Self-assembling nanowires from a linear l,d-peptide conjugated to the dextran end group

Raganato, Luca; Giudice, Alessandra Del; Ceccucci, Anita; Sciubba, Fabio; Casciardi, Stefano; Sennato, Simona; Scipioni, Anita; Masci, Giancarlo

doi:10.1016/j.ijbiomac.2022.03.050

Cited by 4 publications

(4 citation statements)

References 70 publications

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“…Recently, Raganato et al reported for the first time the L, D-octapeptide-dextran conjugated compound DEX 29 -(L V D V ) 4 block conjugate [ 89 ]. The strong hydrogen bonds and hydrophobic interactions of the (L V D V ) 4 linear peptide promoted the self-assembly of the conjugated compounds to grow into 0.10–1 μm PNWs.…”

Section: Self-assembly Of Peptides Into Various Stimuli-responsive Su...mentioning

confidence: 99%

Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Mu,

Zhu,

Abdulmalik

et al. 2024

Bioactive Materials

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Section: Self-assembly Of Peptides Into Various Stimuli-responsive Su...mentioning

confidence: 99%

Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Mu,

Zhu,

Abdulmalik

et al. 2024

Bioactive Materials

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“…DEX contains a large number of hydroxyl groups which are capable of conjugating bioactive molecules by direct coupling or via a linker. DEX has been used to form hydrogels [ 10 , 11 , 12 ], films [ 13 , 96 ], nanosystems (by itself or as a coating agent) [ 5 , 6 , 9 , 15 , 16 ] and other systems [ 7 , 8 , 17 , 18 , 19 , 20 ], in order to release controllable amounts of drugs ( Table 2 ). Recently, it was demonstrated that DEX has a protective effect on cells against oxidative stress induced by drug cytotoxicity [ 28 , 42 ].…”

Section: Dextran Used In Drug-delivery Systemsmentioning

confidence: 99%

“…Over the last decades, a huge number of macromolecules, including natural polymers, were considered as constituents for drug-delivery systems (DDS) in different formulations: microspheres [ 1 , 2 ], microparticles [ 3 , 4 ], nanoparticles (NPs) [ 5 ], nanodroplets [ 6 ], liposomes [ 7 ], micelles [ 8 , 9 ] and nanomicelles [ 9 ], hydrogels [ 10 , 11 , 12 ], films [ 13 , 14 ], nanowires [ 15 ], bio-conjugates [ 16 ], medical adhesives [ 17 ] and others [ 18 , 19 , 20 ]. Among natural polymers, polysaccharides are one of the most utilised bio-polymers in DDS’s manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Petrovici¹,

Pinteala²,

Simiónescu

2023

Molecules

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Dextran is by far one of the most interesting non-toxic, bio-compatible macromolecules, an exopolysaccharide biosynthesized by lactic acid bacteria. It has been extensively used as a major component in many types of drug-delivery systems (DDS), which can be submitted to the next in-vivo testing stages, and may be proposed for clinical trials or pharmaceutical use approval. An important aspect to consider in order to maintain high DDS’ biocompatibility is the use of dextran obtained by fermentation processes and with a minimum chemical modification degree. By performing chemical modifications, artefacts can appear in the dextran spatial structure that can lead to decreased biocompatibility or even cytotoxicity. The present review aims to systematize DDS depending on the dextran type used and the biologically active compounds transported, in order to obtain desired therapeutic effects. So far, pure dextran and modified dextran such as acetalated, oxidised, carboxymethyl, diethylaminoethyl-dextran and dextran sulphate sodium, were used to develop several DDSs: microspheres, microparticles, nanoparticles, nanodroplets, liposomes, micelles and nanomicelles, hydrogels, films, nanowires, bio-conjugates, medical adhesives and others. The DDS are critically presented by structures, biocompatibility, drugs loaded and therapeutic points of view in order to highlight future therapeutic perspectives.

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“…5 Moreover, the primary sequence of peptides can be easily modified ad-hoc to modulate the structural and the functional properties of the resulting material. In this context, many different examples of peptide nanostructures (nanofibers, 6,7 nanowires, 8 nanotubes 9,10 and nanospheres 11 ) and soft materials (hydrogels 12–14 and hydrogel nanoparticles 15,16 ) have been proposed as delivery vehicles of therapeutics and/or diagnostic agents. The delivery of the active pharmaceutical ingredient (API) can be achieved according to different strategies, in which the API is covalently bound to the nanostructure or, as an alternative, physically encapsulated inside the nanostructure.…”

Section: Introductionmentioning

confidence: 99%