“…Preclinical studies identified lead haptens designed to target fentanyl (F), carfentanil (Carf), oxycodone (Oxy), and heroin/morphine (M), whose individual lead candidate conjugate vaccines (F-CRM, Carf-CRM, Oxy-sKLH, and M-sKLH, respectively) were effective in blocking the distribution of their respective target drug to the brain and reducing their behavioral effects in mice, rats, ,− and mini-pigs . Among these conjugate vaccines, a vaccine against oxycodone (Oxy-sKLH) is currently in Phase I clinical trials (NCT04458545), while the other lead conjugate vaccines F-CRM and M-sKLH are either in the process of being manufactured or readied for upcoming clinical trials, which will include the incorporation of toll-like receptor (TLR) 7/8 agonists to enhance efficacy. ,, Throughout the remainder of this paper, the M hapten and its conjugated form, M-sKLH, will be referred to as “Her” and “Her-sKLH”, respectively, as they target heroin, 6-acetylmorphine (6-MAM), and morphine …”