Self-Assemblies Behaviour of Palm Oil-Based Galactoside

Abstract

Analyses of palm kernel oil-based galactosides self-assemblies are important to determine their applications in pharmaceutical products. The palm kernel oil-based galactosides (GalPKO) are synthesized by adopting Fischer glycosylation method with minor modification. A birefringent fan-shaped texture was observed upon cooling using optical polarizing microscope (OPM) indicates formation of a smectic phase. The galactosides form isotropic phase completely at 137 °C. Water contact penetration showed that GalPKO does not form other lyotropic system except hydrated smectic phase. Based on its lyotropic behavior, critical aggregation concentration (CAC) is determined at value 0.11 mM indicating low solubility of the galactosides in water. Based on finding, galactoside can form a special class of liquid crystal mesophases and give a variety interesting application.Keywords: galactoside, thermotropic, lyotropic, liquid crystal, mesophase Abstrak Analisa swapenyusunan galaktosida berasaskan minyak kernel sawit penting bagi menentukan aplikasinya dalam produk farmaseutikal. Galaktosida berasaskan minyak kernel sawit (GalPKO) disintesis menggunakan kaedah Fischer glikosilasi yang diubahsuai. Tekstur birefringen berbentuk seperti kipas diperhatikan menggunakan mikroskop polarisasi optik (OPM) semasa proses penyejukan sampel, menunjukkan pembentukan fasa smektik. Galaktosida membentuk fasa isotropik sepenuhnya pada 137 °C. Penyerapan air menunjukkan bahawa GalPKO hanya membentuk sistem liatropik fasa smektik terhidrat. Berdasarkan sifat liotropik itu, kepekatan gumpalan kritikal (CAC) ditentukan pada 0.11 mM menunjukkan keterlarutan galaktosida dalam air yang memuaskan. Hasil penyelidikan menunjukkan galatoksida ini bakal membentuk satu kelas khas fasameso cecair hablur serta kemungkinan dalam pelbagai aplikasi menarik.