Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer

Chen, Liqiong; Zhang, Liming; Chen, Jianjun; Yang, Jian; Li, Rongxian

doi:10.1007/s11434-010-3246-9

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…Such a behavior was previously reported with poly( N , N ‐diethylacrylamide) star polymers keeping Nile red inside the aggregates above their LCST . In order to improve the VK1 diffusion from the hydrophobic clusters to the aqueous phase, the release experiments were carried out in presence of 10 v:v% of ethanol as already reported for release experiments of indomethacin from poly(2‐ethyl‐2‐oxazoline) . In such conditions, no VK1 release is observed below T CP during 4 h. Indeed, as already reported, poly(oxazoline) chains form intermolecular hydrogen bonds thus increasing the corona cohesion and restricting the drug diffusion .…”

Section: Resultssupporting

confidence: 52%

Synthesis of Dual‐Sensitive Core Cross‐Linked Mixed Micelles through Thiol–Ene Addition and Subsequent Drug Release Behavior

Hespel

Morandi

Lecamp

et al. 2017

Macro Chemistry & Physics

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Herein the synthesis of core cross‐linked (CCL) mixed micelles through a UV‐promoted thiol–ene addition onto lipid core unsaturations and the subsequent release of an encapsulated drug depending on the external conditions (pH/temperature) are reported. The thiol–ene addition proceeds even in the absence of a photoinitiator to reach a complete conversion in a few minutes in bulk. The cross‐linking reaction is applied in aqueous media onto lipid‐b‐poly(acrylic acid) (lipid‐b‐PAA) only and then a mixture of pH‐sensitive lipid‐b‐PAA and thermo‐sensitive lipid‐block‐poly(2‐isopropyl‐2‐oxazoline) copolymers. Structurally CCL micelles, preserved in any conditions, with a stimuli‐sensitive corona whose swelling depends on the external pH or/and temperature, are successfully prepared. The release of vitamin K1 (VK1) is then investigated from all the previous systems and demonstrates a strong dependency to the external conditions. Indeed, the dual‐sensitive CCL micelles release VK1 only when two triggers (pH 10 and T = 38 °C) are simultaneously activated.

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Section: Resultssupporting

confidence: 52%

Synthesis of Dual‐Sensitive Core Cross‐Linked Mixed Micelles through Thiol–Ene Addition and Subsequent Drug Release Behavior

Hespel

Morandi

Lecamp

et al. 2017

Macro Chemistry & Physics

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“…The indispensable role that carbohydrates and their derivatives play in some important biological processes including bacteria infection, signal transduction, and immune response have been studied for decades. − The recent tremendous developments of such research in glycobiology largely depend on the sufficient usage of various chemical tools, especially carbohydrate chemistry. , Carbohydrate chemistry enables not only precise reproduction of natural carbohydrate structures, but also design and preparation of unnatural carbohydrate derivatives. The latter helps mimic a lot of biological structures aimed at revealing their functions, as well as creating biomimetic materials. − Among these materials, glycopolymer normally bearing multiple numbers of saccharides as side chains is one of the most important building blocks. − …”

Section: Introductionmentioning

confidence: 99%

Role of Protecting Groups in Synthesis and Self-Assembly of Glycopolymers

et al. 2017

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Protection and deprotection are basic procedures in oligosaccharide synthesis. By taking advantage of the processes of attaching and removing the protecting groups, preparation of oligosaccharides with complex structures can be achieved with relatively high yields. However, the role of protecting groups in solution properties and self-assembly of synthetic glycopolymers has been overlooked in the literature. In this paper, we focused on such effects for well-designed copolymers in which different numbers of benzyl (Bn) groups are installed regioselectively in saccharide rings. Thus, three block copolymers P1, P2, and P3 composed of a common block of PNIPAm and a glycopolymer block with trisaccharide triMan side chains differing in the respective number of Bn (0, 2, and 6) were prepared. The solutions of these block copolymers in water were investigated by dynamic and static light scatting and VT-H NMR. We found that all of the three copolymers P1, P2, and P3 formed association at room temperature. Particularly, P1 associated loosely due to carbohydrate-carbohydrate interaction (CCI) while P3 formed tight aggregates due to hydrophobic interactions between Bn, and P2 behaved between those of P1 and P3. Moreover, upon heating, phase transition of PNIPAm block took place leading to micelle formation. Hydrodynamic radius of P1 and P2 increased significantly as expected, while P3 did not follow this trend, because during heating, collapse and accumulation of the PNIPAm chains would occur within the tight aggregates mainly, so it leads to a little change of the size.

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“…42 To the best of our knowledge, up to now only one additional publication exists describing the preparation of thermo-responsive glyco-poly(2-oxazoline)s based on peracetylated maltoheptanose end capped poly(2-oxazoline)s (POx). 43 In this contribution, we report the systematic investigation of the LCST behavior of a series of glycopolymers derived from a precursor copolymer with a constant [M]/[I] ratio and varying ratio of 2-ethyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline. The glycopolymers were prepared by polymer post-modification exploiting the photoaddition of thiols onto pendant alkene functionalities.…”

Section: Introductionmentioning

confidence: 99%