Self-Aggregation of MEGA-9 (N-Nonanoyl-N-methyl-d-glucamine) in Aqueous Medium: Physicochemistry of Interfacial and Solution Behaviors with Special Reference to Formation Energetics and Micelle Microenvironment

Abstract

Self-aggregation of MEGA-9 (N-nonanoyl-N-methyl-D-glucamine), a nonionic sugar-based surfactant, was studied with respect to the effect of salt (NaCl) and ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate) on its critical micelle concentration (cmc), aggregation number, hydrodynamic dimensions, energetics of micellization, and micellar microenvironment. Fluorimetry (both steady state and time resolved) was used to understand the microenvironments under the influence of additives. NaCl was found to decrease cmc, increase aggregation number (N), increase micellar size, and decrease enthalpy of micelle formation; the IL effect on the parameters was mostly opposite. The microscopic properties of micelles were probed using two fluorophores: one nonpolar C-153 (2,3,5,6-1H,4H-tetrahydro-8-trifluormethylquinolizino-(9,9a,1-gh)coumarin) and the other fairly polar ANS (8-anilinonaphthalene-1-sulfonate); they delivered information on the palisade layer and the peripheral region of the micelle interface, respectively. Energy of activation and entropy of activation of the dynamics of the probes were evaluated from their decay time, lifetime, and rotational movements in the regions of residency in the micelles. Density functional theory (DFT) calculations showed that the ternary combination MEGA-9/IL/H2O had the maximum interaction energy compared to any of the binary combinations. Thus, the ionic liquid reduced MEGA-9 self-association to a large extent.

Responsive Self‐Assembly of Supramolecular Hydrogel Based on Zwitterionic Liquid Asymmetric Gemini Guest

“…Density functional theory (DFT) : DFT calculations were carried out to simulate the optimum configuration of trans ‐ and cis ‐AzoIPS‐LiTFSI. The Gaussian 09 package with the B3LYP hybrid functional and the 6‐31G(d,p) basis set were used.…”

“…The Gaussian 09 [23] package with the B3LYP hybrid functional and the 6-31G(d,p) basis set were used. The Gaussian 09 [23] package with the B3LYP hybrid functional and the 6-31G(d,p) basis set were used.…”

Various salts employed as precipitant in combination with polyethylene glycol in protein/detergent particle association

“…5D and E). These large values and variations are attributable to the high density of hydroxyl groups in the hydrophilic layer of the detergent cluster in which MEGA9 molecules are tightly packed in the presence of salts such as NaCl, KNO 3 and Mg(NO 3 ) 2 [8,34].…”

Co‐assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

“…According to the calculated electrostatic potentials (Figure 4 d,e) and interaction energy with water (Supporting Information, Figure S11 and Table S1), the nitrogen atom of APE possesses stronger water interaction than the hydrogen atom of BPE. It indicated that BPE was more readily to form aggregates in water [14] . The strong aggregation ability and π–π stacking between BPE molecules may influence the interaction between water and H e , which finally contributing the formation of right‐handed helices [15] .…”