“…25 Due to resemblance with amide moiety in size, dipolar moment, and H-bond acceptor capacity, the 1,2,3-triazole ring can serve as its non-classic bioisostere. 44,45,87,88 Since 1,2,3-triazoles are basic aromatic heterocyclic compounds, they are bioisosteres of aromatic rings and double bonds. 65,66 Additionally, the aforementioned physicochemical properties of 1,2,3-triazole moiety together with similarity to amide bond, make it a useful linker to generate "twin drugs", 42,67,83 bidentate inhibitors, [83][84][85]89 linkers to immobilized fluorescent tags or small molecules, 71 and anion receptors.…”