Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

Abstract

Wound healing is a long-term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide comprehensive and convenient treatment. The complexity of wounds has led to a lack of adequate wound treatment materials, which must systematically regulate unique wound microenvironments. Hydrogels have significant advantages in wound treatment due to their ability to provide spatiotemporal control over the wound healing process. Self-assembling peptide-based hydrogels are particularly attractive due to their innate biocompatibility and biodegradability along with additional advantages including ligand-receptor recognition, stimulus-responsive self-assembly, and the ability to mimic the extracellular matrix. The ability of peptide-based materials to self-assemble in response to the physiological environment, resulting in functionalized microscopic structures, makes them conducive to wound treatment. This review introduces several self-assembling peptide-based systems with various advantages and emphasizes recent advances in self-assembling peptide-based hydrogels that allow for precise control during different stages of wound healing. Moreover, the development of multifunctional self-assembling peptide-based hydrogels that can regulate and remodel the wound immune microenvironment in wound therapy with spatiotemporal control has also been summarized. Overall, this review sheds light on the future clinical and practical applications of self-assembling peptide-based hydrogels.

Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

“…The intervention efficacy of HA‐Pam‐Mg was a result of the combined effect of Mg 2+ and other biological macromolecules, [ 64 ] apart from the Mg 2+ ‐induced neurite outgrowth effect that we confirmed from our in vitro study, the porous structure formed by hydrogel could also provide structural support for axon growth which is one of the recognized advantages of hydrogel application in tissue engineering. [ 65 ] However, since HA‐Pam‐Mg hydrogel fully degraded within 2 weeks, we could not delineate the specific effect of Mg 2+ contributing to nerve regeneration, remyelination, and functional recovery on week 12.…”

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

“…In addition to HA‐based hydrogels which are mentioned above, peptidic hydrogels have also been explored for their propensity to accelerate wound closure and healing [212,213] . Jarrahy et al.…”

“…In addition to HA-based hydrogels which are mentioned above, peptidic hydrogels have also been explored for their propensity to accelerate wound closure and healing. [212,213] Jarrahy et al synthesised bioactive peptide amphiphile nanofiber gels capable of enhancing the recovery of deep partial thickness burn wounds by stimulating cell proliferation. [214]…”

Self-Assembled Peptide Nanostructures for ECM Biomimicry

“…Readers interested in the details of their various types of design are recommended to read a recent book chapter that provides a comprehensive overview of the topic [24]. Several recent reviews also cover this area [25,26], as well as the use of enzymes to control self-assembly [27], applications for the delivery of drugs and therapeutics [28][29][30][31][32][33], proteins [34,35], and, more generally biomedical uses [36], with a specific focus on antimicrobials [37], cancer [38], and wound healing too [39].…”