Self-assembled polymeric nanoparticles based on oleic acid-grafted chitosan oligosaccharide: biocompatibility, protein adsorption and cellular uptake

Chen, Xi Guang; Huang, Lü; Han, Jing Tian; Zhang, Xiao Fan

doi:10.1007/s10856-012-4651-1

Cited by 32 publications

(32 citation statements)

References 36 publications

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“…One phenomenon easy to find in many cell lines is the reduction in the ability to produce formazan deposits even when NPs are incubated at a sublethal dose. [69][70][71] This result is intended as an index of mitochondrial stress, since the reaction involved in the formazan formation is catalyzed by a mitochondrial reductase. It has been demonstrated that a perturbation of the normal mitochondrial activity is correlated with an increase in reactive oxygen species (ROS) production.…”

Section: Effects Of Nanoparticles On Cellular Physiologymentioning

confidence: 99%

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

Panariti¹,

Miserocchi²,

Rivolta³

2012

NSA

170

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Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important players in current research in modern medicine. In the last few decades, several types of NPs and microparticles have been synthesized and proposed for use as contrast agents for diagnostics and imaging and for drug delivery; for example, in cancer therapy. Yet specific targeting that will improve their delivery still represents an unsolved challenge. The mechanism by which NPs enter the cell has important implications not only for their fate but also for their impact on biological systems. Several papers in the literature discuss the potential risks related to NP exposure, and more recently the concept that even sublethal doses of NPs may elicit a cell response has been proposed. In this review, we intend to present an overall view of cell mechanisms that may be perturbed by cell-NP interaction. Published data, in fact, emphasize that NPs should no longer be viewed only as simple carriers for biomedical applications, but that they can also play an active role in mediating biological effects.

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Section: Effects Of Nanoparticles On Cellular Physiologymentioning

confidence: 99%

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

Panariti¹,

Miserocchi²,

Rivolta³

2012

NSA

170

View full text Add to dashboard Cite

show abstract

“…This also suggests that altering or manipulating the surface chemistry will aid in increased or decreased uptake of nanoparticles by the cells and also increases the circulation time in blood [55,57]. Adsorption of plasma proteins on nanoparticles enhances its stability by reducing agglomeration, drug carrier efficiency and also increases its compatibility with the biological system [35,58]. Thus our results indicate that LaNRs are biocompatible as revealed through BSA adsorption and can be efficiently used for therapeutic purposes.…”

Section: Protein Adsorptionmentioning

confidence: 59%

“…Particles were then washed to remove excess BSA by centrifugation at 14,000 rpm for 15 min. The protein was desorbed from the surface of LaNRs by sonication in the presence of PBS containing 1 % SDS [35]. The samples were subjected to 10 % SDS-PAGE [36] and stained with Coomassie Brilliant Blue R-250 (Merck, India).…”

Section: Protein Adsorption Studymentioning

confidence: 99%

Ultrasonic mediated synthesis of monodispersed lanthanum hydroxide nanorods for possible bioimplant application

Dhandapani

Rajaram

2015

J Mater Sci: Mater Med

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Monodispersed lanthanum hydroxide nano-rods (LaNRs) were synthesized for prospective biomedical application using a microwave heating and ultrasonic agitation methodology which does not require any toxic stabilizing agent. The average length and diameter of the LaNRs thus obtained were 183.4 ± 3.6 and 9.9 ± 0.2 nm respectively, as analyzed by HRTEM. FTIR spectrum confirmed the presence of OH groups. The thermal transformation of lanthanum hydroxide (La(OH)3) was studied by thermogravimetric analysis. The synthesized LaNRs were found to be stable for a period of 1 month at room temperature. They were biocompatible as evaluated by haemocompatibility assay and viability assay using human peripheral blood mononuclear cells. The pro-angiogenic property of LaNRs was demonstrated by in vivo chick chorioallantoic membrane assay. The LaNRs induced osteoblast differentiation of human adipose derived stem cells with significant calcium (Ca(2+)) deposition indicating potential applications in bone tissue engineering.

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“…Previously, Zhang et al . illustrated the development of oleic acid grafted chitosan oligosaccharide and used as drug carrier, however, did not discuss about the micellization behavior . Li et al .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of RAFT‐Mediated Amphiphilic Graft Copolymeric Micelle Using Dextran and Poly (Oleic Acid) toward Oral Delivery of Nifedipine

Karmakar

Seesala

Pal

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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A novel, pH‐responsive supramolecular graft copolymeric micelle, composed of dextran and poly (oleic acid), has been synthesized through reversible addition fragmentation chain transfer polymerization with controlled Mn and narrow polydispersity. The structural properties of the copolymer have been studied using FTIR and 1H NMR spectral analyses. Critical micelle concentration (CMC) has been determined fluorometrically and conductometrically. The copolymer shows pH responsive micellar stability, which has been confirmed using DLS study. Dextran‐g‐OA copolymer demonstrates spherical morphology at CMC, while rod‐like assembly has been evidenced beyond CMC that is probably because of the structural alteration of copolymeric chains at higher copolymer concentration. Dextran‐g‐OA is noncytotoxic toward MG‐63 cells. As the self‐assemble nature of copolymer micelle promotes the oral administration of hydrophobic drugs, nifedipine (NFD, a hydrophobic drug) has been used as model drug that has been encapsulated substantially into the core of the micelle. The copolymer releases the loaded NFD at a much slower rate in simulated gastric fluid (pH 1.2) and relatively faster in simulated intestinal fluid (pH 7.4) with a cumulative release of ~95% within 24 h, suggesting an ideal candidate as nifedipine carrier. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2354–2363

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Self-assembled polymeric nanoparticles based on oleic acid-grafted chitosan oligosaccharide: biocompatibility, protein adsorption and cellular uptake

Cited by 32 publications

References 36 publications

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

Ultrasonic mediated synthesis of monodispersed lanthanum hydroxide nanorods for possible bioimplant application

Synthesis of RAFT‐Mediated Amphiphilic Graft Copolymeric Micelle Using Dextran and Poly (Oleic Acid) toward Oral Delivery of Nifedipine

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