Self‐Assembled Multilayered Coatings with Multiple Cyclic Self‐Healing Capability, Bacteria Killing, Osteogenesis, and Angiogenesis Properties on Magnesium Alloys

Zhao, Yanbin; He, Peng; Yao, Junyan; Li, Mei; Bai, Jing; Xue, Feng; Chu, Chenglin; Cong, Yu; Chu, Paul K.

doi:10.1002/adhm.202302519

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…ALP is a metalloenzyme that catalyzes the hydrolysis of phosphomonoesters such as polyphosphates. It plays a vital role in hard tissue formation due to its increased expression in mineralized tissue cells [22,25], and is use as a relevant indicator of osteoblast differentiation [33,34]. The current study measured ALP activity in different mediums and concentrations, which were chosen based on pilot studies and adjusted to be within the range of activity of a test based on thymolphthalein monophosphate hydrolysis, to enable the identification of the most appropriate method of incorporating it into bleaching gels containing CaPP [16].…”

Section: Discussionmentioning

confidence: 99%

Enzymatically Driven Mineralization of a Calcium–Polyphosphate Bleaching Gel

Ortiz,

Corrales Ureña,

Aguiar

et al. 2024

Bioengineering

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To examined alkaline phosphatase enzyme (ALP) activity and the effects of incorporating it in the thickener solution of a hydrogen-peroxide-based bleaching gel containing calcium-polyphosphate (CaPP) on the orthophosphate (PO43−) levels, bleaching effectiveness, and enamel microhardness. ALP activity was assessed at different pH levels and H2O2 concentrations, and in H2O- and Tris-based thickeners. Circular dichroism (CD) was used to examine the ALP secondary structure in water-, Tris-, or H2O2-based mediums. The PO43− levels were evaluated in thickeners with and without ALP. Enamel/dentin specimens were allocated into the following groups: control (without bleaching); commercial (Whiteness-HP-Maxx); Exp-H (H2O-based); CaPP-H; ALP-H (CaPP+ALP); Exp-T (Tris-based); CaPP-T; and ALP-T (CaPP+ALP). Color changes (ΔE/ΔE00) and the bleaching index (ΔWID) were calculated, and surface (SMH) and cross-sectional microhardness (CSMH) were assessed. The two-way ANOVA and Tukey’s post-hoc tests were used to compare ALP and PO43− levels; generalized linear models were used to examine: ΔE/ΔE00/SMH/CSMH; and Kruskal–Wallis and Dunn’s tests were used for ΔWID (α = 5%). The ALP activity was higher at pH 9, lower in H2O2-based mediums, and similar in both thickeners. The CD-spectra indicated denaturation of the enzyme upon contact with H2O2. The PO43− levels were higher after incorporating ALP, and the ΔE/ΔE00/ΔWID were comparable among bleached groups. SMH was lower after bleaching in Exp-H, while CSMH was highest in ALP-T.

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Section: Discussionmentioning

confidence: 99%

Enzymatically Driven Mineralization of a Calcium–Polyphosphate Bleaching Gel

Ortiz,

Corrales Ureña,

Aguiar

et al. 2024

Bioengineering

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Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Wang,

Zhang,

Qiang

et al. 2024

Adv Healthcare Materials

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Surgical resection of bone tumors is the primary approach employed in the treatment of bone cancer. Simultaneously, perioperative interventions, particularly postoperative adjuvant anticancer strategies, play a crucial role in achieving satisfactory therapeutic outcomes. However, the occurrence of postoperative bone tumor recurrence, metastasis, extensive bone defects, and infection are significant risks that can result in unfavorable prognoses or even treatment failure. In recent years, there has been significant progress in the development of biomaterials, leading to the emergence of new treatment options for bone tumor therapy and bone regeneration. This progress report aims to comprehensively analyze the strategic development of unique therapeutic biomaterials with inherent healing properties and bioactive capabilities for bone tissue regeneration. These composite biomaterials, classified into metallic, inorganic non‐metallic, and organic types, are thoroughly investigated for their responses to external stimuli such as light or magnetic fields, internal interventions including chemotherapy or catalytic therapy, and combination therapy, as well as their role in bone regeneration. Additionally, we provide an overview of self‐healing materials for osteogenesis and explore their potential applications in combating osteosarcoma and promoting bone formation. Furthermore, we address the safety concerns of integrated materials and current limitations, while also discussing the challenges and future prospects.This article is protected by copyright. All rights reserved

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An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

Zhao,

Li,

Wang

et al. 2024

Adv Healthcare Materials

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Magnesium phosphate bone cement (MPC) has gained widespread usage in orthopedic implantation due to its fast‐setting and high initial strength benefits. However, the simultaneous attainment of drug‐controlled release and osteogenic potential in MPC remains a significant challenge. Herein, we proposed a strategy to create a smart injectable cement system using nanocontainers and chondroitin sulfate. It employed nanocontainers containing alendronate‐loaded mesoporous silica nanoparticles, which had been surface‐modified with polypyrrole to control drug release in response to near infrared (NIR) stimulation. The alendronate‐incorporated cement (ACMPC) exhibited improved compressive strength (70.6 ± 5.9 MPa), prolonged setting time (913 s), and exceptional injectability (96.5% of injection rate and 242 s of injection time). It also showed the capability to prevent degradation, thus preserving mechanical properties. Under NIR irradiation, the cement showed good antibacterial properties due to the combined impact of hyperthermia, reactive oxygen species, and alendronate. Furthermore, ACMPC (NIR) group displayed good biocompatibility and osteogenesis capabilities, which also led to an increase in alkaline phosphatase activity, extracellular matrix mineralization, and the upregulation of osteogenic genes. This research has significant implications for developing multifunctional biomaterials and clinical application.This article is protected by copyright. All rights reserved

show abstract

Self‐Assembled Multilayered Coatings with Multiple Cyclic Self‐Healing Capability, Bacteria Killing, Osteogenesis, and Angiogenesis Properties on Magnesium Alloys

Cited by 3 publications

References 61 publications

Enzymatically Driven Mineralization of a Calcium–Polyphosphate Bleaching Gel

Enzymatically Driven Mineralization of a Calcium–Polyphosphate Bleaching Gel

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

An Injectable Magnesium‐Based Cement Stimulated with NIR for Drug‐Controlled Release and Osteogenic Potential

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