Self-assembly of fluorinated gradient copolymer in three-dimensional co-flow focusing microfluidic

Zhu, Cheng-Zhi; Yao, Rongyi; Chen, Yanjun; Feng, Mengran; Ma, Shuai; Zhang, Chaocan

doi:10.1016/j.jcis.2018.04.076

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…Specifically, the more hydrophobic gradient copolymer was self-assembled in well-defined vesicles [ 122 ]. In another example, Zhang’s group synthesized a gradient copolymer of acrylic acid and 2,2,2-Trifluoroethyl methacrylate P(AA-grad-TFEMA) via RAFT polymerization [ 123 ]. The fluorinated gradient copolymers were self-assembled in a three-dimensional co-flow focusing microfluidic device (3D CFMD), obtaining polymersomes depending on the copolymer concentration and capillary dimensions.…”

Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…Fast, 3D hydrodynamic focusing mixers are critical for many time-resolved studies of structural biology (Wang et al, 2014;Plumridge et al, 2018;, self-assembly of nano-structures (Othman et al, 2015;Zhu et al, 2018), and drug delivery (Vladisavljevic ´et al, 2014;Borro et al, 2019). The 3D flow features of these devices are well suited for line-of-sight integrating techniques which cannot discriminate signal from slow-moving (e.g.…”

Section: Introductionmentioning

confidence: 99%

Millisecond timescale reactions observed via X-ray spectroscopy in a 3D microfabricated fused silica mixer

Huyke¹,

Ramachandran²,

Ramirez-Neri³

et al. 2021

J Synchrotron Radiat

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Determination of electronic structures during chemical reactions remains challenging in studies which involve reactions in the millisecond timescale, toxic chemicals, and/or anaerobic conditions. In this study, a three-dimensionally (3D) microfabricated microfluidic mixer platform that is compatible with time-resolved X-ray absorption and emission spectroscopy (XAS and XES, respectively) is presented. This platform, to initiate reactions and study their progression, mixes a high flow rate (0.50–1.5 ml min−1) sheath stream with a low-flow-rate (5–90 µl min−1) sample stream within a monolithic fused silica chip. The chip geometry enables hydrodynamic focusing of the sample stream in 3D and sample widths as small as 5 µm. The chip is also connected to a polyimide capillary downstream to enable sample stream deceleration, expansion, and X-ray detection. In this capillary, sample widths of 50 µm are demonstrated. Further, convection–diffusion-reaction models of the mixer are presented. The models are experimentally validated using confocal epifluorescence microscopy and XAS/XES measurements of a ferricyanide and ascorbic acid reaction. The models additionally enable prediction of the residence time and residence time uncertainty of reactive species as well as mixing times. Residence times (from initiation of mixing to the point of X-ray detection) during sample stream expansion as small as 2.1 ± 0.3 ms are also demonstrated. Importantly, an exploration of the mixer operational space reveals a theoretical minimum mixing time of 0.91 ms. The proposed platform is applicable to the determination of the electronic structure of conventionally inaccessible reaction intermediates.

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“…In other words, it is possible to achieve a series of preparation and processing that are difficult to complete with conventional methods, including higher particle size uniformity and precise control of the structural assembly. Fluids manipulated by microfluidic technology in these narrow channels have many unique properties, one of the most important is laminar flow [102,103]. In general, flows of common liquids in typical microfluidic channels (<100 µm) are characterized by the laminar state.…”

Section: Microfluidic Methodsmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

234

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Self-assembly of fluorinated gradient copolymer in three-dimensional co-flow focusing microfluidic

Cited by 11 publications

References 38 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Millisecond timescale reactions observed via X-ray spectroscopy in a 3D microfabricated fused silica mixer

Advances in Chitosan-Based Nanoparticles for Drug Delivery

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