Self-assembled block copolymer [(BenzA)-b-(PCL)] micelles to orient randomly distributed AuNPs into hollow core-shell morphology and its role as payload for nanomedicines

Amgoth, Chander; Doddapaneni, Suman Joshi D S; Dharmapuri, Gangappa; Mohan, Lakavathu

doi:10.1016/j.msec.2018.07.033

Cited by 15 publications

(15 citation statements)

References 54 publications

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“…However, tip size and magnification play a crucial role to acquire the topography of the NPs. Furthermore, for the uniform pores and consistent particle size, the shape can be optimized based on several factors such as sonication, [64,65]. solvent, pH, and concentration of the system (Figure 10).…”

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

“…The post-insertion method is used for the preparation of dendrimer nanoparticles and lipid nanocapsules (LNCs) with the chemically reactive surface. Ideally, this method has been designed for the grafting of ligands to the polymer compounds, and later it has been [64,65,69,70].…”

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

“…Interestingly, the use of immiscible systems in emulsions offers an easy phase separation and formulation of desired nanoparticles. However, a brief overview on low molecular weight and low-density polymer complexes show the significant proximity of the interface in emulsions, and this strategy can be used for the efficient production of nano-and microparticles for various applications [65,[69][70][71][72]. However, several mechanisms were proposed for the formation of nanoscale pores within the nanoparticles because of the removal of some of the BCP fragments from the network of the PCL.…”

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

“…As PCL is hydrophobic in nature, therefore BCP spheroids may be dissolved out from the PCL network structure and create the pores of the equivalent size of BCP spheroids. Moreover, as per factors appended in Figure 10, temperature change affects a lot on the pore size and morphology of nanoparticles [65,[73][74][75][76][77][78].…”

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

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Polymer Properties: Functionalization and Surface Modified Nanoparticles

Amgoth¹,

Phan²,

Murali³

et al. 2020

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

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Herein, the various polymer properties and the underlying mechanism for the functionalization and surface modification of polymer nanoparticles have been discussed. There are numerous polymer particles designed and developed for various applications. The synthesis and characterization of different types of polymers followed by the engineering of nanoparticles and capsules depend on various factors. There are too many polymerization methods approached for the development of nanoparticles with desired surface properties. The ring-opening polymerization (ROP), emulsion polymerization (EP), atom transfer radical polymerization (ATRP), and free radical micro initiation are the significant approaches for the polymerization reactions. The polymer nanoparticle functionalization and modification of their surfaces based on requirements is an essential task. The solvent concentration, pH, temperature, and sonication have played a vital role to tune the morphology of polymer nanoparticles and capsules. Different characterizations such as FTIR, NMR (1 H and 13 C), HRMS, and MALDI-TOF are used for preliminary structural and confirmations. Further, SEM, FE-SEM, TEM, AFM, BET, XRD, Raman, EDAX, TGA-DSC, DLS, and zeta potential were used for morphological and thermal properties.

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Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

Section: Morphology and Surface Patterning Of Nanoparticlesmentioning

confidence: 99%

See 2 more Smart Citations

Polymer Properties: Functionalization and Surface Modified Nanoparticles

Amgoth¹,

Phan²,

Murali³

et al. 2020

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, di-block copolymer micelles formed between benzyl alcohol and poly-ɛ-caprolactone (BenzA)-b-(PCL) assembled core-shell structures to house the particular shape of AuNPs. The pH-sensitive system was applied in the release of the anticancer drug doxorubicin hydrochloride (DOX) [81]. Another method for preparing AuNPs is with a polymer cross-linked network, where the amide groups of polyacrylamide (PAAm) acted as reductant and template.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

et al. 2019

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The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.

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Polymer‐based Nanocomposites for Biomedical Applications

Amgoth

Chen

et al. 2022

Nanomaterials and Nanotechnology in Medicine

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Self-assembled block copolymer [(BenzA)-b-(PCL)] micelles to orient randomly distributed AuNPs into hollow core-shell morphology and its role as payload for nanomedicines

Cited by 15 publications

References 54 publications

Polymer Properties: Functionalization and Surface Modified Nanoparticles

Polymer Properties: Functionalization and Surface Modified Nanoparticles

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

Polymer‐based Nanocomposites for Biomedical Applications

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