Self-assembled coronene nanofiber arrays: toward integrated organic bioelectronics for efficient isolation, detection, and recovery of cancer cells

Abstract

Integrated coronene-based nanofiber array devices for circulating tumor cell isolation, detection, and recovery through electrical stimulation.

Coronenes, Benzocoronenes and Beyond: Modern Aspects of Their Syntheses, Properties, and Applications

“…In addition, ratiometric fluorescent probes, relying on coronene, were able to detect microenvironment changes and micelle formation [198] . Furthermore, coronene nanofiber arrays were used for detection of cancer cells [199] …”

Reversible capture and release of circulating tumor cells on a three‐dimensional conductive interface to improve cell purity for gene mutation analysis

“…Studies have shown that PEDOT could be used to fabricate conducting polymer bioelectronic substrate for releasing biotargets from the substrates by electrostatic repulsion under electrostimulation. 41,[48][49][50] Here, DyLight 488-labeled goat anti-mouse IgG-functionalized PPB/CG/PCP scaffold was applied with cyclic positive voltage for electrostimulation (Figure S5) and the green fluorescence was decreased (Figure S6). Quantitative results showed that the decrease in fluorescent intensity was the greatest when swept from 0 to 1.0 V (Figure 2F).…”

Carbon Nanotube/Conducting Polymer Hybrid Nanofibers as Novel Organic Bioelectronic Interfaces for Efficient Removal of Protein-Bound Uremic Toxins

“…Bioelectronic interfaces (BEIs) play key roles in communication enhancement intervention when directly interfacing biology with electronic devices. They can facilitate electrical stimulation (ES) to manipulate cellular responses (e.g., biological phenotypes and specific gene expressions) − while also converting biological events to electronic signals for efficient readout. ,,− At present, most research into BEIs involves the application of organic π-conjugated materials {e.g., conducting polymers (CPs), − small-molecule semiconductors, − and carbon materials ,,, }. Relative to inorganic BEI materials, CP-based BEIs integrated with biology have a greater number of potential applications because of their extraordinary manufacturing flexibility, convenient mass production, low-temperature fabrication, intrinsic biocompatibility, biomimetic mechanical strength, and superior electrochemical and optical/photoelectric properties.…”

“…Relative to inorganic BEI materials, CP-based BEIs integrated with biology have a greater number of potential applications because of their extraordinary manufacturing flexibility, convenient mass production, low-temperature fabrication, intrinsic biocompatibility, biomimetic mechanical strength, and superior electrochemical and optical/photoelectric properties. Among CPs, poly­(3,4-ethylenedioxythiophene) (PEDOT)-based materials have attracted the most attention for their use in bioelectronics {e.g., organic electrochemical transistors, ,,,− organic-electronic ion pumps, ,, and biosensors/bioelectrodes , } because they allow dynamic control over charge transport phenomena, protein folding/conformational transitions, , and capture/release modulation of circulating tumor cells ,, through electrochemical doping/de-doping processes. Developments in multiwalled carbon nanotube (MWCNT)/mixed polymer nanocomposites have been of great interest for a broad range of bioelectronic applications due to their mechanical properties, blood compatibility, and unique electronic behavior. ,,− To the best of our knowledge, there have been no previous demonstrations of robust organic BEI systems for imparting ES functions into HD treatment.…”