Self-assembling of fibers inside an injectable calcium phosphate bone cement: a feasibility study

Filippo, Maria Francesca Di; Giuri, Demetra; Marchiori, Gregorio; Maglio, Melania; Pagani, Stefania; Fini, Milena; Tomasini, Claudia; Panzavolta, Silvia

doi:10.1016/j.mtchem.2022.100991

Cited by 7 publications

(8 citation statements)

References 46 publications

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“…The gelation propensity of gelator 1 was previously reported by our group under several conditions [ 21 , 26 , 27 ] that never allowed us to obtain a hydrogel at neutral pH, needed for biological applications. The dissolution of gelators bearing a free acidic moiety at the C -terminus in water can occur in the presence of NaOH or other bases, usually at a pH of about 10.…”

Section: Resultsmentioning

confidence: 99%

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

et al. 2023

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Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.

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Section: Resultsmentioning

confidence: 99%

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

et al. 2023

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“…[ 12 ] In this step, the formation of polymer chains helped the cohesion between the crosslinking hydrogel fibers and forming cementitious particles. [ 29 ] SEM images of the hydrogel network with and without CMPC particles are shown in Figure 2B,C. They both possess the interconnected porous structure, while the surface of GEL‐CMPC hydrogel is much rougher than the GEL hydrogel due to the attachment of inorganic particles, which are spindle‐shaped with a length ranging from 0.1 to 5.0 μm (Figure 2D).…”

Section: Resultsmentioning

confidence: 99%

A tough injectable self‐setting cement‐based hydrogel for noninvasive bone augmentation

Jin,

Xia,

Hasany

et al. 2023

Interdisciplinary Materials

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Composite hydrogels with excellent properties can open new opportunities to terminate the need for auto/allografts in bone augmentations. However, their clinical application has been limited by their insufficient mechanical strength and lack of osteoinductivity. Here we report a new strategy to design an injectable bioactive double network hydrogel reinforced by inorganic calcium/magnesium phosphate cement (CMPC) hydrates to meet the mechanical performance requirements for bone regeneration. The engineered CMPC hydration endows the composite hydrogel with an appropriate gelation time and temperature for injection, which shows no harm in the defect site. CMPC hydrates could also provide a lower swelling ratio and higher biodegradation rate fitting the in vivo bone regeneration needs. In vitro and in vivo experiments prove that the ions released from inorganic particles endow biocompatibility, cell migration, adhesion, differentiation, and significantly higher bone regeneration capacity. Taken together, the simple addition of CMPC particles imparts in‐demand features that bring us closer to the clinical utilization of hydrogel‐based materials for bone regeneration.

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“…For this aim, we prepared some gels using Boc-L-DOPA(Bn) 2 -OH [ 45 , 46 ], a gelator widely used in our research lab ( Figure 2 ) [ 47 ]. This gelator can form a variety of noncovalent interactions (π-π stackings between the aromatic rings and H-bonds in the carbamate and carboxylic acid portions, as illustrated in Figure S1 ) and demonstrated its robustness forming gels under several conditions and in the presence of different fillers [ 10 , 48 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

Controlled Lactonization of o-Coumaric Esters Mediated by Supramolecular Gels

Cenciarelli

Falini

Giuri

et al. 2023

Gels

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Fragrances are volatile organic compounds widely used in our daily life. Unfortunately, the high volatility required to reach human receptors reduces their persistency in the air. To contrast this effect, several strategies may be used. Among them, we present here the combination of two techniques: the microencapsulation in supramolecular gels and the use of profragrances. We report a study on the controlled lactonization of four esters derived from o-coumaric acid. The ester lactonization spontaneously occurs after exposure to solar light, releasing coumarin and the corresponding alcohol. To determine the rate of fragrance release, we compared the reaction in solution and in a supramolecular gel and we demonstrated that the lactonization reaction always occurs slower in the gel. We also studied the more suitable gel for this aim, by comparing the properties of two supramolecular gels obtained with the gelator Boc-L-DOPA(Bn)2-OH in a 1:1 ethanol/water mixture in different gelator concentration (0.2% and 1% w/v). The gel prepared with 1% w/v gelator concentration is stronger and less transparent than the other and was used for the profragrances encapsulation. In any case, we obtained a significative reduction of lactonization reaction in gel, compared with the same reaction in solution.

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Self-assembling of fibers inside an injectable calcium phosphate bone cement: a feasibility study

Cited by 7 publications

References 46 publications

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

A tough injectable self‐setting cement‐based hydrogel for noninvasive bone augmentation

Controlled Lactonization of o-Coumaric Esters Mediated by Supramolecular Gels

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