Self-Assembly of Copolymer Micelles: Higher-Level Assembly for Constructing Hierarchical Structure

Lu, Yannan; Lin, Jiaping; Wang, Liquan; Zhang, Liangshun; Cai, Chunhua

doi:10.1021/acs.chemrev.9b00774

Cited by 165 publications

(149 citation statements)

References 178 publications

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“…Self-assembly of ionic synthetic co-polymer micelles into higher-level architectures is usually driven by electrostatic interactions. 49 To that end, electrostatic repulsion between charged coronas must be overcome and variations in the pH or addition of counterions. Interestingly, in the diblock co-recombinamers of the present study, the presence of charged residues seemed to be the driving force that triggered the selfassembly into higher-order architectures.…”

Section: Self-assembly Into Nanoparticles and Supramicellar Structuresmentioning

confidence: 99%

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

et al. 2020

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Intrinsically disordered protein polymers (IDPPs) have attracted a lot of attention in the development of bioengineered devices and use as molecular biology study models due to their biomechanical properties and stimuli-responsiveness. The present work aims to understand the effect of charge distribution on self-assembly of IDPPs. To that end, a library of recombinant IDPPs based on an amphiphilic diblock design with different charge distributions were bioproduced and their supramolecular assembly characterized on the nano-, meso-and microscale. Although phase transition was driven by the collapse of hydrophobic moieties, hydrophilic block composition strongly affected hierarchical assembly and, therefore, enabled the production of new molecular

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Section: Self-assembly Into Nanoparticles and Supramicellar Structuresmentioning

confidence: 99%

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

et al. 2020

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“…For instance, most of anticancer drugs are hydrophobic in nature, and therefore, to produce selfassembled nanostructures with better therapeutic and formulation aspects, hydrophilic molecules or polymers are usually attached to them via a degradable linker to induce amphiphilicity and self-assembly ( Figure 6) [60]. Self-assembly widely occurs in nature and has been borrowed by science to formulate self-assembled nano/micro-drug delivery systems with better therapeutic outcomes than original drug molecules [62].…”

Section: Self-assembly Of Covalent Conjugated Drugsmentioning

confidence: 99%

Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

Fasiku¹,

Amuhaya²,

Kingo³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Advancement in chemistry holds a great promise in improving drug encapsulation that leads to superior drug delivery efficiency and the therapeutic efficacy of nano/micro-delivery systems. Drugs are being designed to specifically access the infection sites via covalent conjugation to nano/micro-delivery systems. This chapter focuses on techniques for achieving covalent encapsulation of drugs in nano/micro-delivery systems, how conjugation is applied to selectively influence pharmacokinetic profile, intracellular, and extracellular uptake, specific targeting to disease sites, binding to specific receptors, and controlled/sustained release. In addition, the effect of conjugation on drug efficacy and biosafety of the micro/ nanoparticulate drug delivery systems are discussed.

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“…Precise tailoring of the molecular/supramolecular structure that leads to desirable molecular size, uniformity, topology, composition, and functionality is the core of macromolecular engineering [ 2 ]. The available tools for tailoring of the molecular architectures are controlled/living polymerization methods [ 3 ], click chemistry [ 4 ], supramolecular polymerization [ 5 , 6 ], self-assembly [ 7 , 8 ], among others.…”

Section: Introductionmentioning

confidence: 99%

Macromolecular Engineering by Applying Concurrent Reactions with ATRP

2020

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Modern polymeric material design often involves precise tailoring of molecular/supramolecular structures which is also called macromolecular engineering. The available tools for molecular structure tailoring are controlled/living polymerization methods, click chemistry, supramolecular polymerization, self-assembly, among others. When polymeric materials with complex molecular architectures are targeted, it usually takes several steps of reactions to obtain the aimed product. Concurrent polymerization methods, i.e., two or more reaction mechanisms, steps, or procedures take place simultaneously instead of sequentially, can significantly reduce the complexity of the reaction procedure or provide special molecular architectures that would be otherwise very difficult to synthesize. Atom transfer radical polymerization, ATRP, has been widely applied in concurrent polymerization reactions and resulted in improved efficiency in macromolecular engineering. This perspective summarizes reported studies employing concurrent polymerization methods with ATRP as one of the reaction components and highlights future research directions in this area.

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Self-Assembly of Copolymer Micelles: Higher-Level Assembly for Constructing Hierarchical Structure

Cited by 165 publications

References 178 publications

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

Charge Density as a Molecular Modulator of Nanostructuration in Intrinsically Disordered Protein Polymers

Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

Macromolecular Engineering by Applying Concurrent Reactions with ATRP

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