Seleno- and Telluro-Functionalization of Quinones: Molecules with Relevant Biological Application

Abstract

Quinones and organochalcogens are classes of compounds with great biological applicability, such as antioxidant, anticancer, anti-Alzheimer, and antidepressant activities, among others. Thus, the combination of these two classes of compounds is important to obtain new hits with biological activities that are additive or synergistic. Several methodologies for the preparation of this class of hybrid compound have been widely described. Many of the prepared hybrid molecules have shown increased biological activities and, in some cases, to act as two distinct pharmacophores. In this review, methods for the preparation of selenium-quinones, tellurium-quinones and their biological applications are highlighted.

New Charge-Transfer Complexes of Organochalcogenide Compound Based on Aryl Acetamide Group with Quinones: Synthesis, Characterization, Antioxidant, and Computational Study

“…These compounds have been found to have a high potential as bioactive structures. We believe that further research into these compounds' synthesis and biological evaluation can lead to new biochemistry tools and new successes in drug development [18][19][20][21]. da Cruz and his co-workers [22] reported Se-containing quinone based on 1,2,3-triazoles, evaluating these compounds for antitumor activity in vitro using several human cancer cell lines.…”