Self-Assembling Peptide SCIBIOIII Hydrogel for Three-Dimensional Cell Culture That Promotes Wound Healing in Diabetic Mice

Abstract

An important clinical challenge is improving the healing rate of diabetic chronic wounds, and developing new approaches that can promote chronic wound healing is essential. A new biomaterial that has demonstrated great potential for tissue regeneration and repair is self-assembling peptides (SAPs); however, they have been less studied for the treatment of diabetic wounds. Here, we explored the role of an SAP, SCIBIOIII, with a special nanofibrous structure mimicking the natural extracellular matrix for chronic diabetic wound repair. The results showed that the SCIBIOIII hydrogel in vitro has good biocompatibility and can create a three-dimensional (3D) culture microenvironment for the continuous growth of skin cells in a spherical state. The SCIBIOIII hydrogel in diabetic mice (in vivo) significantly improved wound closure, collagen deposition, and tissue remodeling and enhanced chronic wound angiogenesis. Thus, the SCIBIOIII hydrogel is a promising advanced biomaterial for 3D cell culture and diabetic wound tissue repair.

Self-Assembled Peptide Hydrogels in Regenerative Medicine

“…Lu et al similarly explored using the SAP SCIBIOIII to form a special nanofiber structure mimicking the natural ECM in chronic diabetic wound repair. They showed that the SCIBIOIII hydrogel had good in vitro biocompatibility and could create a 3D culture microenvironment for continuous spherical skin cell growth [ 40 ]. In addition, the SCIBIOIII hydrogel significantly improved wound closure, collagen deposition, and tissue remodeling and enhanced chronic wound angiogenesis in diabetic mice.…”

Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

“…GDF5 plays an important role in the formation and development of bones, joints, and neurons during human growth and development. Furthermore, it has a positive effect on skin healing and recovery [ [37] , [38] , [39] ]. Therefore, GDF5 has extensive application prospects in the medical field, especially in the field of regenerative medicine, such as bone and joint repair and nerve injury repair [ 40 , 41 ].…”