polypept(o)ides as Template

Yao,

Hao,

Wang

et al. 2024

Small Methods

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Polymer‐inorganic nanocomposites that integrate the advantages of both polymers and inorganic nanoparticles (NPs) are broadly exploited for versatile applications. Especially, emerging polymer‐templated preparation of inorganic NPs has drawn extensive attention, which is ascribed to simplified synthesis and feasible tunability. However, how to precisely fabricate biocompatible polymer‐inorganic NPs remains unsolved. In this article, by mild ring opening polymerization (ROP) of β‐benzyl L‐aspartate N‐carboxyanhydrides (BLA‐NCAs) and sarcosine N‐carboxyanhydrides (Sar‐NCAs) and subsequent debenzylation, a series of poly(amino acid)‐based unimolecular micelles (PAMAM‐g‐(PLA‐b‐PSar)) are facilely synthesized. Afterward, by utilization of these star‐like polymers as template, the controllable preparation of various PSar‐tethered inorganic NPs is investigated and characterized meticulously. This general strategy for the preparation of PSar‐tethered inorganic NPs can bring a great chance for future fabrication of biomedical nanoplatforms.

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Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy

Cited by 6 publications

References 44 publications

Polysarcosine as PEG Alternative for Enhanced Camptothecin-Induced Cancer Immunogenic Cell Death

Polysarcosine as PEG Alternative for Enhanced Camptothecin-Induced Cancer Immunogenic Cell Death

Shoot the Arrow at the Target: Innovative Stimulus-Responsive Smart Nanocarriers for Cancer Therapy

Facile Preparation of Polysarcosine‐Tethered Inorganic Nanospheres by Using Unimolecular Polypept(o)ides as Template

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