Self-assembled nanomaterials

García, Mónica Cristina; Aloisio, Carolina; Onnainty, Renée; Ullio-Gamboa, Gabriela

doi:10.1016/b978-0-08-100716-7.00003-9

Cited by 12 publications

(6 citation statements)

References 249 publications

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“…Advanced nanomaterial therapeutic systems have several advantages over conventional therapeutic systems. Targeted delivery of drugs to specific sites of action constitutes a promising alternative in order to overcome the current limitations of drugs [ 1 ] and comprises a big challenge for researchers in the field of pharmaceutical sciences, which have witnessed great progress in the development of improved drug delivery systems, including lipid-based and polymer-based carriers [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery

et al. 2021

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Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance of gold nanoparticles (AuNPs)-functionalized L for controlled doxorubicin (D) delivery. Their interfacial and morphological properties, drug release behavior against temperature changes and cytotoxic activity against breast and ovarian cancer cells were studied. Langmuir isotherms were performed to identify the most stable combination of lipid components. Two mole fractions of cholesterol (3.35 mol% and 40 mol%, L1 and L2 series, respectively) were evaluated. Thin-film hydration and transmembrane pH-gradient methods were used for preparing the L and for D loading, respectively. The cationic surface of L allowed the anchoring of negatively charged AuNPs by electrostatic interactions, even inducing a shift in the zeta potential of the L2 series. L exhibited nanometric sizes and spherical shape. The higher the proportion of cholesterol, the higher the drug loading. D was released in a controlled manner by diffusion-controlled mechanisms, and the proportions of cholesterol and temperature of release media influenced its release profiles. D-encapsulated L preserved its antiproliferative activity against cancer cells. The developed liposomal formulations exhibit promising properties for cancer treatment and potential for hyperthermia therapy.

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Section: Introductionmentioning

confidence: 99%

Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery

et al. 2021

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“…4,5 Capsules are often vesicular systems with liquid core (consisting of water or oil) acting as a drug reservoir, surrounded by a protecting shell. 6 Polymeric micelles are self-assembled structures built out of amphiphilic copolymers. In aqueous media, hydrophilic groups form an outer shell and hydrophobic fragments face the core in which the lipophilic drug can be encapsulated.…”

Section: Introductionmentioning

confidence: 99%

“…In aqueous media, hydrophilic groups form an outer shell and hydrophobic fragments face the core in which the lipophilic drug can be encapsulated. 6,7 Polymeric micelles are typically more stable compared to traditional surfactant-based micelles. 6,8 They also have an advantage over liposomes, because hydrophobic medications incorporated into the lipid bilayer tend to be released quite rapidly after systemic administration.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 Polymeric micelles are typically more stable compared to traditional surfactant-based micelles. 6,8 They also have an advantage over liposomes, because hydrophobic medications incorporated into the lipid bilayer tend to be released quite rapidly after systemic administration. 9 Polymer structures do not only retain the drug longer, but also have better loading capacity than micelles and liposomes.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric capsules and micelles as promising carriers of anticancer drugs

Kubiak¹

2022

Polim. Med.

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“…Such nanoscale materials possess unique electrical, optical as well as biological properties and are thus applied in catalysis, biosensing, imaging, drug and delivery [2][3]. Silver nanoparticles are essential materials that have been studied extensively, especially the formation of anisotropic 1D arrays by the association of their collective properties [4]. The "bottom-up" synthesis approach of nanomaterials first forms the nanostructured units, and then assembles to obtain the final material [5].…”

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confidence: 99%