Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing

Dai, Chunhui; Lin, Zhihua; Agarwal, Kriti; Mikhael, Carol; Aich, Anupam; Gupta, Kalpna; Cho, Jeong-Hyun

doi:10.1021/acs.nanolett.0c02575

Cited by 17 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, the plasmonic nanopore serves as both a sensor and a nanofluidic channel for the active transport of molecules. [ 111 ] Another example is demonstrated by Dai et al., [ 218 ] who developed 3D metallic nanogaps on the inner surface of cylindrical walls of curved nanofluidic channels, simultaneously achieving hotspot creation and fluidic confinement (Figure 6b, top). This hybrid 3D nanocylinder shows a 22 times higher signal intensity for the SERS‐based detection of hemoglobin fingerprints compared to the corresponding 2D nanostructures (Figure 6b, bottom).…”

Section: Progress In Optofluidic Biosensorsmentioning

confidence: 99%

See 1 more Smart Citation

Trends in Nanophotonics‐Enabled Optofluidic Biosensors

Wang

Maier

Tittl

2022

Advanced Optical Materials

View full text Add to dashboard Cite

Optofluidic sensors integrate photonics with micro/nanofluidics to realize compact devices for the label‐free detection of molecules and the real‐time monitoring of dynamic surface binding events with high specificity, ultrahigh sensitivity, low detection limit, and multiplexing capability. Nanophotonic structures composed of metallic and/or dielectric building blocks excel at focusing light into ultrasmall volumes, creating enhanced electromagnetic near‐fields ideal for amplifying the molecular signal readout. Furthermore, fluidic control on small length scales enables precise tailoring of the spatial overlap between the electromagnetic hotspots and the analytes, boosting light‐matter interaction, and can be utilized to integrate advanced functionalities for the pre‐treatment of samples in real‐world‐use cases, such as purification, separation, or dilution. In this review, the authors highlight current trends in nanophotonics‐enabled optofluidic biosensors for applications in the life sciences while providing a detailed perspective on how these approaches can synergistically amplify the optical signal readout and achieve real‐time dynamic monitoring, which is crucial in biomedical assays and clinical diagnostics.

show abstract

Section: Progress In Optofluidic Biosensorsmentioning

confidence: 99%

Section: Progress In Optofluidic Biosensorsmentioning

confidence: 99%

Trends in Nanophotonics‐Enabled Optofluidic Biosensors

Wang

Maier

Tittl

2022

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Review on Microscale Sensors with 3D Engineered Structures: Fabrication and Applications

Zhang

et al. 2022

Small Methods

View full text Add to dashboard Cite

they can only perceive portion, along one or two axes, of a stimulus which is normally full of 3D space surrounding the sensors. [10,11] Another limitation is the deficient interface between the 2D sensors and target objects. For instance, health monitoring could be realized by attaching or implanting biomedical sensors to target organs or tissues of the human body. [12] However, it is difficult for traditional 2D sensors to collect accurate vital signals because they cannot conform to the 3D structure of organs or tissues. [13,14] Although this problem can be partially relieved by using flexible 2D sensors, [15] passive adaptation to target objects inevitably results in gaps. [16] Sensors with 3D structures have been developed to overcome these limitations. A 3D cubic sensor generated by selffolding has the ability to gain concentration as well as spatial information (i.e., direction and orientation) of target analytes surrounding the device. [17][18][19] Moreover, a 3D strain sensor fabricated by in situ 3D printing was observed to be compliant with the surface of a breathing porcine lung for continuous mapping of respiration-induced deformation with high 3D spatial resolution. [20] Besides full-space sensing and conformity to targets, compared to 2D counterparts, 3D sensors also possess advantages such as high sensitivity, [21] large specific surface area, [22] multimodal sensing, [23] and so forth.Despite their superiority to 2D sensors, it is challenging to fabricate a sensor with a delicate 3D configuration on a small scale because current micro-nano fabrication technologies are typically performed on planar silicon wafers. [35] Considerable efforts have been made to develop new fabrication methods for 3D sensors, which will be reviewed in this paper. According to the criterion of material quantity change, [36] these fabrication methods are divided into four categories: bulk chemical etching (subtractive manufacturing), 3D printing (additive manufacturing), molding (formative manufacturing), and stress-induced assembly (formative manufacturing), as shown in Figure 1. Basic applications or sensing functions (e.g., light, force, electricity, and chemical/gas), advanced applications (e.g., robotics, HMI, health monitoring, and tissue engineering), and strengths over 2D counterparts (high spatial resolution, multimodality, conformity, and high sensitivity) are illustrated for relevant 3D sensors. The fabrication methods and their pros and cons in generating 3D structures for various applications are summarized in Table 1. The discussions are concluded by outlining current challenges and future opportunities for 3D sensors.The intelligence of modern technologies relies on perceptual systems based on microscale sensors. However, because of the traditional top-down fabrication approaches performed on planar silicon wafers, a large proportion of existing microscale sensors have 2D structures, which severely restricts their sensing capabilities. To overcome these restrictions, over the past few decades, increasing e...

show abstract

“…Raman spectra have been widely used in many fields, such as analytical sciences [1][2][3][4], surface sciences [5][6][7], and biological sciences [8][9][10][11][12]. Surface-enhanced Raman scattering (SERS) has been widely explored because it can be used to improve the sensitivity of Raman spectra [13][14][15]. Different nanostructures, such as nanowires [16][17][18], nanorods [19][20][21], nanospheres [22,23], and nanoflowers [24][25][26], are fabricated to obtain a high enhancement effect of the Raman spectra.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Duty Cycle of Flower-like Silver Nanostructures Fabricated with a Lyotropic Liquid Crystal on the SERS Spectrum

et al. 2021

View full text Add to dashboard Cite

Surface-enhanced Raman scattering (SERS) has been widely reported to improve the sensitivity of Raman spectra. Ordinarily, the laser is focused on the sample to measure the Raman spectrum. The size of the focused light spot is comparable with that of micro-nano structures, and the number of micro-nano structures contained in the light spot area (defined as duty cycle) will severely affect the spectrum intensity. In this study, flower-like silver nanostructures were fabricated with a soft lyotropic liquid crystal template in order to investigate the effect of duty cycle. They were observed under a scanning electron microscope, and their spectrum enhancement factor was computed with the obtained Raman spectrum. Then, their duty cycles were measured using a SERS substrate at different locations. A formula was derived to represent the relation between the duty cycle of the nanoflowers and the Raman spectral intensity. This work could promote the actual applications of SERS in high-sensitivity spectrum testing.

show abstract

Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing

Cited by 17 publications

References 48 publications

Trends in Nanophotonics‐Enabled Optofluidic Biosensors

Trends in Nanophotonics‐Enabled Optofluidic Biosensors

Review on Microscale Sensors with 3D Engineered Structures: Fabrication and Applications

Effect of the Duty Cycle of Flower-like Silver Nanostructures Fabricated with a Lyotropic Liquid Crystal on the SERS Spectrum

Contact Info

Product

Resources

About