Self- and parent-reported Quality of Life 7 years after severe childhood traumatic brain injury in the Traumatisme Grave de l’Enfant cohort: associations with objective and subjective factors and outcomes

Câmara-Costa, Hugo; Opatowski, Marion; Francillette, Leila; Touré, Hanna; Brugel, Dominique; Laurent-Vannier, A.; Meyer, Philippe; Watier, Laurence; Dellatolas, Georges; Chevignard, Mathilde

doi:10.1007/s11136-019-02305-7

Cited by 23 publications

(24 citation statements)

References 55 publications

(64 reference statements)

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“…Severe pediatric TBI, defined by a Pediatric Glasgow Coma Scale (Peds-GCS) score ≤ 8 [6], is associated with long-standing neurological, neuropsychological and behavioral impairments, such as sensory-motor deficits, including hemiparesis and cerebellar dysfunction [7], and deficits in language, visual-spatial skills, processing speed, memory, attention, working memory, executive functioning and behavior regulation [8][9][10][11][12][13]. Those deficits are associated with impaired educational achievement [12,[14][15][16][17], reduced participation, and impaired quality of life in the long term [18][19][20][21].…”

Section: Results Of the Traumatisme Grave De L'enfant (Tge) Studymentioning

confidence: 99%

“…First, our findings must be considered cautiously given the small sample size, which decreased statistical power and might have prevented assessment of associations of some variables with memory function, such as pre-injury school difficulties, age at injury and parental education. Although a matched control group was included in the 7-year follow-up study (see for example [10,12,19,51,52]), this group did not perform the memory assessments, in order to reduce the burden of assessment length, and, thus, we opted not to include in the present analyses. Therefore, we relied on the robustness of the age-and gender-standardized norms of the memory assessment battery.…”

Section: Discussionmentioning

confidence: 99%

“…The present work is part of a larger prospective longitudinal study (TGE cohort), aiming at determining overall and specific outcomes following severe childhood TBI [10,12,19,47,[51][52][53][54].…”

Section: Methodsmentioning

confidence: 99%

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Memory functioning 7 years after severe childhood traumatic brain injury: Results of the Traumatisme Grave de l’Enfant study

Câmara-Costa

Viot

Francillette

et al. 2021

Journal of Neuropsychology

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Objective: to explore memory functioning 7-years after severe pediatric TBI, associated factors, and relationships with other outcomes. Method:Children aged 0-15 years (n=65), consecutively admitted over a 3-year period in a single trauma center, who survived after severe non-inflicted TBI, were included in a prospective longitudinal study. Memory assessments were performed 7-years post-injury using the Children's Memory Scale (CMS) or the Wechsler Memory Scale (WMS IV), according to age. The General Memory Score (GMS-7) was the primary outcome.Results: Thirty-seven patients were available for assessment at 7-years post-injury. Mean GMS-7 was in the low average range (M=84.9, SD=12.1). Lower GMS-7 was significantly associated with markers of higher injury severity, such as length of coma. One-year post-injury functional and disability outcomes explained 74% of the variance of GMS-7. Concurrent intellectual ability and type of ongoing education correlated strongly with GMS-7. Age at injury and parental education were not associated with memory outcome. Conclusions:Memory functioning is variable but often strongly impaired several years after severe pediatric TBI, and is mostly related to injury severity, functional outcomes measured 1year post-injury, and concomitant cognitive and educational outcomes. GMS-7 was lower at 7years than one-year post-injury, supporting the importance of long term follow-up.

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Section: Results Of the Traumatisme Grave De L'enfant (Tge) Studymentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Memory functioning 7 years after severe childhood traumatic brain injury: Results of the Traumatisme Grave de l’Enfant study

Câmara-Costa

Viot

Francillette

et al. 2021

Journal of Neuropsychology

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“…Some degree of novel hearing impairment is especially common (i.e., 30%) in children following bacterial meningitis [ 29 , 97 ]. Other common symptoms associated with pediatric brain injury include headache, nausea, pain, sleep disturbances, and fatigue [ 29 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury

Vanderlind

Demers²,

Engelson³

et al. 2022

Children

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Youth with a history of traumatic or non-traumatic acquired brain injury are at increased risk for long-lasting cognitive, emotional, behavioral, social, and physical sequelae post-injury. Such sequelae have great potential to negatively impact this population’s academic functioning. Consistently, poorer academic achievement and elevated need for educational supports have been well-documented among youth with a history of acquired brain injury. The current paper reviews the literature on neuropsychological, psychiatric, and academic outcomes of pediatric acquired brain injury. A discussion of special education law as it applies to this patient population, ongoing limitations within the field, and a proposal of solutions are also included.

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“…Severity of injury, as classified by the Glasgow Coma Scale (GCS) (17), tends to covary with persisting symptoms, with severe (GCS ≤ 8) and moderate (GCS 9-12) injuries being associated with higher degree of disability and cognitive deficit, lower academic long-term performance, persistent social impairments, reduced quality of life, and reduced societal participation (9,(18)(19)(20)(21)(22)(23)(24). Furthermore, fatigue is reported to be a substantial problem for as many as 58% to 74.6% of children with pTBI and seems to be unrelated to cause of injury, but positively associated with injury severity (25).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological Impairment, Brain Injury Symptoms, and Health-Related Quality of Life After Pediatric TBI in Oslo

et al. 2022

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Descriptions of clinical outcomes in pediatric traumatic brain injury (pTBI) in Scandinavia are sparse. The Oslo site of the European CENTER-TBI study has performed a pTBI outcome study in a hospitalized population. The main objective was to investigate neuropsychological outcomes, self- and parent-reported symptoms associated with brain injury, and quality of life in children aged 1–15 years, 5–8 months after injury. Fifty-two children were included, and 45 completed the assessments. The sample consisted of 15.4% severe, 21.2% moderate, and 63.4% mild TBI. Subjectively experienced problems with concentration and fatigue were reported by the parents of nearly half of the children. Higher brain injury symptom load was associated with lower quality of life, but was unrelated to injury severity. Group average scores of the sample on neuropsychological testing appeared unimpaired relative to normative means aside from lower performance in working memory. However, based on an impairment index (i.e., 2 or more tests being >1.5 SD below the normative mean), the presence of weak cognitive performance was evident in as many as 45.4% of the sample. Two-thirds of the sample also showed abnormally large intraindividual variability in cognitive functioning (i.e., significant WISC-IV index discrepancies). The findings highlight the need to look beyond group averages on neuropsychological testing. Utilizing an impairment index and considering intraindividual performance variability conveyed deficits that may warrant clinical follow-up. The association of brain injury symptoms with quality of life but not injury severity emphasizes the need to consider symptoms after TBI within a biopsychosocial framework.Clinical Trial Registration:ClinicalTrials.gov; identifier: NCT02210221.

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Self- and parent-reported Quality of Life 7 years after severe childhood traumatic brain injury in the Traumatisme Grave de l’Enfant cohort: associations with objective and subjective factors and outcomes

Cited by 23 publications

References 55 publications

Memory functioning 7 years after severe childhood traumatic brain injury: Results of the Traumatisme Grave de l’Enfant study

Memory functioning 7 years after severe childhood traumatic brain injury: Results of the Traumatisme Grave de l’Enfant study

Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury

Neuropsychological Impairment, Brain Injury Symptoms, and Health-Related Quality of Life After Pediatric TBI in Oslo

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