Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

Sabra, Sally; Abdelmoneem, Mona A.; Abd-Elwakil, Mahmoud M.; Mabrouk, Moustafa T.; Anwar, Doaa M.; Mohamed, Rania Hassan; Khattab, Sherine N.; Bekhit, Adnan A.; Elkhodairy, Kadria A.; Freag, May S.; Elzoghby, Ahmed O.

doi:10.2174/1381612823666170526111029

Cited by 33 publications

(24 citation statements)

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“…Nanocarriers fabricated from natural polymers including proteins and polysaccharides offer various opportunities for tumor-targeted drug delivery applications [30–32]. Albumin can be used as a drug carrier either by incorporation of the drug within its matrix or by conjugation to the functional groups available on the NPs surface.…”

Section: Resultsmentioning

confidence: 99%

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin–QDs nano-hybrids: covalent coupling and phospholipid complexation approaches

et al. 2019

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BackgroundThe rationale of this study is to combine the merits of both albumin nanoparticles and quantum dots (QDs) in improved drug tumor accumulation and strong fluorescence imaging capability into one carrier. However, premature drug release from protein nanoparticles and high toxicity of QDs due to heavy metal leakage are among challenging hurdles. Following this platform, we developed cancer nano-theranostics by coupling biocompatible albumin backbone to CdTe QDs and mannose moieties to enhance tumor targeting and reduce QDs toxicity. The chemotherapeutic water soluble drug pemetrexed (PMT) was conjugated via tumor-cleavable bond to the albumin backbone for tumor site-specific release. In combination, the herbal hydrophobic drug resveratrol (RSV) was preformulated as phospholipid complex which enabled its physical encapsulation into albumin nanoparticles.ResultsAlbumin–QDs theranostics showed enhanced cytotoxicity and internalization into breast cancer cells that could be traced by virtue of their high fluorescence quantum yield and excellent imaging capacity. In vivo, the nanocarriers demonstrated superior anti-tumor effects including reduced tumor volume, increased apoptosis, and inhibited angiogenesis in addition to non-immunogenic response. Moreover, in vivo bioimaging test demonstrated excellent tumor-specific accumulation of targeted nanocarriers via QDs-mediated fluorescence.ConclusionMannose-grafted strategy and QD-fluorescence capability were beneficial to deliver albumin nanocarriers to tumor tissues and then to release the anticancer drugs for killing cancer cells as well as enabling tumor imaging facility. Overall, we believe albumin–QDs nanoplatform could be a potential nano-theranostic for bioimaging and targeted breast cancer therapy.Electronic supplementary materialThe online version of this article (10.1186/s12951-019-0445-7) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin–QDs nano-hybrids: covalent coupling and phospholipid complexation approaches

et al. 2019

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“…Many surfactants and synthetic co -polymers are known to form micelles, but these micelles are usually toxic and unstable at physiological conditions [ 107 ]. As an alternative, natural proteins such as lactoferrin could be utilized instead of these synthetic polymers to fabricate micelles because of their known low immunogenicity, high biocompatibility and possibility of active targeting [ 108 ].…”

Section: Lactoferrin In Nanotechnologymentioning

confidence: 99%

Lactoferrin, a unique molecule with diverse therapeutical and nanotechnological applications

Sabra

Agwa

2020

International Journal of Biological Macromolecules

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Lactoferrin (LF) is a naturally glycoprotein with iron-binding properties and diverse biological applications including; antiviral, anti-inflammatory, antioxidant, anti-cancer and immune stimulating effects. In addition, LF was found to be an ideal nanocarrier for some hydrophobic therapeutics because of its active targeting potential due to overexpression of its receptor on the surface of many cells. Moreover, it was proven to be a good candidate for fabrication of nanocarriers to specifically deliver drugs in case of brain tumors owing to the capability of LF to cross the blood brain barrier (BBB). Consequently, it seems to be a promising molecule with multiple applications in the field of cancer therapy and nanomedicine.

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“…Drug carrier can be decorated with specific targeting ligands in order to recognize the overexpressed receptors on tumor cells [ 139 ], paving the way for novel strategies for efficient and specific targeting ( Figure 4 B). This strategy is often used to target TICs/CSCs.…”

Section: Atra Delivery Strategies: Moving Forwardmentioning

confidence: 99%

Current Trends in ATRA Delivery for Cancer Therapy

et al. 2020

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All-Trans Retinoic Acid (ATRA) is the most active metabolite of vitamin A. It is critically involved in the regulation of multiple processes, such as cell differentiation and apoptosis, by activating specific genomic pathways or by influencing key signaling proteins. Furthermore, mounting evidence highlights the anti-tumor activity of this compound. Notably, oral administration of ATRA is the first choice treatment in Acute Promyelocytic Leukemia (APL) in adults and NeuroBlastoma (NB) in children. Regrettably, the promising results obtained for these diseases have not been translated yet into the clinics for solid tumors. This is mainly due to ATRA-resistance developed by cancer cells and to ineffective delivery and targeting. This up-to-date review deals with recent studies on different ATRA-loaded Drug Delivery Systems (DDSs) development and application on several tumor models. Moreover, patents, pre-clinical, and clinical studies are also reviewed. To sum up, the main aim of this in-depth review is to provide a detailed overview of the several attempts which have been made in the recent years to ameliorate ATRA delivery and targeting in cancer.

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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

Abstract: Micellar nanocarriers fabricated from amphiphilic natural polymers hold great promise as vehicles for anti-cancer drugs.

Cited by 33 publications

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Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin–QDs nano-hybrids: covalent coupling and phospholipid complexation approaches

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin–QDs nano-hybrids: covalent coupling and phospholipid complexation approaches

Lactoferrin, a unique molecule with diverse therapeutical and nanotechnological applications

Current Trends in ATRA Delivery for Cancer Therapy

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