Self-assembled 3D biocompatible and bioactive layer at the macro-interface via graphene-based supermolecules

Zhou, Hongju; Cheng, Chong; Qin, Hailong; Ma, Lang; He, Chao; Nie, Shengqiang; Zhang, Xiang; Fu, Qiang; Zhao, Changsheng

doi:10.1039/c4py00136b

Cited by 55 publications

(54 citation statements)

References 70 publications

(79 reference statements)

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“…The Cu2p spectra for both samples were deconvoluted into two individual peaks by using XPS peak 41 software. The peaks at 932.6eV and 933.7 eV correspond with zero‐valent copper and cuprous oxide, respectively, (Fig. (b)–(c)) .…”

Section: Resultsmentioning

confidence: 98%

Demonstration of complete bacterial‐killing in water at a very high flow‐rate: use of a surface‐enhanced copper nanoparticle with activated carbon as a hybrid

Biswas

Bandyopadhyaya

2017

J of Chemical Tech & Biotech

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BACKGROUND To address the objective of disinfecting water, copper nanoparticles (Cu‐NPs) have been synthesized and impregnated on activated carbon (AC). This material when packed in a continuous column can potentially satisfy the need of a household‐scale water disinfection unit. RESULTS Accordingly, Cu‐NPs of 6.11 nm mean diameter were deposited in the form of discrete NPs, on plasma treated AC, with a Cu loading of 2.1 wt%, in Cu‐AC. Selective impregnation of Cu‐NPs was achieved on the external surface of plasma treated AC, as plasma treatment generates surface function groups on the AC surface. The superior qualities of the hybrid achieved complete killing of 104 CFU mL‐1 of E. coli cells in only 10 min contact, on using 8 mg mL‐1 of Cu‐AC in batch mode. A flow‐column (8 cm diameter and 25 cm height) designed on the basis of this batch contact time achieved disinfected water at a high flow rate of 4.13 L h‐1, even when operated non‐stop, over 7 days. Simultaneously, it maintained a very low steady state Cu concentration (83.7 μg L‐1) in the disinfected water, much below the permissible limit of 1000 μg L‐1 for drinking water. CONCLUSION This study achieved: (i) selective impregnation of Cu‐NPs on AC with controlled degree of oxidation; (ii) maximum flow rate of E. coli‐free drinking water in a continuously operating column, packed with Cu‐AC granules; and (iii) complete E. coli cell‐killing and Cu concentration within the permissible limit for drinking water over a very long duration. © 2017 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 98%

Demonstration of complete bacterial‐killing in water at a very high flow‐rate: use of a surface‐enhanced copper nanoparticle with activated carbon as a hybrid

Biswas

Bandyopadhyaya

2017

J of Chemical Tech & Biotech

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“…To evaluate the antithrombogenicity of the stimuli-responsive hemicellulose microgels, activated partial thromboplastin time (APTT) and thrombin time (TT) were measured by an automated blood coagulation analyzer CA-50 (Sysmex Corporation, Kobe, Japan) according to the method described in a previous report. 41 Healthy human fresh blood was collected in vacuum tubes containing sodium citrate as the anticoagulant (anticoagulant to blood ratio, 1:9 v/v), and the platelet-poor plasma (PPP) was obtained after centrifuging at 4000 rpm for 15 min. Stimuli-responsive hemicellulose microgels (10 mg/mL) were prepared in buffer solution (pH = 7.4), 5 μL suspensions and 100 μL of PPP were incubated at 37 °C for 0.5 h, and 50 μL of incubated solution was then added to the test cup, followed by the addition of 50 μL of APTT agent (Dade Actin Activated Cephaloplastin Reagent, Siemens; incubated 10 min before use).…”

Section: Methodsmentioning

confidence: 99%

In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray Drying

Zhao

Nugroho

Odelius

et al. 2015

ACS Appl. Mater. Interfaces

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Chemical cross-linking during spray drying offers the potential for green fabrication of microgels with a rapid stimuli response and good blood compatibility and provides a platform for stimuli-responsive hemicellulose microgels (SRHMGs). The cross-linking reaction occurs rapidly in situ at elevated temperature during spray drying, enabling the production of microgels in a large scale within a few minutes. The SRHMGs with an average size range of ∼1–4 μm contain O-acetyl-galactoglucomannan as a matrix and poly(acrylic acid), aniline pentamer (AP), and iron as functional additives, which are responsive to external changes in pH, electrochemical stimuli, magnetic field, or dual-stimuli. The surface morphologies, chemical compositions, charge, pH, and mechanical properties of these smart microgels were evaluated using scanning electron microscopy, IR, zeta potential measurements, pH evaluation, and quantitative nanomechanical mapping, respectively. Different oxidation states were observed when AP was introduced, as confirmed by UV spectroscopy and cyclic voltammetry. Systematic blood compatibility evaluations revealed that the SRHMGs have good blood compatibility. This bottom-up strategy to synthesize SRHMGs enables a new route to the production of smart microgels for biomedical applications.

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“…Uchman et al [51] synthesized a heparin-like amphiphilicterpolymer of poly((sulfamate-carboxylate)isoprene)-co-polystyreneco-poly(ethylene oxide) (PISC-co-PS-co-PEO) to prepare heparin-like multicompartment micelles, for which the core was consisted of discrete PISC and PS domains, and the shell was consisted of PEO. Recently, we grafted PSS onto GO through free radical polymerization [52]. The APTT was dramatically prolonged with the concentration of the PSS-g-GO from 0.5 μg/100 μL to 20 μg/100 μL, which was resulted from the increment of the sulfonic and carboxyl groups in PSS-g-GO.…”

Section: Raft Agentmentioning

confidence: 99%

Heparin-Mimicking Polymer Modified Polyethersulfone Membranes - A Mini Review

Xiang¹,

Cheng²

2014

J. Memb. Separ. Tech.

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Recent studies on the modification of polyethersulfone (PES) membranes using heparin-mimicking polymers are reviewed. The general conception of heparin-mimicking polymersis defined as the syntheticpolymers (including the biopolymer derivates and synthetic sulfated artificial polymers) with similar biologically functionalities as heparin, such as the anticoagulant, growth factor binding, and also disease mediation. In the review, heparin-mimicking polymers is briefly reviewed; then heparin-mimicking polymer modified PES membranes, including blended, coated, and grafted membranes are discussed respectively.

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Self-assembled 3D biocompatible and bioactive layer at the macro-interface via graphene-based supermolecules

Cited by 55 publications

References 70 publications

Demonstration of complete bacterial‐killing in water at a very high flow‐rate: use of a surface‐enhanced copper nanoparticle with activated carbon as a hybrid

Demonstration of complete bacterial‐killing in water at a very high flow‐rate: use of a surface‐enhanced copper nanoparticle with activated carbon as a hybrid

In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray Drying

Heparin-Mimicking Polymer Modified Polyethersulfone Membranes - A Mini Review

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