Self-Aggregation Phenomenon of Promazine Hydrochloride Under the Influence of Sodium Cholate/Sodium Deoxycholate in Aqueous Medium

Abstract

Herein, we have examined the interaction between promazine hydrochloride (PMZ) with bile salts (sodium cholate (NaC) and sodium deoxycholate (NaDC)) at different temperature and composition using conductometric method. The cmc value of pure PMZ and bile salts were also evaluated by tensiometric method. The cmc values attained by the two methods are close to each other. Various physicochemical parameters like critical micelle concentration (cmc), ideal cmc (cmc id ), degree of dissociation of counter-ion (g), micellar mole fractions of bile salt ( Rub 1 X , Mot 1 X , Rod 1 X ), micellar mole fraction of bile salt in ideal state ( id 1 X ), interaction parameter ( m ), activity coefficients (f 1 , f 2 ), standard Gibbs free energy ( 0 m ΔG ), enthalpy ( 0 m ΔH ), entropy of micellization ( 0 m ΔS ) and excess free energy of mixing (ΔG ex ) of the mixed micelles have been evaluated and discussed in detail using Clint's, Rubingh's, Motomura's and Rodenas's models. NaDC is more efficient in decreasing the cmc of PMZ as compared to NaC because it binds strongly to PMZ ions and more decreases the head group area of drug. On the whole, this lesson Downloaded by [New York University] at 05:54 09 June 20152 might find application in the fundamental science of the physical chemistry of amphiphilic systems, in addition to in the research of drug delivery system.

Mixtures of antidepressant amphiphilic drug imipramine hydrochloride and anionic surfactant: Micellar and thermodynamic investigation

“…However, cationic IMH (drug) behaves another way from the typical surfactant. By way of temperature, IMH illustrates a peaked conduct in cmc : The cmc increases as temperature increases from 288.15 to 293.15 K, and after that, their values decrease at 298.15.15 and 303.15 K. Conduct in nonionic amphiphiles was also formerly attained by Islam and Kato, and other investigators in case of amphiphilic drugs view peak behavior in the curve of cmc temperature …”

Mixed micellization study of dodecyltrimethylammonium chloride and cetyltrimethylammonium bromide mixture in aqueous/urea medium at different temperatures: Theoretical and experimental view

“…Thermodynamic parameters provide sufficient information about the structural, environmental, and additive effect on the micellization of the amphiphiles. Thermodynamic parameters (standard Gibbs free energy of micellization [Δ G m o ]/enthalpy of micellization [Δ H m o ]/entropy of micellization [Δ S m o ]) of individual surfactants (DTAC & CTAB) and DTAC‐CTAB mixed system in H 2 O/NH 2 CONH 2 were calculated on the basis of mass action model with the help of the subsequent equations: …”

Solution properties of phenothiazine drug promazine hydrochloride with cationic hydrotropes in aqueous/electrolyte solution at different temperature

“…The obtained cmc values of pure compounds and their mixtures in different ratio and temperatures are shown in Tables in absence and presence of NaCl. The value of cmc in case of pure drug at 298.15 K was obtained to be 35.05 mmol kg −1 , which is close to earlier reported value, and value of the mhc of pure hydrotropes was also in fine agreement with the earlier accounted value . As, it is clear from the PMZ structure (Scheme ) the hydrophobic portion of PMZ monomer is small and rigid.…”