Self-assembled nanotubes from single fluorescent amino acid

Babar, Dipak Gorakh; Sarkar, Sabyasachi

doi:10.1007/s13204-017-0551-5

Cited by 47 publications

(71 citation statements)

References 43 publications

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“…It has also been reported that by changing the amount of water volume, there would be a change in the shape of the final product from nanotube to nanowire [36,42] . Generally, in the present study, the presence of hydrogen bonding and π ‐ π stacking interactions for minimizing the surface energy lead to the formation of the phenylalanine amino acids tubes [20] . Therefore, the medium concentration (0.5 mg/ml) is the optimal concentration of phenylalanine solution for the synthesis of nanotubes as an ideal drug nanocarrier.…”

Section: Resultssupporting

confidence: 53%

“…As a result, in the ring deformation region of around 840–500 cm −1 , some certain changes are taken place which further suggest the interactions of π ‐ π and C−H− π . Moreover, OH and CH stretching vibrations indicate their peaks at 3226 cm −1 and 3839 cm −1 and at 2670 cm −1 , respectively [20,49] …”

Section: Resultsmentioning

confidence: 99%

“…In addition, they can easily penetrate into the cellular membrane and have better flow dynamics than spherical nanoparticles [14] . Carbon, [15] silica, [16] lipids, [17] proteins, [18] peptides [19] and amino‐acids [20] are the most common materials for the synthesis of nanotube structures in drug delivery and biomedical applications, [21] among which, peptides and amino acids are the primary materials for the fabrication of nanotubes. These types of biomaterials have various advantages over carbon nanotubes; they are soluble in water and can be easily synthesized.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Phenylalanine Nanotubes as Green pH‐Responsive Drug Nanocarriers

et al. 2020

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The present study is aiming to investigate the potential of phenylalanine amino acid nanotubes (PhNTs) synthesized by a self‐assembly process as an efficient and pH‐responsive green drug nanocarrier for the treatment of oral disease. Phenylalanine was used for the preparation of solutions with three different concentrations (0.1, 0.5 and 2.5 mg/ml). Scanning electron microscopy (SEM) and Field emission scanning electron microscopy (FESEM) images showed that low and high concentrations of phenylalanine solution creates nanospheres and nanowires, respectively rather than tubular‐shaped nanostructures. In contrast, phenylalanine nanotubes were synthesized by medium concentration (0.5 mg/ml). The tubular shape and nanoscale diameter of the synthesized PhNTs were characterized by FESEM, Transmission Electron microscopy (TEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR). These characterization tests confirmed the synthesis of PhNTs with a tubular shape and nanoscale diameter. In the second stage, metronidazole was loaded into the phenylalanine‐based nanostructures as an effective drug for oral disorders. The results indicated that nanospheres and nanowires show drug loading efficiency of 49 % and 58 %, respectively, after 48 h of incubation time. Whereas, the drug loading efficiency for nanotubes was 91 %. The results from the FTIR analysis and UV‐vis spectroscopy verified the presence of metronidazole into the hollow structure of PhNT. While a burst drug release was observed for nanospheres and nanowires, PhNTs showed a well‐controlled release of metronidazole up to 95 % at oral pH, which is best fitted to the Weibull model. Subsequently, the cell viability of phenylalanine‐based nanostructures was assessed by MTT test on L929 fibroblast cell line.

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Section: Resultssupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Phenylalanine Nanotubes as Green pH‐Responsive Drug Nanocarriers

et al. 2020

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“…[35] These nanotubes exhibited fluorescence when excited at 385 (blue), 488 (yellow) and 561 (red) nm.…”

Section: Amino Acid Based Nanostructuresmentioning

confidence: 99%

“…[14c] (I) FESEM images of Trp nanotubes (scale bar 200 nm). [35] Figures reproduced with permission from respective references.…”

Section: Figurementioning

confidence: 99%

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Chakraborty

Gazit

2018

ChemNanoMat

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Amino acids are the simplest biological building blocks capable of forming discreet nanostructures by supramolecular self-assembly. The understanding of the process of organization of amino acid nanostructures is of fundamental importance for the study of metabolic diseases as well as for materials science applications. Although peptide self-assembled structures have been the topic of many review articles, much less attention has been devoted to the ability of amino acid building blocks, both natural and synthetic, to form ordered assemblies with defined architectures and notable physical properties, by the process of self-association. Herein, we try to shed light on amino acid based nanostructures, their fabrication and implications. We discuss self-assembled nanostructures, including hydrogels with nanoscale order, obtained from both modified and unmodified single amino acids. We also envision some future prospects in this emerging field.

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Tailor‐Made Functional Peptide Self‐Assembling Nanostructures

et al. 2018

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Noncovalent interactions are the main driving force in the folding of proteins into a 3D functional structure. Motivated by the wish to reveal the mechanisms of the associated self-assembly processes, scientists are focusing on studying self-assembly processes of short protein segments (peptides). While this research has led to major advances in the understanding of biological and pathological process, only in recent years has the applicative potential of the resulting self-assembled peptide assemblies started to be explored. Here, major advances in the development of biomimetic supramolecular peptide assemblies as coatings, gels, and as electroactive materials, are highlighted. The guiding lines for the design of helical peptides, β strand peptides, as well as surface binding monolayer-forming peptides that can be utilized for a specific function are highlighted. Examples of their applications in diverse immerging applications in, e.g., ecology, biomedicine, and electronics, are described. Taking into account that, in addition to extraordinary design flexibility, these materials are naturally biocompatible and ecologically friendly, and their production is cost effective, the emergence of devices incorporating these biomimetic materials in the market is envisioned in the near future.

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Self-assembled nanotubes from single fluorescent amino acid

Cited by 47 publications

References 43 publications

Synthesis and Characterization of Phenylalanine Nanotubes as Green pH‐Responsive Drug Nanocarriers

Synthesis and Characterization of Phenylalanine Nanotubes as Green pH‐Responsive Drug Nanocarriers

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Tailor‐Made Functional Peptide Self‐Assembling Nanostructures

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