Self-Assembled Monolayer-Immobilized Gold Nanoparticles as Durable, Anti-Stiction Coatings for MEMS

Hurst, Kendall M.; Ansari, N.; Roberts, Christopher B.; Ashurst, W. Robert

doi:10.1109/jmems.2011.2112334

Cited by 15 publications

(11 citation statements)

References 63 publications

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“…4a, we observed Dd p,hz ¼ 16.7 nm and Dd p,m ¼ 8.5 nm after the adsorption of anti-TNF on citrate-stabilized AuNPs. In this case, binding could occur via the cysteine or amine groups in the sequence of anti-TNF, 21,22,58,77 which is similar to other types of protein absorption on AuNPs and was not specific to the antigen binding receptors. In general, the dimensional information measured by DLS and ES-DMA in Fig.…”

Section: Anti-tnf On Tnf-conjugated Aunps (Two-component Adsorption)mentioning

confidence: 93%

Tumor necrosis factor interaction with gold nanoparticles

Tsai¹,

Elzey²,

DelRio³

et al. 2012

Nanoscale

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We report on a systematic investigation of molecular conjugation of tumor necrosis factor-α (TNF) protein onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spectroscopic characterization methods, including electrospray-differential mobility analysis, dynamic light scattering, polyacrylamide gel electrophoresis, attenuated total reflectance-Fourier transform infrared spectroscopy, fluorescence assay, and enzyme-linked immunosorbent assay. The native TNF used in this study exists in the active homotrimer configuration prior to conjugation. After binding to AuNPs, the maximum surface density of TNF is (0.09 ± 0.02) nm(-2) with a binding constant of 3 × 10(6) (mol L(-1))(-1). Dodecyl sulfate ions induce desorption of monomeric TNF from the AuNP surface, indicating a relatively weak intermolecular binding within the AuNP-bound TNF trimers. Anti-TNF binds to both TNF-conjugated and citrate-stabilized AuNPs, showing that non-specific binding is significant. Based on the number of anti-TNF molecules adsorbed, a substantially higher binding affinity was observed for the TNF-conjugated surface. The inclusion of thiolated polyethylene glycol (SH-PEG) on the AuNPs inhibits the binding of anti-TNF, and the amount of inhibition is related to the number ratio of surface bound SH-PEG to TNF and the way in which the ligands are introduced. This study highlights the challenges in quantitatively characterizing complex hybrid nanoscale conjugates, and provides insight on TNF-AuNP formation and activity.

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Section: Anti-tnf On Tnf-conjugated Aunps (Two-component Adsorption)mentioning

confidence: 93%

Tumor necrosis factor interaction with gold nanoparticles

Tsai¹,

Elzey²,

DelRio³

et al. 2012

Nanoscale

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“…15 Another way is to immobilize synthesized nanostructures on substrates with covalent interactions to form monolayers. 16 Growing nanostructures directly on surfaces with various deposition techniques (i.e. electrochemical, physical and chemical vapor deposition) or solution based methods (i.e.…”

Section: Introductionmentioning

confidence: 99%

Growth of branched gold nanoparticles on solid surfaces and their use as surface-enhanced Raman scattering substrates

et al. 2015

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“…Therefore, efficient approaches of AuNP formation on substrates are necessary to achieve excellent NP distribution. For instance, self-assembled monolayers (SAMs), physical vapor deposition, and Langmuir-Blodgett method [6][7][8][9][10][11][12] have been developed to produce AuNPs on substrates.…”

Section: Introductionmentioning

confidence: 99%

“…SAMs provide unique advantages of highly oriented self-organization and can incorporate a wide range of groups in alkyl chains and at chain terminals [6][7][8][9]. For example, Hurst et al [7] obtained a monolayer of self-assembled particles by attaching a functionalized p-aminophenyl trimethoxysilane and 3-mercaptopropyl trimethoxysilane polymer on a substrate and then dipping it in AuNP solution. NPs attached to the substrate via covalent bonds to immobilize AuNPs.…”

Section: Introductionmentioning

confidence: 99%

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Growth of gold nanoparticles using aluminum template via low-temperature hydrothermal method for memory applications

Razak

Cheong

et al. 2015

J Mater Sci: Mater Electron

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Gold nanoparticles (AuNPs) were grown on a Si(100) substrate using a sacrificial hydrothermal method on Al template prepared by direct current (DC) sputtering, followed by thermal annealing. The effect of annealing temperature on the Al template was investigated. The morphology and phases of the grown AuNPs were observed by field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD), respectively. FESEM and XRD results revealed the uniform face-centered cubic structure of AuNPs with isolated 83 nm particle size and 1.48 9 10 13 m -2 area density; these properties were considered optimum for AuNPs formed on the nonannealed sputtered Al template. The electrical properties of AuNPs embedded in polymethylsilsesquioxane (PMSSQ) as an organic dielectric layer were studied using a semiconductor characterization system. A metal-insulatorsemiconductor device with embedded AuNPs was proven to exhibit memory effects. Optimum memory properties of AuNPs embedded in PMSSQ were obtained for AuNPs grown on the non-annealed sputtered Al template with the lowest threshold voltage of 2.4 V in I-V characteristics and 34 electrons stored per AuNP in C-V measurement.

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Self-Assembled Monolayer-Immobilized Gold Nanoparticles as Durable, Anti-Stiction Coatings for MEMS

Cited by 15 publications

References 63 publications

Tumor necrosis factor interaction with gold nanoparticles

Tumor necrosis factor interaction with gold nanoparticles

Growth of branched gold nanoparticles on solid surfaces and their use as surface-enhanced Raman scattering substrates

Growth of gold nanoparticles using aluminum template via low-temperature hydrothermal method for memory applications

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