Self-activation of Wnt signaling in pre-granulosa cells is required for ovarian folliculogenesis

Habara, Okiko; Logan, Cheryl A.; Kanai‐Azuma, Masami; Nusse, Roeland; Takase, Hinako M.

doi:10.1101/2020.10.20.346304

Cited by 3 publications

(5 citation statements)

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“…WNT is classified broadly into canonical β-catenin dependent, and non-canonical β-cateninindependent pathways Nusse and Clevers, 2017). The WNT signaling pathway is indispensable for primordial germ cell development, oogenesis, follicle development, and maintenance of follicular reserve (Kocer et al, 2008;Zhou et al, 2012;De Cian et al, 2020;Habara et al, 2021). Among the 19 WNT ligands, the mRNAs for Wnt4, Wnt6 and Wnt11 were experssed in the pre-granulosa cells during primordial follicle activation.…”

Section: Wnt Ligand Secretion Mediatormentioning

confidence: 99%

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Wnt Ligand Secretion Mediatormentioning

confidence: 99%

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

2024

Frontiers Research Topics

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“…WNT is classified broadly into canonical β-catenin dependent, and non-canonical β-cateninindependent pathways (Clevers and Nusse, 2012;Nusse and Clevers, 2017). The WNT signaling pathway is indispensable for primordial germ cell development, oogenesis, follicle development, and maintenance of follicular reserve (Kocer et al, 2008;Zhou et al, 2012;De Cian et al, 2020;Habara et al, 2021). Among the 19 WNT ligands, the mRNAs for Wnt4, Wnt6 and Wnt11 were experssed in the pre-granulosa cells during primordial follicle activation.…”

Section: Wnt Ligand Secretion Mediatormentioning

confidence: 99%

“…Among the 19 WNT ligands, the mRNAs for Wnt4, Wnt6 and Wnt11 were experssed in the pre-granulosa cells during primordial follicle activation. Wnt2, Wnt2b, Wnt9a, Wnt5b, Wnt11 and Wnt16 was expressed in the oocytes of primordial follicles (Habara et al, 2021). After conditional knockdown of the wntless in pre-granulosa cells, the pre-granulosa cells could not grow and differentiate into cubic granulosa cells, which leads to female infertility (Habara et al, 2021).…”

Section: Wnt Ligand Secretion Mediatormentioning

confidence: 99%

“…Wnt2, Wnt2b, Wnt9a, Wnt5b, Wnt11 and Wnt16 was expressed in the oocytes of primordial follicles (Habara et al, 2021). After conditional knockdown of the wntless in pre-granulosa cells, the pre-granulosa cells could not grow and differentiate into cubic granulosa cells, which leads to female infertility (Habara et al, 2021). Wntless in pre-granulosa cells is essential for communication between pre-granulosa cells and oocytes and primordial follicle activation.…”

Section: Wnt Ligand Secretion Mediatormentioning

confidence: 99%

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Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients

Zhang

He²,

Zhang³

et al. 2023

Front. Physiol.

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Primordial follicles are the starting point of follicular development and the basic functional unit of female reproduction. Primordial follicles are formed around birth, and most of the primordial follicles then enter a dormant state. Since primordial follicles are limited in number and can’t be renewed, dormant primordial follicles cannot be reversed once they enter the growing state. Thus, the orderly occurrence of primordial follicles selective activation directly affects the rate of follicle consumption and thus determines the length of female reproductive lifespan. Studies have found that appropriately inhibiting the activation rate of primordial follicles can effectively slow down the rate of follicle consumption, maintain fertility and delay ovarian aging. Based on the known mechanisms of primordial follicle activation, primordial follicle in vitro activation (IVA) technique has been clinically developed. IVA can help patients with premature ovarian failure, middle-aged infertile women, or infertile women due to gynecological surgery treatment to solve infertility problems. The study of the mechanism of selective activation of primordial follicles can contribute to the development of more efficient and safe IVA techniques. In this paper, recent mechanisms of primordial follicle activation and its clinical application are reviewed.

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“…It has been shown that non-canonical Wnt signals, not classical Wnt signals, are involved in the maintenance of resting phase (Sugimura et al, 2012). In primordial follicles, classical Wnt signals have been shown to act on granulosa cells and induce activation of primordial follicles (Habara et al, 2021). ISCs, which actively proliferate, use proliferation signals for their maintenance and are thought to have a different mechanism from resting stem cells and primordial follicles.…”

Section: Figurementioning

confidence: 99%

Oocyte aging in comparison to stem cells in mice

Nagamatsu

2023

Front. Aging

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To maintain homeostasis, many tissues contain stem cells that can self-renew and differentiate. Based on these functions, stem cells can reconstitute the tissue even after injury. In reproductive organs, testes have spermatogonial stem cells that generate sperm in men throughout their lifetime. However, in the ovary, oocytes enter meiosis at the embryonic stage and maintain sustainable oogenesis in the absence of stem cells. After birth, oocytes are maintained in a dormant state in the primordial follicle, which is the most premature follicle in the ovary, and some are activated to form mature oocytes. Thus, regulation of dormancy and activation of primordial follicles is critical for a sustainable ovulatory cycle and is directly related to the female reproductive cycle. However, oocyte storage is insufficient to maintain a lifelong ovulation cycle. Therefore, the ovary is one of the earliest organs to be involved in aging. Although stem cells are capable of proliferation, they typically exhibit slow cycling or dormancy. Therefore, there are some supposed similarities with oocytes in primordial follicles, not only in their steady state but also during aging. This review aims to summarise the sustainability of oogenesis and aging phenotypes compared to tissue stem cells. Finally, it focuses on the recent breakthroughs in vitro culture and discusses future prospects.

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Self-activation of Wnt signaling in pre-granulosa cells is required for ovarian folliculogenesis

Cited by 3 publications

References 59 publications

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy

Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients

Oocyte aging in comparison to stem cells in mice

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