Self‐Assembly of Complex DNA Tessellations by Using Low‐Symmetry Multi‐arm DNA Tiles

Zhang, Fei; Jiang, Shuoxing; Li, Wei; Hunt, Ashley; Liu, Yan; Yan, Hao

doi:10.1002/anie.201601944

Cited by 35 publications

(37 citation statements)

References 27 publications

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“…b,c) AFM images for the one pot annealing product and after the second step of the hierarchical folding strategy. [44] Adapted from Ref. [44] with permission from Wiley-VCH Verlag GmbH &C o. KGaA, Weinheim, Copyright 2016. imagesoft he self-assembledp orousn etwork on am ica surface, formed by the two tiles upon annealing at 53 8C.…”

Section: Porous Network Through Self-assembly Of Dna Macromoleculesmentioning

confidence: 99%

“…[44] Adapted from Ref. [44] with permission from Wiley-VCH Verlag GmbH &C o. KGaA, Weinheim, Copyright 2016. imagesoft he self-assembledp orousn etwork on am ica surface, formed by the two tiles upon annealing at 53 8C. [45] Adapted form Ref.…”

Section: Porous Network Through Self-assembly Of Dna Macromoleculesmentioning

confidence: 99%

“…Thee forces often lead to fragmentationo ft he fragile array. [41,44] In this case, single DNA tiles are usually obtained in solution and incubated with the mica support at as pecific temperature, which will trigger the network formation. [41] Furthermore, the interactions with the solid support promote the formation of extended 2D networks from more flexible tiles, which would not be possible to be obtained in solution.…”

Section: Role Of the Solid Supportmentioning

confidence: 99%

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Patterning Porous Networks through Self‐Assembly of Programmed Biomacromolecules

Carloni

Bezzu

Bonifazi

2019

Chemistry A European J

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Two‐dimensional (2D) porous networks are of great interest for the fabrication of complex organized functional materials for potential applications in nanotechnologies and nanoelectronics. This review aims at providing an overview of bottom‐up approaches towards the engineering of 2D porous networks by using biomacromolecules, with a particular focus on nucleic acids and proteins. The first part illustrates how the advancements in DNA nanotechnology allowed for the attainment of complex ordered porous two‐dimensional DNA nanostructures, thanks to a biomimetic approach based on DNA molecules self‐assembly through specific hydrogen‐bond base pairing. The second part focuses the attention on how polypeptides and proteins structural properties could be used to engineer organized networks templating the formation of multifunctional materials. The structural organization of all examples is discussed as revealed by scanning probe microscopy or transmission electron microscopy imaging techniques.

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Section: Porous Network Through Self-assembly Of Dna Macromoleculesmentioning

confidence: 99%

Section: Porous Network Through Self-assembly Of Dna Macromoleculesmentioning

confidence: 99%

Section: Role Of the Solid Supportmentioning

confidence: 99%

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Patterning Porous Networks through Self‐Assembly of Programmed Biomacromolecules

Carloni

Bezzu

Bonifazi

2019

Chemistry A European J

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“…The angle between sticky patches, 120 • , is equal to the internal angle of the hexagon, and so the symmetry of the particle is clearly reflected in the symmetry of the assembly. Three-fold-coordinated DNA particles can also self-assemble into a network equivalent to the 4.8.8 tiling [4,5] (meaning that a square and two octagons encircle each vertex). The model picture in Fig.…”

Section: Introductionmentioning

confidence: 99%

“…The angles 90 • and 135 • are equal to the internal angles of the square and the octagon, making clear the connection between the particle and the assembly. Notably, the sticky patches of the particle must be chemically specific, in the sense that only two types of complementary interaction are possible [5,6]. In the absence of chemical specificity, if all particles stick to all other particles, then there exist too many competing structures to allow self-assembly of the 4.8.8 tiling.…”

Section: Introductionmentioning

confidence: 99%

Irregular model DNA particles self-assemble into a regular structure

2017

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DNA nanoparticles with three-fold coordination have been observed to self-assemble in experiment into a network equivalent to the hexagonal (6.6.6) tiling, and a network equivalent to the 4.8.8 Archimedean tiling. Both networks are built from a single type of vertex. Here we use analytic theory and equilibrium and dynamic simulation to show that a model particle, whose rotational properties lie between those those of the vertices of the 6.6.6 and 4.8.8 networks, can self-assemble into a network built from three types of vertex. Important in forming this network is the ability of the particle to rotate when bound, thereby allowing the formation of more than one type of binding motif. The network in question is equivalent to a false tiling, a periodic structure built from irregular polygons, and possesses 40 particles in its unit cell. The emergence of this complex structure, whose symmetry properties are not obviously related to those of its constituent particles, highlights the potential for creating new structures from simple variants of existing nanoparticles.

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Engineering Lipid Membranes with Programmable DNA Nanostructures

et al. 2019

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Lipid and DNA are abundant biomolecules with critical functions in cells. The water-insoluble, amphipathic lipid molecules are best known for their roles in energy storage (e.g. as triglyceride), signaling (e.g. as sphingolipid), and compartmentalization (e.g. by forming membrane-enclosed bodies). The soluble, highly negatively charged DNA, which stores cells' genetic information, has proven to be an excellent material for constructing programmable nanostructures in vitro thanks to its self-assembling capabilities. These two seemingly distant molecules make contact within cell nuclei, often via lipidated proteins, with proposed functions of modulating chromatin structures. Carefully formulated lipid/DNA complexes are promising reagents for gene therapy. The past few years saw an emerging research field of interfacing DNA nanostructures with lipid membranes, with an overarching goal of generating DNA/lipid hybrid materials that possess novel and controllable structure, dynamics, and function. An arsenal of DNA-based tools has been created to coat, mold, deform, and penetrate lipid bilayers, affording us the ability to manipulate membranes with nanoscopic precision. These membrane engineering methods not only enable quantitative biophysical studies, but also open new opportunities in synthetic biology (e.g. artificial cells) and therapeutics (e.g. drug delivery).

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Self‐Assembly of Complex DNA Tessellations by Using Low‐Symmetry Multi‐arm DNA Tiles

Cited by 35 publications

References 27 publications

Patterning Porous Networks through Self‐Assembly of Programmed Biomacromolecules

Patterning Porous Networks through Self‐Assembly of Programmed Biomacromolecules

Irregular model DNA particles self-assemble into a regular structure

Engineering Lipid Membranes with Programmable DNA Nanostructures

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