Self-Assembling Cavities: Present and Future

Chemical Encapsulation in Self‐Assembling Capsules

“…[8] For a detailed investigation of the factors that govern the assembly of such hosts and the encapsulation of guests, artificial, minimalistic models were designed. [9,10] These capsules consist of two (or four) identical, self-complementary mono-mers held together by hydrogen bonds. The first examples 1 5 1 -3 5 3 resembled a tennis ball ( Figure 1).…”

Amphiphilic p‐tert‐butylthiacalix[4]arenes containing quaternary ammonium groups: from small molecules toward water‐soluble nanoscale associates

“…It allows the nanoparticles to interact with substrates, for example, with biopolymers, with a high efficiency because of multiple simultaneous non‐covalent interactions. Nanosized structures formed by supramolecular self‐assembling and capable of interacting with biopolymers can be used as diagnostic systems, selective extractants, and drug delivery systems …”

“…There are many articles describing the formation of host–guest complexes, dimer capsules, supramolecular associates, nanosized particles based on calixarene molecules, and different types of substrates (metal cations, halogen anions, and small organic molecules) at various conditions . In our recent publications, we determined that p‐tert ‐butylthiacalix[4]arenes are able to form nanosized associates with cations of s ‐, p ‐, and d ‐elements and dicarboxylic acids in organic phase .…”

“…Nanosized structures formed by supramolecular self-assembling and capable of interacting with biopolymers can be used as diagnostic systems, selective extractants, and drug delivery systems. [30][31][32][33][34][35][36] Usually, the structure and properties of supramolecular particles can be predetermined by covalent synthesis of a receptor. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Synthetic macrocyclic platform, p-tert-butylthiacalix [4]arene, was specified for the synthesis of receptors.…”

Self-assembling Dimeric and Trimeric Aggregates Based on Solvophobic and Charge-pairing Interactions

“…Alternatively, mimicking nature is often performed to assemble functional supramolecular artificial systems [4 -9]. Over the past decade considerable attention had been given to the design and synthesis of selfassembled supramolecular capsules that are structurally stable in solution, because such assemblies mimic biorelevant self-association events that create discrete suprastructures through noncovalent interactions [10,11]. The two most common motifs use calixarenes [12 -15] and glycolurils as monomers [16 -18].…”