Self-assembled peptidic nanostructures

Abstract

Cataloged from PDF version of article.Understanding the mechanisms of molecular self-assembly processes in natural\ud materials is an important step to developing new functional materials with useful properties.\ud Recently, various self-assembled materials have gained attention because of their interesting\ud properties in nanoscale. Nanostructures composed of peptides are especially of interest\ud in materials development because of their many advantageous properties such as biodegradability,\ud biocompatibility and customizable bioactivity. Self-assembled peptidic nanostructures\ud have been studied by many research groups and found use as three-dimensional cell scaffolds\ud for bone regeneration, dental implants, neural tissue engineering, biosensors for detection of\ud viruses and other pathogens, antibacterial agents and in drug, protein and gene delivery

Peptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agents

“…The hydrophilic peptide segment of the PA molecule is exposed at the exterior part of the SPIONs and provides stability and bioactivity in aqueous conditions. 17 The PAs can be modified by various peptide sequences for targeting desired cell types and/or molecules. The optimum ratio for the synthesis of the peptide-SPION complex was found to be 7 mg PA to 1 mg SPION and the optimum volume for the mixture is 10 ml PA solution in water to 1 ml of SPIONs in hexane.…”

Nanomaterials for neural tissue engineering

“…Numerous types of SA process are carried out in nature. Amino acids, fatty acids, and other molecules come together to form self-assembled nano or larger structures (Toksoz and Guler, 2009 ).…”

Self-assembled micelles of amphiphilic poly(L-phenylalanine)-b-poly(L-serine) polypeptides for tumor-targeted delivery

“…Moreover, some peptides with particular sequences, acting as signal peptides or the recognition units of particular receptors, can induce specific interactions with cells. 6,7 Amphiphilic polypeptides or polyamino acids have been developed to form various nanostructures, such as nanotubes, 8,9 nanofibers, 10,11 and micellar nanoparticles (MNPs). 12,13 Compared with other architectures, MNPs are more suitable for antitumor drug carriers.…”