Self-aligning gas/liquid micropump

Schabmueller, C G J; Koch, Michael; Mokhtari, Mojtaba; Evans, A G R; Brunnschweiler, A.; Sehr, H.

doi:10.1088/0960-1317/12/4/313

Cited by 91 publications

(48 citation statements)

References 13 publications

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“…In the past, fluidic control included syringe pumps (11), hydrogel valves (12), gravity-driven pumps (13), evaporation-based pumps (14,15), acoustic pumps (16), gas-generationbased pumps (17,18), and centrifugal force in CD chips (19). Electrokinetic flow (20)(21)(22), thermopneumatic (23,24), pneumatic͞hydraulic (25), or mechanical (26,27) valves and pumps have a high degree of control, but require external connection lines to larger equipment for actuation. A few fully integrated and self-packaged systems (23,28) have been developed, but lack the reconfigurability inherent with numerous active valves and pumps.…”

mentioning

confidence: 99%

Computerized microfluidic cell culture using elastomeric channels and Braille displays

Zhu

Futai

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

365

312

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Computer-controlled microfluidics would advance many types of cellular assays and microscale tissue engineering studies wherever spatiotemporal changes in fluidics need to be defined. However, this goal has been elusive because of the limited availability of integrated, programmable pumps and valves. This paper demonstrates how a refreshable Braille display, with its grid of 320 vertically moving pins, can power integrated pumps and valves through localized deformations of channel networks within elastic silicone rubber. The resulting computerized fluidic control is able to switch among: (i) rapid and efficient mixing between streams, (ii) multiple laminar flows with minimal mixing between streams, and (iii) segmented plug-flow of immiscible fluids within the same channel architecture. The same control method is used to precisely seed cells, compartmentalize them into distinct subpopulations through channel reconfiguration, and culture each cell subpopulation for up to 3 weeks under perfusion. These reliable microscale cell cultures showed gradients of cellular behavior from C2C12 myoblasts along channel lengths, as well as differences in cell density of undifferentiated myoblasts and differentiation patterns, both programmable through different flow rates of serumcontaining media. This technology will allow future microscale tissue or cell studies to be more accessible, especially for highthroughput, complex, and long-term experiments. The microfluidic actuation method described is versatile and computer programmable, yet simple, well packaged, and portable enough for personal use.pump ͉ valve ͉ bioreactor ͉ mixer ͉ perfusion A dvanced microfluidic cellular assays (1-6) and microscale tissue engineering studies (7-10) would benefit from robust and convenient methods to computer-control accurate spatiotemporal patterns of microfluidic flows in arrays of fluidic networks. In the past, fluidic control included syringe pumps (11), hydrogel valves (12), gravity-driven pumps (13), evaporation-based pumps (14, 15), acoustic pumps (16), gas-generationbased pumps (17, 18), and centrifugal force in CD chips (19). Electrokinetic flow (20-22), thermopneumatic (23, 24), pneumatic͞hydraulic (25), or mechanical (26, 27) valves and pumps have a high degree of control, but require external connection lines to larger equipment for actuation. A few fully integrated and self-packaged systems (23, 28) have been developed, but lack the reconfigurability inherent with numerous active valves and pumps.Here, we report a method to precisely control fluid flow inside elastomeric capillary networks by using multiple (tens to hundreds) computer-controlled, piezoelectric, movable pins. These pins are positioned as a grid on a refreshable Braille display (e.g., F. H. Papenmeier, Schwerte, Germany), which is a tactile device used by the visually impaired to read computer text. Each pin can act as a valve and be shifted upward to push against channels contained in silicone rubber and completely shut the channel. Three sequential valves of this...

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mentioning

confidence: 99%

Computerized microfluidic cell culture using elastomeric channels and Braille displays

Zhu

Futai

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

365

312

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“…In 2002, Schabmueller, et al [22], from Britain developed a parallel-like valveless piezoelectric micro-pump with cone-shaped tubes, which shared the same pump chamber (see Fig. 30).…”

Section: Parallel Structurementioning

confidence: 99%

“…30 are synchronously driven in a parallel structure [22]. They share a same pump chamber and a same driving source.…”

Section: Brief Summarymentioning

confidence: 99%

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Advances in Valveless Piezoelectric Pump with Cone-shaped Tubes

Zhang

Wang

Huang

2017

Chin. J. Mech. Eng.

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This paper reviews the development of valveless piezoelectric pump with cone-shaped tube chronologically, which have widely potential application in biomedicine and micro-electro-mechanical systems because of its novel principles and deduces the research direction in the future. Firstly, the history of valveless piezoelectric pumps with cone-shaped tubes is reviewed and these pumps are classified into the following types: single pump with solid structure or plane structure, and combined pump with parallel structure or series structure. Furthermore, the function of each type of cone-shaped tubes and pump structures are analyzed, and new directions of potential expansion of valveless piezoelectric pumps with cone-shaped tubes are summarized and deduced. The historical argument, which is provided by the literatures, that for a valveless piezoelectric pump with cone-shaped tubes, cone angle determines the flow resistance and the flow resistance determines the flow direction. The argument is discussed in the reviewed pumps one by one, and proved to be convincing. Finally, it is deduced that bionics is pivotal in the development of valveless piezoelectric pump with cone-shaped tubes from the perspective of evolution of biological structure. This paper summarizes the current valveless piezoelectric pumps with cone-shaped tubes and points out the future development, which may provide guidance for the research of piezoelectric actuators.

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“…The assembled clamp is then placed within an oven at 80 8C for approximately 60 h, after which time the MMA has polymerized and cross-linked to the layers above and below it, resulting in an optically transparent bond between the layers. Relatively complex multi-layered fluidic circuits can be fabricated in this way, in much the same way that fluidic devices can be fabricated in silicon through both etch-fabrication with the use of patterned sacrificial masking layers, or direct laser surface micromachining followed by assembly using wafer bonding techniques such as anodic bonding [4,5].…”

Section: Assembly Of Multi-path Headermentioning

confidence: 99%

Design and construction of a micromilled fluidic device as part of a DNA biosensor

Townsend

Harris

Wenn

et al. 2008

Proceedings of the Institution of Mechanical Engineers, Part C:

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Under the Optonanogen project (EU contract IST-2001-37239), a novel biosensor has been developed, which incorporates a disposable acrylic polymethylmethacrylate (PMMA) fluidic header. This header is designed to deliver a sample to a series of chemically primed cantilevers where hybridization of target DNA sequences and resulting deflection of the cantilevers is detected optically. Two different microfluidic headers are described, which are designed to incorporate the cantilever chip and which demonstrate a novel approach to microfluidic header assembly, integration with macroscale fluidics, fluidic handling, and priming strategies. The first header facilitates the delivery of a single fluid sample to all cantilevers, whereas the second permits discrete delivery of samples to isolated cantilevers, despite all cantilevers being contained on a single chip. This second, multi-path header therefore allows simultaneous analysis of multiple samples, or multiple parallel tests on a single sample. This paper describes these headers and for the multi-path device details the design changes incorporated to ensure effective isolation of the sample including a novel valve to improve priming of the microfluidic circuit.

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Self-aligning gas/liquid micropump

Cited by 91 publications

References 13 publications

Computerized microfluidic cell culture using elastomeric channels and Braille displays

Computerized microfluidic cell culture using elastomeric channels and Braille displays

Advances in Valveless Piezoelectric Pump with Cone-shaped Tubes

Design and construction of a micromilled fluidic device as part of a DNA biosensor

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