Selenosis in Ruminants

Raisbeck, Merl F.

doi:10.1016/j.cvfa.2020.08.013

Cited by 13 publications

(8 citation statements)

References 55 publications

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“…Correcting a Se deficit, whatever the cause, needs an adequate supply, as excessive Se intake can be toxic [ 48 ]. Some observational studies and systematic analyses have reported an association between elevated Se concentrations and type 2 diabetes [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

Sun

Mehl

Renko

et al. 2021

IJMS

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The essential trace element selenium (Se) is needed for the biosynthesis of selenocysteine-containing selenoproteins, including the secreted enzyme glutathione peroxidase 3 (GPX3) and the Se-transporter selenoprotein P (SELENOP). Both are found in blood and thyroid colloid, where they serve protective functions. Serum SELENOP derives mainly from hepatocytes, whereas the kidney contributes most serum GPX3. Studies using transgenic mice indicated that renal GPX3 biosynthesis depends on Se supply by hepatic SELENOP, which is produced in protein variants with varying Se contents. Low Se status is an established risk factor for autoimmune thyroid disease, and thyroid autoimmunity generates novel autoantigens. We hypothesized that natural autoantibodies to SELENOP are prevalent in thyroid patients, impair Se transport, and negatively affect GPX3 biosynthesis. Using a newly established quantitative immunoassay, SELENOP autoantibodies were particularly prevalent in Hashimoto’s thyroiditis as compared with healthy control subjects (6.6% versus 0.3%). Serum samples rich in SELENOP autoantibodies displayed relatively high total Se and SELENOP concentrations in comparison with autoantibody-negative samples ([Se]; 85.3 vs. 77.1 µg/L, p = 0.0178, and [SELENOP]; 5.1 vs. 3.5 mg/L, p = 0.001), while GPX3 activity was low and correlated inversely to SELENOP autoantibody concentrations. In renal cells in culture, antibodies to SELENOP inhibited Se uptake. Our results indicate an impairment of SELENOP-dependent Se transport by natural SELENOP autoantibodies, suggesting that the characterization of health risk from Se deficiency may need to include autoimmunity to SELENOP as additional biomarker of Se status.

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Section: Discussionmentioning

confidence: 99%

Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

Sun

Mehl

Renko

et al. 2021

IJMS

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“…Kasus di lapangan pada sapi yang diberi pakan mengandung Selenite dan mati karena gagal jantung akan menunjukkan nekrosis dan fibrosis pada jantung (Yaeger et al, 1998;Davis et al, 2012). Meskipun telah banyak bukti bukti penelitian yang menunjukkan bahwa Selenium dapat mengakibatkan keracunan pada ternak, namun sampai saat ini, masih terjadi perdebatan tentang pathogenesis terjadinya keracunan tersebut (Raisbeck, 2020).…”

Section: Toksisitas Selenium Dan Vitamin E Pada Ternak Ruminansiaunclassified

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

Yanuartono,

Indarjulianto,

Paryuni

2024

jiiip

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Latar Belakang: Selenium (Se) adalah unsur yang umum terdapat di alam. Selenium ditemukan di dalam tanah dan diserap oleh tanaman pada tingkat yang berbeda-beda tergantung pada spesies tanaman, penggunaan pupuk, dan curah hujan, sedangkan vitamin E banyak terdapat pada tanaman leguminosa dan rumput segar. Selenium dan vitamin E merupakan elemen penting bagi ternak ruminansia dan diperlukan untuk untuk pertumbuhan normal dan membantu mencegah gangguan kesehatan lain. Peran kedua unsur tersebut memiliki kaitan yang erat karena mampu melindungi sel dari efek oksidasi yang merugikan meskipun memiliki mekanisme dengan cara yang berbeda. Kekurangan salah satu atau kedua unsur tersebut dapat menyebabkan penyakit white muscle disease, retensi plasenta, metritis, penurunan fungsi kekebalan tubuh, dan mastitis. Meskipun demikian, hasil penelitian maupun studi lapangan juga menunjukkan bahwa Se dan vitamin E dapat menimbulkan keracunan pada ruminansia. Reviews : Tulisan ini akan mengulas secara singkat dampak defisiensi dan toksisitas Se Vitamin E pada ruminansia.

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“…Approximate time of previous Se exposure (possibly up to 1-3 years previously) can be estimated by collecting mane or tail hair of horses (Figure 8) (114) or hair from a tail switch of cattle and then segmenting the hair and analyzing each segment for Se content while estimating growth rates. A similar approach to determining time and extent of exposure can be done by fragmenting and analyzing hooves for Se content (115). Acute Se poisoning is usually caused because of oversupplementation or overdosing with parenteral preparations or due to animals (most often naïve animals) consuming a toxic dose of Se-accumulator plants.…”

Section: Animal Biomarkers Of Selenium Poisoningmentioning

confidence: 99%

“…Horses are very susceptible to chronic Se poisoning with sheep being much more resistant. Raisbeck (115) had suggested that, when comparing chronic Se poisoning in livestock, the order from most sensitive to least sensitive is swine (most sensitive) > horses > cattle >sheep (least sensitive). The treatments for chronic Se poisoning are limited but removal of the source of exposure is necessary along with a low Se, high quality and high protein diet with balanced micronutrients.…”

Section: Animal Biomarkers Of Selenium Poisoningmentioning

confidence: 99%

Biomarkers and their potential for detecting livestock plant poisonings in Western North America

et al. 2023

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The United States National Cancer Institute defines a biomarker as: “A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease.” In Veterinary Medicine, biomarkers associated with plant poisonings of livestock have great utility. Since grazing livestock poisoned by toxic plants are often found dead, biomarkers of plant poisoning allow for a more rapid postmortem diagnosis and response to prevent further deaths. The presence and concentration of toxins in poisonous plants are biomarkers of risk for livestock poisoning that can be measured by the chemical analysis of plant material. More difficult is, the detection of plant toxins or biomarkers in biological samples from intoxicated or deceased animals. The purpose of this article is to review potential biomarkers of plant poisoning in grazing livestock in the Western North America including recently investigated non-invasive sampling techniques. Plants discussed include larkspur, lupine, water hemlock, swainsonine-containing plants, selenium-containing plants, and pyrrolizidine alkaloid containing plants. Other factors such as animal age and sex that affect plant biomarker concentrations in vivo are also discussed.

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Selenosis in Ruminants

Cited by 13 publications

References 55 publications

Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

Biomarkers and their potential for detecting livestock plant poisonings in Western North America

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