Self-assembling microparticles with controllable disruption properties based on cyclodextrin interactions

Nielsen, Anne Louise; Steffensen, Kim; Larsen, Kim Lambertsen

doi:10.1016/j.colsurfb.2009.05.023

Cited by 38 publications

(24 citation statements)

References 38 publications

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“…[18,19] Association of a poly(vinylpyrrolidone-co-bCD) and a benzoate-modified dextran led to particles in the nano/micrometer range. [20] Recently, we showed that polymer nanoassemblies may be obtained in pure water by simply mixing two neutral and hydrophilic polymers. The first polymer was a bCD/epichlorohydrin copolymer (with a branched architecture) which interacted via a ''lock and key'' mechanism with a hydrophobically modified dextran bearing low amounts of dodecyl moieties (typically 4-6 mol%).…”

Section: Introductionmentioning

confidence: 99%

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Wintgens

Nielsen

Larsen

et al. 2011

Macromolecular Bioscience

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Nanoassemblies formed by host/guest interactions between two polymers in aqueous media are studied. Two types of polymers with the same dextran backbone are modified with adamantyl or βCD groups. The sizes of the spontaneously formed nanoassemblies depend on the βCD:Ada ratio and on the total concentration and composition of the mixtures. The results can be rationalized by assuming a core/shell structure of the nanoassemblies, the core resulting from associative phase separation of the two polymers and being stabilized by an external shell made of Ada-grafted dextran and containing ions adsorbed from the solution. Hydrophobic compounds such as benzophenone can be incorporated efficiently without inducing changes in properties of the nanoassemblies.

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Section: Introductionmentioning

confidence: 99%

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Wintgens

Nielsen

Larsen

et al. 2011

Macromolecular Bioscience

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“…It is well known that cyclodextrin (CD) can form inclusion complexes with various hydrophobic drugs [13][14][15][16][17] . It is also well known that paclitaxel (PTX), one of the most common antitumour drugs [18][19][20] , forms an inclusion complex with beta-CD (b-CD), which results in a significant increase in the aqueous solubility of PTX [21][22][23][24][25][26] .…”

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confidence: 99%

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

et al. 2014

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Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

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“…those possessing a physical crosslinking, have attracted much attention lately. These hydrogels can be useful in pharmaceutical and biological applications, especially for some purposes as gene carriers or in the delivery of delicate bioactive agents such as drugs or proteins (Koopmans and Ritter, 2008, Li et al, 2006, Li and Loh, 2008, Lin et al, 2013, Ni et al, 2009, Nielsen et al, 2009, van de Manakker et al, 2008, Van Tomme et al, 2008, Wintgens et al, 2008. Among their promising properties, they present a quick degradation process and the capability of forming the gel "in situ" by physical crosslinking between molecules coming from different solutions.…”

Section: Introductionmentioning

confidence: 99%

“…In previous works, some authors have discovered that mixing PEO/PPO block copolymers with cyclodextrins (CD) produces self-assembled gels (Koopmans and Ritter, 2008, Li et al, 2006, Nielsen et al, 2009, Tan et al, 2012. Cyclodextrins are natural molecules derived from starch with a relatively hydrophobic cavity, which can form inclusion complexes with different molecules, including linear polymers (Dodziuk, 2006).…”

Section: Introductionmentioning

confidence: 99%

Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins

Larrañeta

Isasi

2014

Carbohydrate Polymers

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Different types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used. For each of their four diblock arms, direct Tetronic 904 presents PEO outer blocks while in reverse Tetronic 90R4 the hydrophilic PEO blocks are the inner ones. These gels were prepared by combining α-CD and poloxamine aqueous solutions.The physicochemical properties of these systems depend on several factors such as the structure of the block copolymers and the Tetronic/α-CD ratio. These gels were characterized using differential scanning calorimetry (DSC), viscometry and X-ray diffraction measurements. The 90R4 gels present a consistency that makes them suitable for sustained drug delivery. The resulting gels were easily eroded: these complexes were dismantled when placed in a large amount of water, so controlled release of entrapped large molecules such as proteins (Bovine Serum Albumin, BSA) is feasible and can be tuned by varying the copolymer/CD ratio. • The rheological behaviour of the poloxamine/α-cyclodextrin gels depend on the copolymer/ oligosaccharide ratio and the temperature.• Proteins or other molecules can be loaded into these supramolecular structures before gelation.• The resulting gels were easily eroded so controlled release of entrapped proteins is feasible and can be tuned by varying the copolymer/CD ratio.

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Self-assembling microparticles with controllable disruption properties based on cyclodextrin interactions

Cited by 38 publications

References 38 publications

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins

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