Self-assembling peptide-based hydrogels: Fabrication, properties, and applications

Fu, Kun; Wu, Hanguang; Su, Zhiqiang

doi:10.1016/j.biotechadv.2021.107752

Cited by 55 publications

(36 citation statements)

References 117 publications

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“…On the other hand, the artificial synthetic polymeric gel has the merits of adjustable molecular weight or mechanical properties. It has been developed and utilized in many areas, such as biomedicine, bioinspired materials, and flexible wearable devices. , The representative polymers of the synthetic polymeric gels are polyethylene glycol (PEG), polyacrylamide derivatives (polyacrylamide (PAAm), poly( N -isopropylacrylamide) (PNIPAM), poly( N , N -dimethylacrylamide) (PDMAA), poly(2-dimethylaminoethyl methacrylate) (PDMAEMA)), polyacrylate derivatives (poly(hydroxyethyl acrylate) (PHEA), poly(hydroxyethyl methacrylate) (PHEMA)), poly(acrylic acid) (PAAc), polyethylenimine (PEI), poly(vinyl alcohol) (PVA), polyvinylpyrrolidone (PVP), and polypeptide. , It is worth pointing out that, with the development of the diversity of gel network structures, many polymeric gels contain both natural and artificial polymers, such as double network (DN) gel with one natural polymeric network and one synthetic polymeric network. They inherit the advantages of both natural and synthetic polymers and may have more advanced performances.…”

Section: Polymeric Gels and Fluorescencementioning

confidence: 99%

Recent Advances in Applied Fluorescent Polymeric Gels

Dai

2022

ACS Appl. Polym. Mater.

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Fluorescent polymeric gels (FPGs) are soft luminescent materials in which the fluorophore is the source of photoluminescence and the three-dimensional polymeric network is the fundamental matrix; thus, they have features of both fluorescent materials and gels. Furthermore, the tunable space in the gel network allows for control of the optical behaviors of the fluorophores, which are normally sensitive to the microenvironment. Therefore, FPGs can be considered a superior platform for developing functional materials and have stimulated great interest as candidate substances in multiple application areas to date. Herein, an overview of the recent development of FPGs with diverse applications is provided. Fabrication methods are illustrated from the perspective of the relationship between the fluorophore and the polymeric network. Advanced applications of FPGs in various areas including biomedical, environmentally-related, and informationally-related applications and bioinspired materials are comprehensively reviewed. In addition, the current challenges and future development tendencies are also discussed.

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Section: Polymeric Gels and Fluorescencementioning

confidence: 99%

Recent Advances in Applied Fluorescent Polymeric Gels

Dai

2022

ACS Appl. Polym. Mater.

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“…This polymer, as the result of deacetylated chitin, a marine polysaccharide, has a heterogeneous chemical structure composed of N -acetyl-glucosamine and N -glucosamine units. Only second to chitosan hydrogels, peptide hydrogels are composed of macromolecules that confer biocompatibility and degradability which are great for biomedical applications such as wound healing [ 121 ]. Although less common, fibrin and fibrinogen-based hydrogels have been linked to augmented wound healing.…”

Section: No-releasing Hydrogel-based Systemsmentioning

confidence: 99%

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

2022

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Despite the noticeable evolution in wound treatment over the centuries, a functional material that promotes correct and swift wound healing is important, considering the relative weight of chronic wounds in healthcare. Difficult to heal in a fashionable time, chronic wounds are more prone to infections and complications thereof. Nitric oxide (NO) has been explored for wound healing applications due to its appealing properties, which in the wound healing context include vasodilation, angiogenesis promotion, cell proliferation, and antimicrobial activity. NO delivery is facilitated by molecules that release NO when prompted, whose stability is ensured using carriers. Hydrogels, popular materials for wound dressings, have been studied as scaffolds for NO storage and delivery, showing promising results such as enhanced wound healing, controlled and sustained NO release, and bactericidal properties. Systems reported so far regarding NO delivery by hydrogels are reviewed.

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“…Over the last two decades, research on supramolecular hydrogels has grown exponentially because of the revolutionary applications of these materials in biomedical technology. − In addition to more conventional uses such as controlled drug release and wound dressing, hydrogels have found extraordinary applications in tissue engineering with the production of cell adhesion scaffolds, the design of artificial skin, and the 3D bioprinting of prosthetic corneas and vascularized organoids. − Indeed, the production of bioinks from peptide-based hydrogels has opened avenues for designing of organotypic cultures endowed with tunable properties. , From the perspective of basic research, these matrices are equally impressive. The 3D arrangement of the supporting medium influences a variety of cell behaviors such as proliferation, differentiation, and signaling, and hydrogels are able to emulate both the topology and the chemical milieu of the extracellular matrix to provide more realistic mimics for in vivo conditions .…”

Section: Introductionmentioning

confidence: 99%

Nanostructure Formation and Cell Spheroid Morphogenesis of a Peptide Supramolecular Hydrogel

et al. 2022

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Peptide-based hydrogels have attracted much attention due to their extraordinary applications in biomedicine and offer an excellent mimic for the 3D microenvironment of the extracellular matrix. These hydrated matrices comprise fibrous networks held together by a delicate balance of intermolecular forces. Here, we investigate the hydrogelation behavior of a designed decapeptide containing a tetraleucine self-assembling backbone and fibronectin-related tripeptides near both ends of the strand. We have observed that this synthetic peptide can produce hydrogel matrices entrapping >99% wt/vol % water. Ultrastructural analyses combining atomic force microscopy, small-angle neutron scattering, and X-ray diffraction revealed that amyloid-like fibrils form cross-linked networks endowed with remarkable thermal stability, the structure of which is not disrupted up to temperatures >80 °C. We also examined the interaction of peptide hydrogels with either NIH3T3 mouse fibroblasts or HeLa cells and discovered that the matrices sustain cell viability and induce morphogenesis into grape-like cell spheroids. The results presented here show that this decapeptide is a remarkable building block to prepare highly stable scaffolds simultaneously endowed with high water retention capacity and the ability to instruct cell growth into tumor-like spheroids even in noncarcinoma lineages.

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Self-assembling peptide-based hydrogels: Fabrication, properties, and applications

Cited by 55 publications

References 117 publications

Recent Advances in Applied Fluorescent Polymeric Gels

Recent Advances in Applied Fluorescent Polymeric Gels

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

Nanostructure Formation and Cell Spheroid Morphogenesis of a Peptide Supramolecular Hydrogel

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