Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (<i>Gallus gallus</i>)

Li, Jinlong; Li, Wei; Sun, Xuetong; Xia, Jun; Li, Xue-Nan; Lin, Jianhua; Zhang, Cong; Sun, Xiaochen; Xu, Shiwen

doi:10.18632/oncotarget.16283

Cited by 4 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selenium (Se), one of the nutritionally necessary trace elements for a large range of species, exerts a variety of biological effects including immune protection [8] and alleviation of tissue injuries [9,10], and regulates muscle metabolism and apoptosis [11,12], brain function and neuropathology [13], and reproduction [14]. Accordingly, Se deficiency can lead to pathological conditions, including reproductive disorders and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Selenium supplementation inhibits lipopolysaccharide-induced endometritis by decreasing the cholesterol content of lipid rafts

Zhao¹,

Zhu²,

Guo³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

We investigated the protective effects of selenium (Se) against lipopolysaccharide (LPS)-induced endometritis in mice. Female mice were fed Se-containing diets prior to being challenged with an intrauterine injection of LPS. Histopathological changes, expression of Toll-like receptor 4 (TLR4)-related signaling molecules and inflammatory cytokines, as well as tissue and lipid raft-associated cholesterol levels were measured in ex-vivo and in vitro experiments conducted with uterine tissues and cells. Results showed that Se reversed LPS-induced changes in uterine histopathology and decreased myeloperoxidase activity as well as levels of the pro-inflammatory cytokines TNF-α and IL-1β in excised uteri. Se supplementation also hampered LPS-induced TLR4 signaling by attenuating NF-κB and IRF3 expression, and promoted the degradation of cholesterol in both uterine tissues and lipid rafts from cultured endometrial cells. In these cells, Se also inhibited LPS-induced production of inflammatory cytokines, including TNF-α, IL-1β, and IL-6, and blocked expression of NF-κB and IRF3. These protective effects of Se were abolished by knocking down the cholesterol-sensing liver x receptor alpha (LxRα), which resulted in downregulation of the cholesterol efflux regulatory protein ABCA1. We conclude that the anti-inflammatory actions of Se against LPS-induced endometritis are associated with upregulation of the LxRα-ABCA1 pathway, leading to lipid raft destruction through cholesterol-depletion, which impedes the translocation of TLR4 to lipid rafts and blocks the ensuing inflammatory cascade.

show abstract

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Selenium supplementation inhibits lipopolysaccharide-induced endometritis by decreasing the cholesterol content of lipid rafts

Zhao¹,

Zhu²,

Guo³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

“…For the mRNA levels of TrxR, the level of SM treatment was significantly higher than the control ( p < 0.05) at the 6 h point, while both SS and SM enhanced the mRNA stability ( p < 0.05) at the 8 h point. Li et al found that 172.93 ng/mL SS treatment significantly elevated the mRNA half-life of selenophosphate synthetase in chicken embryo neurons [ 33 ]. Furthermore, 172.93 ng/mL SS was also found to elevate the mRNA half-life of selenoprotein W in chicken embryo neurons [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Selenomethionine Attenuated H2O2-Induced Oxidative Stress and Apoptosis by Nrf2 in Chicken Liver Cells

Xie,

Xu,

Ding

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Earlier studies have shown that selenomethionine (SM) supplements in broiler breeders had higher deposition in eggs, further reduced the mortality of chicken embryos, and exerted a stronger antioxidant ability in offspring than sodium selenite (SS). Since previous studies also confirmed that Se deposition in eggs was positively correlated with maternal supplementation, this study aimed to directly investigate the antioxidant activities and underlying mechanisms of SS and SM on the chicken hepatocellular carcinoma cell line (LMH). The cytotoxicity results showed that the safe concentration of SM was up to 1000 ng/mL, while SS was 100 ng/mL. In Se treatments, both SS and SM significantly elevated mRNA stability and the protein synthesis rate of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), two Se-containing antioxidant enzymes. Furthermore, SM exerted protective effects in the H2O2-induced oxidant stress model by reducing free radicals (including ROS, MDA, and NO) and elevating the activities of antioxidative enzymes, which performed better than SS. Furthermore, the results showed that cotreatment with SM significantly induced apoptosis induced by H2O2 on elevating the content of Bcl-2 and decreasing caspase-3. Moreover, investigations of the mechanism revealed that SM might exert antioxidant effects on H2O2-induced LMHs by activating the Nrf2 pathway and enhancing the activities of major antioxidant selenoenzymes downstream. These findings provide evidence for the effectiveness of SM on ameliorating H2O2-induced oxidative impairment and suggest SM has the potential to be used in the prevention or adjuvant treatment of oxidative-related impairment in poultry feeds.

show abstract

The selenocysteine toolbox: A guide to studying the 21st amino acid

Chung

Krahn

2022

Archives of Biochemistry and Biophysics

View full text Add to dashboard Cite

Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus)

Cited by 4 publications

References 56 publications

WITHDRAWN: Selenium supplementation inhibits lipopolysaccharide-induced endometritis by decreasing the cholesterol content of lipid rafts

WITHDRAWN: Selenium supplementation inhibits lipopolysaccharide-induced endometritis by decreasing the cholesterol content of lipid rafts

Selenomethionine Attenuated H2O2-Induced Oxidative Stress and Apoptosis by Nrf2 in Chicken Liver Cells

The selenocysteine toolbox: A guide to studying the 21st amino acid

Contact Info

Product

Resources

About