Self-assembling of graphene oxide on carbon quantum dot loaded liposomes

Hashemi, Mohadeseh; Mohammadi, Javad; Omidi, Meisam; Muralidharan, Bharadwaj; Milner, Thomas E.; Yadegari, Amir; Ahmadvand, Davoud; Shalbaf, Mohammad

doi:10.1016/j.msec.2019.109860

Cited by 10 publications

(4 citation statements)

References 63 publications

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“…Mohammadi and co‐workers simultaneously loaded CQDs and Dox into a reduced graphene oxide (rGO)‐containing thermosensitive liposome. [ 373 ] Such a hybridized liposome carrier system is capable of having a synergistic effect resulting from PTT and chemotherapy as well as an online monitoring function for the intracellular release of the loaded drug. Chu and co‐workers created a multimodal therapeutic O/I hybrid system.…”

Section: Therapeutic Modalities For Combating Cancer Via O/i Hybridsmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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Since the conceptualization of nanomedicine, numerous nanostructure‐mediated drug formulations have progressed into clinical trials for treating cancer. However, recent clinical trial results indicate such kind of drug formulations has a limited improvement on the antitumor efficacy. This is due to the biological barriers associated with those formulations, for example, circulation stability, extravasation efficiency in tumor, tumor penetration ability, and developed multi‐drug resistance. When employing for nanomedicine formulations, pristine organic‐based and inorganic‐based nanostructures have their own limitations. Accordingly, organic/inorganic (O/I) hybrids have been developed to integrate the merits of both, and to minimize their intrinsic drawbacks. In this context, the recent development in O/I hybrids resulting from a self‐assembly strategy will be introduced. Through such a strategy, organic and inorganic building blocks can be self‐assembled via either chemical covalent bonds or physical interactions. Based on the self‐assemble procedure, the hybridization of four organic building blocks including liposomes, micelles, dendrimers, and polymeric nanocapsules with five functional inorganic nanoparticles comprising gold nanostructures, magnetic nanoparticles, carbon‐based materials, quantum dots, and silica nanoparticles will be highlighted. The recent progress of these O/I hybrids in advanced modalities for combating cancer, such as, therapeutic agent delivery, photothermal therapy, photodynamic therapy, and immunotherapy will be systematically reviewed.

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Section: Therapeutic Modalities For Combating Cancer Via O/i Hybridsmentioning

confidence: 99%

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Yang

Lin

Chen

et al. 2021

Macromolecular Bioscience

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“…33 So far, a large variety of approaches have been developed to synthesize CDs with different compositions and chemical structures, which are mainly divided into top-down methods based on cutting different carbon materials (e.g., carbon fiber, graphene oxide (GO), fullerenes and graphite electrodes) and bottom-up methods that are generally involved in the organic synthesis of small molecules, self-assembly of polycyclic aromatic hydrocarbons and carbonization of carbohydrates. [34][35][36][37] Many characterization techniques have been employed to evaluate the chemical structure of CDs, such as ultra-violet visible (UV-vis) spectroscopy, 38,39,52 Fourier transform infra-red (FTIR) spectroscopy, 40,53 X-ray diffraction (XRD), 41,47 X-ray photoelectron spectroscopy (XPS), 42,53 nuclear magnetic resonance (NMR) 43,54 and Raman spectroscopy 44,51 (Fig. 1a-i).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic studies of the optical properties of carbon dots: recent advances and future prospects

Zhao

Song

Yang

2020

Mater. Chem. Front.

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“…The GO spectrum showed the presence of the O–H group at 3368, C=O at 1733, C=C at 1622, and C–O at 1129 cm. –1 18 The noticeable decline in the O–H peak indicates the reduction of GO in the RGO/AuNPs spectrum 19 . By interaction of aptamer chains with RGO/AuNPs, the intensity of O–H peak decreased more due to coverage of RGO/AuNPs surface with aptamer chains.…”

Section: Resultsmentioning

confidence: 99%

An electrochemical aptasensor for detection of prostate‐specific antigen using reduced graphene gold nanocomposite and Cu/carbon quantum dots

Mehdipour

Shayeh

Omidi

et al. 2021

Biotech and App Biochem

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We report a label-free electrochemical aptamer-based biosensor for the detection of human prostate-specific antigen (PSA). The thiolate DNA aptamer against PSA was conjugated to the reduced graphene oxide/Au (RGO-Au) nanocomposite through the self-assembly of Au-S groups. Owing to the large volume to surface ratio, the RGO-Au nanocomposite provides a large surface for aptamer loading. The RGO-Au/aptamer was combined with a Nafion polymer and immobilized on a glassy carbon electrode. The interaction of aptamer with PSA was studied by cyclic voltammetry, square wave voltammetry, and electrochemical impedance spectroscopy. The detection of limit for prepared electrode was obtained about 50 pg/mL at the potential of 0.4 V in potassium hexacyanoferrate [K 4 Fe(CN) 6 ] medium. To decrease the limit of detection (LOD) and applied potential of the prepared nanoprobe Cu/carbon quantum dots (CuCQD) is introduced as a new redox. The results show that this new electrochemical medium provides better conditions for the detection of PSA. LOD of a nanoprobe in CuCQD media was obtained as 40 pg/mL at the potential of −0.2 V. Under optimal conditions, the aptasensor exhibits a linear response to PSA with a LOD as small as 3 pg/mL. The present aptasensor is highly selective and sensitive and shows satisfactory stability and repeatability.

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Self-assembling of graphene oxide on carbon quantum dot loaded liposomes

Cited by 10 publications

References 63 publications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

Spectroscopic studies of the optical properties of carbon dots: recent advances and future prospects

An electrochemical aptasensor for detection of prostate‐specific antigen using reduced graphene gold nanocomposite and Cu/carbon quantum dots

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