Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice

Martellotta, M.C.; Cossu, G; Fattore, Liana; Gessa, Gian Luigi; Fratta, Walter

doi:10.1016/s0306-4522(98)00052-9

Cited by 187 publications

(131 citation statements)

References 21 publications

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“…The synthetic CB 1 agonist WIN 55,212 has been reported to maintain intravenous self-administration behavior in mice and rats (Martellotta et al, 1998;Fattore et al, 2001;Navarro et al, 2001) and the synthetic CB 1 agonist HU-210 maintains intravenous self-administration behavior in mice (Navarro et al, 2001). However, these studies used experimental procedures that limited the generality of the findings.…”

Section: Self-administration Of Cannabinoids By Laboratory Animalsmentioning

confidence: 99%

“…However, these studies used experimental procedures that limited the generality of the findings. For example, in both studies with mice (Martellotta et al, 1998;Navarro et al, 2001), one-day experimental tests were used during which mice were severely restrained for acute intravenous administration through the tail vein. There is very limited information available about acquisition, extinction and relapse to drug self-administration behavior using this methodology.…”

Section: Self-administration Of Cannabinoids By Laboratory Animalsmentioning

confidence: 99%

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Self-administration of cannabinoids by experimental animals and human marijuana smokers

Justinová

Goldberg

Heishman

2005

Pharmacology Biochemistry and Behavior

115

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Drug self-administration behavior has been one of the most direct and productive approaches for studying the reinforcing effects of psychoactive drugs, which are critical in determining their abuse potential. Cannabinoids, which are usually abused by humans in the form of marijuana, have become the most frequently abused illicit class of drugs in the United States. The early elucidation of the structure and stereochemistry of delta-9-tetrahydrocannabinol (THC) in 1964, which is now recognized as the principal psychoactive ingredient in marijuana, activated cannabinoid research worldwide. This review examines advances in research on cannabinoid self-administration behavior by humans and laboratory animals. There have been numerous laboratory demonstrations of the reinforcing effects of cannabinoids in human subjects, but reliable self-administration of cannabinoids by laboratory animals has only recently been demonstrated. It has now been shown that strong and persistent self-administration behavior can be maintained in experimentally and drugnaïve squirrel monkeys by doses of THC comparable to those in marijuana smoke inhaled by humans. Furthermore, reinforcing effects of some synthetic CB 1 cannabinoid agonists have been recently reported using intravenous and intracerebroventricular self-administration procedures in rats and mice. These findings support previous conclusions that THC has a pronounced abuse liability comparable to other drugs of abuse under certain experimental conditions. Self-administration of THC by squirrel monkeys provides the most reliable animal model for human marijuana abuse available to date. This animal model now makes it possible to study the relative abuse liability of other natural and synthetic cannabinoids and to preclinically assess new therapeutic strategies for the treatment or prevention of marijuana abuse in humans.

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Section: Self-administration Of Cannabinoids By Laboratory Animalsmentioning

confidence: 99%

Section: Self-administration Of Cannabinoids By Laboratory Animalsmentioning

confidence: 99%

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Justinová

Goldberg

Heishman

2005

Pharmacology Biochemistry and Behavior

115

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“…At preclinical level, it has been now definitely established that cannabinoids act on the brain in a way similar to other drugs of abuse (Gardner, 2002), producing clear subjective effects and leading to drug-seeking and drug-taking behavior (Martellotta et al, 1998;Fattore et al, 2001Fattore et al, , 2007bJustinova et al, 2003Justinova et al, , 2005Spano et al, 2004;Fadda et al, 2006;Deiana et al, 2007). However, the eCB system is not only the primary site of action for the motivational and reinforcing properties of cannabinoids, but it also exerts an overall modulatory effect on brain reward pathways, thus participating in the addictive properties of most drugs of abuse, such as alcohol (Mechoulam and Parker, 2003), nicotine (Viveros et al, 2006;Forget et al, 2006), cocaine (Arnold, 2005), opioids (Navarro et al, 2001;Fattore et al, 2004Fattore et al, , 2005aFattore et al, , 2007dSpano et al, 2007), methamphetamine (MDMA) (Parrott, 2006), and salvinorin (Braida et al, 2007a,b).…”

Section: Cannabinoids and Drug Addictionmentioning

confidence: 99%

“…Thus, intravenous SA of THC and AEA has been demonstrated in squirrel monkeys (Justinova et al, 2003(Justinova et al, , 2005, intravenous SA of WIN 55,212-2 has been reported in drug-naive mice (Martellotta et al, 1998;Ledent et al, 1999;Fattore et al, 2002) and trained rats (Fattore et al, , 2007bSpano et al, 2004;Fadda et al, 2006;Deiana et al, 2007), while intracerebroventricular SA of CP 55,940 has been described in rats (Braida et al, 2001). Interestingly, cannabinoid SA is…”

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confidence: 98%

Neurobiological mechanisms of cannabinoid addiction

Fattore

Fadda

Spano

et al. 2008

Molecular and Cellular Endocrinology

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Please cite this article as: Fattore, L., Fadda, P., Spano, M.S., Pistis, M., Fratta, W., Neurobiological mechanisms of cannabinoid addiction, Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 2 AbstractThe endocannabinoid system is implicated in the regulation of a variety of physiological processes, among which conditioning, motivation, habit forming, memory, learning, and cognition play pivotal roles in drug reinforcement and reward. In this article we will give a synopsis of last developments in research on cannabinoid actions on brain reward circuits coming from behavioral, neurochemical and electrophysiological studies. Central cannabinoid-induced effects as measured by animal models of addiction, in vivo cerebral microdialysis, in vitro and in vivo electrophysiological recording techniques, will be reviewed.Brain sites that have been implicated in the mediation of addictive cannabinoid properties include primarily the ventral tegmental area, the nucleus accumbens, and the medial prefrontal cortex, although the amygdala, the substantia nigra, the globus pallidus, and the hippocampus have also been shown to be critical structures mediating motivational and reinforcing effects of cannabinoids. Putative neurobiological mechanisms underlying these effects will be delineated.

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“…In this regard, cannabinoids are self-administered by animals (Martellotta et al 1998;Tanda et al 2000), produce a physical withdrawal syndrome upon either cessation of drug treatment (Aceto et al 2001) or by challenge with an antagonist (Aceto et al 1995;Tsou et al 1995). Furthermore, chronic administration of cannabinoids produces a profound down regulation of cannabinoid receptors (Oviedo et al 1993;Fan et al 1996;Breivogel et al 1999).…”

Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice

Cited by 187 publications

References 21 publications

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Neurobiological mechanisms of cannabinoid addiction

Cannabis Produces Dependence: A Comment on Smith

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