2001
DOI: 10.1126/science.1063187
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Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers

Abstract: We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment … Show more

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Cited by 3,480 publications
(3,081 citation statements)
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References 40 publications
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“…42,44,45 Comparison of our structures 42 showed a high degree of similarity with those observed in experimental structures. 2,12 Moreover, the simulations that were conducted by the Schatz group using atomistic and coarsegrained models 52−54 with explicit solvents produce similar structures as those observed by our simulations. This evidence validates our use of implicit solvent model without biasing the results of the selfassembling behavior.…”
Section: Methodssupporting
confidence: 78%
See 1 more Smart Citation
“…42,44,45 Comparison of our structures 42 showed a high degree of similarity with those observed in experimental structures. 2,12 Moreover, the simulations that were conducted by the Schatz group using atomistic and coarsegrained models 52−54 with explicit solvents produce similar structures as those observed by our simulations. This evidence validates our use of implicit solvent model without biasing the results of the selfassembling behavior.…”
Section: Methodssupporting
confidence: 78%
“…24,26 Individual fibrillar nanostructures are characterized by cylindrical nanofibers that exhibit β-sheet elements on the surface with a hydrophobic core. 2,11 Early design principles of PA molecules have primarily emphasized structural modifications to improve biocompatibility or to minimize immunogenic properties; 11,27 however, with the aims to use PA self-assembled nanostructures as a synthetic hydrogel scaffold that mimics extracellular matrix, consideration is also placed on the relationship between structural characteristics and mechanical behavior. For example, modifying the mechanical rigidity of hydrogels serving as extracellular matrix results in different cell adhesion and cell differentiation behaviors.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies report promising results of this strategy. For example, a peptide amphiphile (chemical compound possessing both hydrophilic and hydrophobic properties) nanofibre network could be mineralised with hydroxyapatite to recreate the nanoscale structure of bone [35]. These amphiphile nanofibres have been designed to mimic the collagen structure-building protein-like structural motifs that incorporate sequences of biological interest [36].…”
Section: Self-assemblymentioning
confidence: 99%
“…PA nanostructures have the potential, for example, to be used to template the bone mineral hydroxyapatite, which is the body's primary storage depot for calcium and phosphorus in bones 59, 60. A further avenue of interest is the incorporation of other metals, such as titanium, with mineralizing PAs to form hybrid bone implants.…”
Section: Applications Of Self‐assembled Pas and Lipopeptidesmentioning
confidence: 99%