Self-assembly of concentric microrings of tubule and platy nanoclays for cell patterning and capturing

Kryuchkova, Marina; Batasheva, Svetlana; Naumenko, Ekaterina; Rozhina, Elvira; Akhatova, Farida; Panchal, Abhishek; Lvov, Yuri; Fakhrullin, Rawil

doi:10.1016/j.clay.2020.105707

Cited by 15 publications

(12 citation statements)

References 71 publications

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“…Halloysite nanotubes are a perspective material for obtaining complex nano-featured coati ugh evaporation-induced nanotube self-assembly process [39][40][41]. Previously, prist otubes [42] or nanotubes stabilized by anionic polyelectrolyte PSS [43,44] were used for mak entric ring structures. In this work, the possibility of using DNA modified halloysite nanotu Halloysite nanotubes are a perspective material for obtaining complex nano-featured coatings through evaporation-induced nanotube self-assembly process [39][40][41].…”

Section: Samplementioning

confidence: 99%

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Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

et al. 2020

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Complexation of biopolymers with halloysite nanotubes (HNTs) can greatly affect their applicability as materials building blocks. Here we have performed a systematic investigation of fabrication of halloysite nanotubes complexes with nucleotides and genomic DNA. The binding of DNA and various nucleotide species (polyAU, UMP Na2, ADP Na3, dATP Na, AMP, uridine, ATP Mg) by halloysite nanotubes was tested using UV-spectroscopy. The study revealed that binding of different nucleotides to the nanoclay varied but was low both in the presence and absence of MgCl2, while MgCl2 facilitated significantly the binding of longer molecules such as DNA and polyAU. Modification of the nanotubes with DNA and nucleotide species was further confirmed by measurements of ζ-potentials. DNA-Mg-modified nanotubes were characterized using transmission electron (TEM), atomic force (AFM) and hyperspectral microscopies. Thermogravimetric analysis corroborated the sorption of DNA by the nanotubes, and the presence of DNA on the nanotube surface was indicated by changes in the surface adhesion force measured by AFM. DNA bound by halloysite in the presence of MgCl2 could be partially released after addition of phosphate buffered saline. DNA binding and release from halloysite nanotubes was tested in the range of MgCl2 concentrations (10–100 mM). Even low MgCl2 concentrations significantly increased DNA sorption to halloysite, and the binding was leveled off at about 60 mM. DNA-Mg-modified halloysite nanotubes were used for obtaining a regular pattern on a glass surface by evaporation induced self-assembly process. The obtained spiral-like pattern was highly stable and resisted dissolution after water addition. Our results encompassing modification of non-toxic clay nanotubes with a natural polyanion DNA will find applications for construction of gene delivery vehicles and for halloysite self-assembly on various surfaces (such as skin or hair).

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Section: Samplementioning

confidence: 99%

“…Previously, pristine nanotubes [42] or nanotubes stabilized by anionic polyelectrolyte PSS [43,44] were used for making concentric ring structures. In this work, the possibility of using DNA modified halloysite nanotubes for complex ring pattern formation was tested.…”

Section: Samplementioning

confidence: 99%

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

et al. 2020

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“…Concentric ring patterns obtained from DNA-modified clay nanotubes using the so called “coffee ring effect” turned out to be very durable and washing-resistant, while the structures made from the nanotubes stabilized with synthetic polyelectrolytes were easily broken and washed away with water [ 84 ]. These washing-resistant complex patterns can be used for formation of nanostructured tissue scaffolds, cell capturing or in filtering devices [ 86 ].…”

Section: Cytocompatible and Antibiofouling Dna Coatingsmentioning

confidence: 99%

Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores

Batasheva

Fakhrullin

2021

IJMS

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Biomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polyelectrolyte nature, stability, thermo-responsivity and charge transfer ability that are rather independent of its sequence, have recently become highly appreciated in material science and biomedicine. Whereas the latest achievements in structural DNA nanotechnology associated with DNA sequence recognition and Watson–Crick base pairing between complementary nucleotides are regularly reviewed, the recent uses of DNA as a raw material in biomedicine have not been summarized. This review paper describes the main biomedical applications of DNA that do not involve any synthesis or extraction of oligo- or polynucleotides with specified sequences. These sequence-independent applications currently include some types of drug delivery systems, biocompatible coatings, fire retardant and antimicrobial coatings and biosensors. The reinforcement of DNA properties by DNA complexation with nanoparticles is also described as a field of further research.

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“…Such oriented self-assembled coatings of HNTs on glass 155,156 or polylactic acid (PLA) 157 were also shown to passively affect the orientation of mesenchymal stem cells and to promote their differentiation. Cell contact guidance is enhanced by the self-assembled HNTs substrate which mimics both micro-and nanoscopic features of the biological tissue at the critical dimensions.…”

Section: Bioscaffolds and Tissue Engineeringmentioning

confidence: 99%

Halloysite nanotubes – the nano-bio interface

Setter

Segal

2020

Nanoscale

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Self-assembly of concentric microrings of tubule and platy nanoclays for cell patterning and capturing

Cited by 15 publications

References 71 publications

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores

Halloysite nanotubes – the nano-bio interface

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