Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Prasanthan, Pooja; Kishore, Nand

doi:10.1039/d1ra03770f

Cited by 29 publications

(25 citation statements)

References 43 publications

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“…Unsurprisingly, CMC of copolymers dropped steadily during the increase in temperature (panels A and D of Figure and Table S1 of the Supporting Information). A comparison on temperature-dependent micellization of PEO–PPO-based block copolymers has shown a similar trend. , It is argued that their hydrophobicity increases, following the dehydration of PEO units at elevated temperatures. Higher CMC of T1307 can be understood by taking into account its strong affinity for water molecules.…”

Section: Resultsmentioning

confidence: 82%

“…A comparison on temperature-dependent micellization of PEO−PPO-based block copolymers has shown a similar trend. 23,34 It is argued that their hydrophobicity increases, following the dehydration of PEO units at elevated temperatures. Higher CMC of T1307 can be understood by taking into account its strong affinity for water molecules.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Data points above and below CMC in the enthalpy curve were fitted through linear regression. The intersection point of these extrapolated lines was demarcated as CMC′ (Figure S2 of the Supporting Information). , …”

Section: Methodsmentioning

confidence: 99%

“…The intersection point of these extrapolated lines was demarcated as CMC′ (Figure S2 of the Supporting Information). 23,24 Gibbs free energy of micellization (ΔG mic ) and entropy of micellization (ΔS mic ) were calculated from the following equations:…”

Section: ■ Introductionmentioning

confidence: 99%

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Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

et al. 2023

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We present a comprehensive investigation on the interaction of tetronics (T1304 and T1307) with some important physiological salts (NaH2PO4, KH2PO4, Na2CO3, NaCl, and KI). Thermodynamic and microstructural aspects of these interactions were studied as a function of the solution temperature, pH and salt concentration. Characterizations were performed using turbidimetric, calorimetric, and scattering techniques. We show that, at ambient temperature, T1304 molecules aggregated to form spherical core–shell aggregates displaying a unimodal distribution pattern. On the other hand, unimers and large clusters dominated in the case of highly hydrophilic T1307. Its micellization was promoted in the presence of salts as per the following trend: NaCl < KH2PO4 < NaH2PO4 ≪ Na2CO3. Aggregation was found to be endothermic, and hydrophobic interactions (TΔS mic > ΔH mic) prevailed. The enthalpy–entropy compensation plot was found to be linear for both copolymers. Demicellization occurred in the presence of KI as it facilitated the buildup of water structures around the copolymer chains. This could be verified from the increase in the cloud point, critical micelle concentration, and free energy. Overall, the temperature and salts inflicted a stronger hydrophobic effect upon T1304 in comparison to T1307.

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Section: Resultsmentioning

confidence: 82%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

et al. 2023

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“…10,11 For the specific Pluronic F127 (PEO106-PPO70-PEO106), frequently used in bacteira encapsulation and also for the experiments in this article, the critical micellar concentration (cmc) is at 0.725 wt. % in water at 25 °C [12][13][14] , and the sol-gel transition occurs at polymer concentrations > 5 wt. % and temperatures above 14 °C.…”

Section: Introductionmentioning

confidence: 99%

Rheological behavior of Pluronic/Pluronic diacrylate hydrogels used for bacteria encapsulation

Bhusari

Hoffmann

Herbeck-Engel

et al. 2023

Preprint

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Pluronic (Plu)-based hydrogels containing a fraction of Pluronic diacrylate (PluDA) chains form physical networks with additional covalent crosslinks. These hydrogels have been used to encapsulate bacteria or yeast in living materials and devices. Within Plu/PluDA hydrogels, the growth of the encapsulated organisms decreases with increasing density of covalent bonds. This has been attributed to the capability of the organisms to sense and respond to the mechanical properties of the embedding matrix. Here we investigate the rheological behavior of 30 wt. % Plu/PluDA hydrogels with increasing covalent crosslinking adjusted by the PluDA fraction in the mixture. This hydrogel composition allowed hydrogel-regulated growth of E. coli in living devices in previous reports. We aim to find experimental descriptors of the hydrogel's rheological response that can be correlated to the reported growth behavior. We present stress relaxation and creep-recovery experiments and quantify the elastic, viscoelastic and plastic responses of the hydrogels as function of the covalent crosslinking degree, with a focus on critical yield strain/stress and relaxation parameters. An inverse correlation was observed between the storage modulus and the critical stress/strain for fluidization TF, of the hydrogel and the reported maximum volume of E. coli colonies grown in the hydrogels. These results contribute to the biophysical understanding of bacteria behavior in confinement and are relevant for different application contexts, eg. to improve the performance and safety of living therapeutic implants and to maximize the yield of biotechnological production in immobilized cell reactors.

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Design and Synthesis of Cabazitaxel Loaded Core‐Shell Mesoporous Silica Nanoparticles with Different Morphologies for Prostate Cancer Therapy

Mohanan

Sathish

Ramadass

et al. 2023

Small

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In this work, the synthesis of core‐shell ordered mesoporous silica nanoparticles (CSMS) with tunable particle size and shape through a dual surfactant‐assisted approach is demonstrated. By varying the synthesis conditions, including the type of the solvent and the concentration of the surfactant, monodispersed and ordered mesoporous silica nanoparticles with tunable particle size (140–600 nm) and morphologies (hexagonal prism (HP), oblong, spherical, and hollow‐core) can be realized. Comparative studies of the Cabazitaxel (CBZ)‐loaded HP and spherical‐shaped CSMS are conducted to evaluate their drug delivery efficiency to PC3 (prostate cancer) cell lines. These nanoparticles showed good biocompatibility and displayed a faster drug release at acidic pH than at basic pH. The cellular uptake of CSMS measured using confocal microscopy, flow cytometry, microplate reader, and ICP‐MS (inductively coupled plasma mass spectrometry) techniques in PC3 cell lines revealed a better uptake of CSMS with HP morphology than its spherical counterparts. Cytotoxicity study showed that the anticancer activity of CBZ is improved with a higher free radical production when loaded onto CSMS. These unique materials with tunable morphology can serve as an excellent drug delivery system and will have potential applications for treating various cancers.

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Self-assemblies of pluronic micelles in partitioning of anticancer drugs and effectiveness of this system towards target protein

Abstract: Micelles formed by pluronic triblock copolymers are known to be a promising class of drug delivery vehicles.

Cited by 29 publications

References 43 publications

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

Comparative Effect of Physiological Salts upon Micellization of T1304 and T1307

Rheological behavior of Pluronic/Pluronic diacrylate hydrogels used for bacteria encapsulation

Design and Synthesis of Cabazitaxel Loaded Core‐Shell Mesoporous Silica Nanoparticles with Different Morphologies for Prostate Cancer Therapy

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