Self-assembled collagen/hydroxyapatite composite materials

Advances in Collagen/Hydroxyapatite Composite Materials

“…2. This hypothesis is supported by FTIR data and was explained based on the spectral shifts of C-O and C=O bands in pure collagen and COLL/HA composites (Ficai et al 2009a As a result of these interactions, hydroxyapatite particles are preferentially deposited onto the collagenous support forming so-called nucleation centers. Once formed, the nucleation centers increase and can lead even to the formation of a thin film.…”

“…By short, the collagen mineralization was conducted in two stages, in order to mimic the in vivo osteosynthesis. First stage is the calcium deposition onto the collagen that takes 24 h. The second stage consists in phosphate addition leading to hydroxyapatite precipitation (Ficai et al 2009a). After 24 h, at 37 0 C and pH=9-10, the mineralization can be considered completed and the orientation process can be initiated.…”

“…The synthesis of COLL/HA composite materials with oriented structure can be induced by self-assembly, electric field orientation or by using a high magnetic field (Wu et al 2007), best results being reported by self-assembly (Ficai et al 2010c) and pulsed electric field orientation (Ficai et al 2010a). The magnetic field orientation is possible due to the magnetic anisotropy of the hydroxyapatite (Wu et al 2007).…”

Collagen - Modified Layered Silicate Biomaterials for Regenerative Medicine of Bone Tissue

“…The year 2000 could be considered as the "starting point" in this field. Research for obtaining new types of bio-nanocomposites based on collagen in solid physical forms of matrices or membranes in which inorganic components can be hydroxyapatite, biovitroceramica, TiO 2 , SiO 2 , natural layered silicate as it is or modified with hydrolysed collagen, antioxidants has developed (Ficai et al 2010a;Albu et al, 2009;Baia et al, 2008;Piticescu et al, 2008;Potarniche et al, 2010;Vuluga et al, 2007;Vuluga et al, 2008a). Organic compounds that can interact with collagen are represented by a series of biological active substances or other biocompatible polymers, their compatibility being previously tested with collagen gel or colloidal solutions.…”

Construction and Biofunction of 3‐Dimensional Self‐assembly Collagen Nanostructure on PLLA Substrate

“…2 Since collagen is the most important protein for composing body tissues, it is often selected for preparing replacement biomaterials, such as artificial skin, blood vessel and bone implant. [3][4][5] Many researchers think that the assembly behavior of protein at interface could be applied in biosensor and protein expression techniques. 2-Dimensional adsorbing behaviors and ordering structures of collagen on different polymer films, such as polystyrene PS, 6 PMMA, 7 gemini surfactant, 8,9 etc., have been studied.…”