Self-assembling materials for therapeutic delivery

Abstract

A growing number of medications must be administered through parenteral delivery, i.e., intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the therapeutic. For some therapeutics, the use of delivery vehicles in conjunction with this delivery mechanism can improve drug efficacy and patient compliance. Macromolecular self-assembly has been exploited recently to engineer materials for the encapsulation and controlled delivery of therapeutics. Selfassembled materials offer the advantages of conventional crosslinked materials normally used for release, but also provide the ability to tailor specific bulk material properties, such as release profiles, at the molecular level via monomer design. As a result, the design of materials from the "bottom up" approach has generated a variety of supramolecular devices for biomedical applications. This review provides an overview of self-assembling molecules, their resultant structures, and their use in therapeutic delivery. It highlights the current progress in the design of polymer-and peptide-based self-assembled materials.

Controlled Delivery of Transforming Growth Factor β1 by Self-Assembling Peptide Hydrogels Induces Chondrogenesis of Bone Marrow Stromal Cells and Modulates Smad2/3 Signaling

“…[20][21][22][23][24] Benefits have been demonstrated for the use of these peptide hydrogels in cartilage, 25,26 liver, 27 and cardiovascular 28,29 tissues, and they have been shown to provide a microenvironment that enhances the chondrogenesis of BMSCs. 26,30 These peptides can also control the delivery and release of functional proteins, 21 therapeutic macromolecules, 22 and bioactive motifs.…”

Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system

“…이러한 문제를 해 결하기 위해 약물 방출을 제어할 수 있는 약물제형 시스 템 개발이 연구 중이며, 특히 약물제형 중 서방성 제제 로서 더욱 진보된 제형인 SDRS(sustained drug release system)에 대한 연구가 활발히 이루어지고 있다. 일반적 인 서방성제제로서 마이크로캡슐화, 매트릭스제형, 펠렛 형 등이 응용 연구되고 있다 [4,5]. 참 고 문 헌…”

Multicomponent Dipeptide Supramolecular Hydrogels as Fibronectin-Mimetic Biomaterials

“…Self-assembled supramolecular peptide hydrogels are important biomaterials that have been designed as matrices for tissue engineering and regenerative medicine [1][2][3][4]. Hydrogels derived from low molecular weight dipeptides or functionalized amino acids are a subset of self-assembled peptide hydrogels that have garnered significant recent interest [5][6][7].…”