Selenoproteins and Protection against Oxidative Stress: Selenoprotein N as a Novel Player at the Crossroads of Redox Signaling and Calcium Homeostasis

Arbogast, Sandrine; Ferreiro, Ana

doi:10.1089/ars.2009.2890

Cited by 144 publications

(98 citation statements)

References 114 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the biological mechanism underlying a positive association between selenium and blood pressure measure is not yet fully understood, selenium's effect on oxidative stress has been investigated in animal studies. As a key component of many antioxidant enzymes, such as glutathione peroxidase (GPx) selenium plays an important role in oxidative stress [27], which is recognized as one of the fundamental mechanisms underlying hypertension [2]. An experimental study had observed that selenium at low doses can provide significant protection of the human coronary artery endothelium against damage by oxidative stress [28].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Jin

Unverzagt

et al. 2016

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Objectives:Results from previous studies have been inconsistent on the association between selenium and hypertension, and very few studies on this subject have focused on the elderly population. The purpose of this study is to examine the relationship between selenium level and hypertension in a rural elderly Chinese cohort.Design: A longitudinal study was implemented and data were analyzed using logistic regression models and Cox proportional hazards regression model adjusting for potential confounders. The association between selenium level and prevalent hypertension at baseline and between selenium and incident hypertension were examined. Setting:Community-based setting in four rural areas in China.Subjects: A total of 2000 elderly aged 65 years and over (mean 71.9±5.6 years) participated in this study.Measurements: Nail selenium levels were measured in all subjects at baseline. Blood pressure measures and self-reported hypertension history were collected at baseline, 2.5 years and 7 years later. Hypertension was defined as systolic blood pressure 140 mmHg or higher, diastolic blood pressure 90 mmHg or higher, or reported use of anti-hypertensive medication. Results:The rate of baseline hypertension was 63.50% in this cohort and the mean nail selenium level is 0.413±0.183μg/g. Multi-covariate adjusted cross-sectional analyses indicated that higher selenium level was associated with higher blood pressure measures at baseline and higher rates of hypertension. For the 635 participants with normal blood pressure at baseline, 360 had developed hypertension during follow-up. The incidence rate for hypertension was 45.83%, 52.27, 62.50%, 70.48%, and 62.79% from the first selenium quintile to the fifth quintile respectively. Comparing to the lowest quintile group, the hazard ratio were 1. for the second selenium quintile to the fifth quintile respectively. Conclusions:Our findings suggest that high selenium may play a harmful role in the development of hypertension. Future studies are needed to confirm our findings and to elucidate a plausible biological mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Jin

Unverzagt

et al. 2016

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

show abstract

“…Mutations in the human SelN gene (also known as SEPN1) are associated with a group of early-onset muscle disorders known as SEPN1-related myopathies (10). SelN is an ER-resident transmembrane glycoprotein that is highly expressed during embryonic development and to a lesser extent in adult tissues including skeletal muscle (286).…”

Section: K Selenoprotein Nmentioning

confidence: 99%

Selenoproteins: Molecular Pathways and Physiological Roles

Labunskyy

Hatfield

Gladyshev³

2014

Physiological Reviews

994

835

View full text Add to dashboard Cite

Selenium is an essential micronutrient with important functions in human health and relevance to several pathophysiological conditions. The biological effects of selenium are largely mediated by selenium-containing proteins (selenoproteins) that are present in all three domains of life. Although selenoproteins represent diverse molecular pathways and biological functions, all these proteins contain at least one selenocysteine (Sec), a seleniumcontaining amino acid, and most serve oxidoreductase functions. Sec is cotranslationally inserted into nascent polypeptide chains in response to the UGA codon, whose normal function is to terminate translation. To decode UGA as Sec, organisms evolved the Sec insertion machinery that allows incorporation of this amino acid at specific UGA codons in a process requiring a cis-acting Sec insertion sequence (SECIS) element. Although the basic mechanisms of Sec synthesis and insertion into proteins in both prokaryotes and eukaryotes have been studied in great detail, the identity and functions of many selenoproteins remain largely unknown. In the last decade, there has been significant progress in characterizing selenoproteins and selenoproteomes and understanding their physiological functions. We discuss current knowledge about how these unique proteins perform their functions at the molecular level and highlight new insights into the roles that selenoproteins play in human health.

show abstract

“…The association with Ca 2+ release links SelN to a potential function in the development of slow muscle fibers in embryos. 140 Despite its confirmed key role in muscle tissue, the specific biological function of SelN remains unknown. Paradoxically, it is the only Se-protein whose connection to a disease, SEPN1-related myopathy, has been directly established as a consequence of mutations in the SelN gene.…”

Section: Selenoprotein Rmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

607

454

View full text Add to dashboard Cite

Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

show abstract

Selenoproteins and Protection against Oxidative Stress: Selenoprotein N as a Novel Player at the Crossroads of Redox Signaling and Calcium Homeostasis

Cited by 144 publications

References 114 publications

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Longitudinal association between selenium levels and hypertension in a rural elderly Chinese cohort

Selenoproteins: Molecular Pathways and Physiological Roles

Selenium biochemistry and its role for human health

Contact Info

Product

Resources

About