Self‐Assembly and Antitumor Activity of a Polyoxovanadate‐Based Coordination Nanocage

Zheng, Yan; Gan, Hongmei; Zhao, Yao; Li, Wanling; Wu, Yuchen; Yan, Xuechun; Wang, Yifan; Li, Jinhua; Li, Juan; Wang, Xinlong

doi:10.1002/chem.201903333

Cited by 22 publications

(5 citation statements)

References 39 publications

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“…The researchers used human normal bronchial epithelial cell line (BEAS-2B) to study the cytotoxicity of VMOP-31. The obtained IC 50 values are markedly lower than those in SMMC-7721, MCF-7, and A549 cell lines, which indicates that VMOP-31 is selectively toxic toward solid tumor cells over normal cells [61]. In addition, peptides can also serve as excellent ligands.…”

Section: Application Of Novel Pom Nanocompositesmentioning

confidence: 90%

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

et al. 2022

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As shown in studies conducted in recent decades, polyoxometalates (POMs), as inorganic metal oxides, have promising biological activities, including antitumor, anti-infectious and anti-Alzheimer's activities, due to their special structures and properties. However, some side effects impede their clinical applications to a certain extent. Compared with unmodified POMs, POM-based inorganic-organic hybrids and POM-based nanocomposite structures show significantly enhanced bioactivity and reduced side effects. In this review, we introduce the biological activities of POMs and their derivatives and highlight the side effects of POMs on normal cells and organisms and their possible mechanisms of action. We then propose a development direction for overcoming their side effects. POMs are expected to constitute a new generation of inorganic metal drugs for the treatment of cancer, infectious diseases, and Alzheimer's disease.

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Section: Application Of Novel Pom Nanocompositesmentioning

confidence: 90%

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

et al. 2022

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“…Similarly, POT and POMos studies together represent the majority (90%), whereas for POVs and PONbs, lower percentages can be found. In fact, more than 120 articles/papers have been published with POMos and polyoxotungstates POTs in antitumor studies [8,[10][11][12][13][80][81][82][83][84][85][86][87][88][89]. POMs in cancer therapy and diagnostics, their modes of action, and future perspectives were reviewed [2,[90][91][92][93].…”

Section: Anticancer Activity Of Polyoxometalatesmentioning

confidence: 99%

The Future Is Bright for Polyoxometalates

Aureliano

2022

BioChem

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Polyoxometalates (POMs) are clusters of units of oxoanions of transition metals, such as Mo, W, V and Nb, that can be formed upon acidification of neutral solutions. Once formed, some POMs have shown to persist in solution, even in the neutral and basic pH range. These inorganic clusters, amenable of a variety of structures, have been studied in environmental, chemical, and industrial fields, having applications in catalysis and macromolecular crystallography, as well as applications in biomedicine, such as cancer, bacterial and viral infections, among others. Herein, we connect recent POMs environmental applications in the decomposition of emergent pollutants with POMs’ biomedical activities and effects against cancer, bacteria, and viruses. With recent insights in POMs being pure, organic/inorganic hybrid materials, POM-based ionic liquid crystals and POM-ILs, and their applications in emergent pollutants degradation, including microplastics, are referred. It is perceived that the majority of the POMs studies against cancer, bacteria, and viruses were performed in the last ten years. POMs’ biological effects include apoptosis, cell cycle arrest, interference with the ions transport system, inhibition of mRNA synthesis, cell morphology changes, formation of reaction oxygen species, inhibition of virus binding to the host cell, and interaction with virus protein cages, among others. We additionally refer to POMs’ interactions with various proteins, including P-type ATPases, aquoporins, cinases, phosphatases, among others. Finally, POMs’ stability and speciation at physiological conditions are addressed.

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“…[ 167 ] Moreover, utilizing the interfacial coordination interactions between the Ag + ion at the surface of Ag NPs and O/N atom of a fluorescent cyano‐carboxylic derivative (noted as CECZA), a two‐photon PTT agent was fabricated through self‐assembly of Ag NPs and CECZA, and the assemblies demonstrated good PTT effect on HeLa cells. [ 168 ] Apart from the works mentioned above, there are others studies on the use of the coordination effect derived from V 3+/4+ , [ 24 , 169 ] Zr 4+ , [ 170 ] Ag + , [ 171 ] Hf 4+ , [ 91 , 92 , 93 , 94 ] Sn 4+ , [ 172 ] Re + , [ 173 ] Ir 3+ , [ 174 ] and Bi 3+[ 175 ] to fabricate various nanoplatforms for cancer theranostic investigation.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Self‐Assembly and Antitumor Activity of a Polyoxovanadate‐Based Coordination Nanocage

Cited by 22 publications

References 39 publications

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer’s disease

The Future Is Bright for Polyoxometalates

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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