Self-Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering

Hao, Zhuowen; Chen, Tianhong; Wang, Ying; Feng, Qinyu; Chen, Jiayao; Li, Hanke; Wang, Junwu; Wang, Zepu; Zhang, Zheyuan; Chen, Renxin; Shi, Guang; Zou, Zhenwei; Cai, Lin; Zhu, Tonghe; Li, Jingfeng

doi:10.1007/s42765-023-00370-9

Cited by 5 publications

(1 citation statement)

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“…Good biocompatibility and osteogenesis capability of biomaterials are necessary for bone regeneration. 66 Cytoskeleton staining on days 3 and 5 showed a spreading cytoskeleton of BMSCs on the different composite scaffolds in a short-pike shape with no significant difference in cell morphology compared with the control group (Figure 7a). The viability of BMSCs on the different composite scaffolds was verified by CCK-8 (Figure 7b).…”

Section: Characterization Of the Composite Scaffoldsmentioning

confidence: 97%

Methacrylated Carboxymethyl Chitosan Scaffold Containing Icariin-Loaded Short Fibers for Antibacterial, Hemostasis, and Bone Regeneration

Tang,

Wang,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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Bone defects typically result in bone nonunion, delayed or nonhealing, and localized dysfunction, and commonly used clinical treatments (i.e., autologous and allogeneic grafts) have limited results. The multifunctional bone tissue engineering scaffold provides a new treatment for the repair of bone defects. Herein, a three-dimensional porous composite scaffold with stable mechanical support, effective antibacterial and hemostasis properties, and the ability to promote the rapid repair of bone defects was synthesized using methacrylated carboxymethyl chitosan and icariin-loaded poly-L-lactide/gelatin short fibers (M-CMCS-SFs). Icariin-loaded SFs in the M-CMCS scaffold resulted in the sustained release of osteogenic agents, which was beneficial for mechanical reinforcement. Both the porous structure and the use of chitosan facilitate the effective absorption of blood and fluid exudates. Moreover, its superior antibacterial properties could prevent the occurrence of inflammation and infection. When cultured with bone mesenchymal stem cells, the composite scaffold showed a promotion in osteogenic differentiation. Taken together, such a multifunctional composite scaffold showed comprehensive performance in antibacterial, hemostasis, and bone regeneration, thus holding promising potential in the repair of bone defects and related medical treatments.

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Section: Characterization Of the Composite Scaffoldsmentioning

confidence: 97%