Selenium supplementation in pediatric patients using parenteral nutrition: Is it time to do something?

Freitas, Renata Germano Borges de Oliveira Nascimento; Nogueira, Roberto José Negrão; Hessel, Gabriel

doi:10.1590/1806-9282.64.03.217

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…24 Forty-five preterm infants (n = 77; 58.4%) and 10 term infants (n = 25; 40%) were deficient of selenium. Like previous studies, 18,19 selenium deficiency tended to be higher in preterm infants (P = .108). The supply of selenium from the mother to the fetus increases in the third trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 79%

“…Several previous studies showed that a supply of 1.34-3 mcg/kg/day of selenium is insufficient for infants, especially preterm infants. 6,18,19,36,37 According to Darlow et al, 15 whose study was the basis for the revised the European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines, the plasma selenium level of very lowbirth-weight infants (VLBWIs) supplemented with 7 mcg/kg/day of selenium as PN can increase to healthy term infants' plasma selenium levels. The study of Darlow et al 15 was conducted in New Zealand, where selenium concentrations are lower than in other regions.…”

Section: Discussionmentioning

confidence: 99%

“…However, several studies indicate that a supply of 2 mcg/kg/day of selenium is insufficient for infants, especially for preterm infants 18,19 . Also, recent guidelines suggest increasing the target supply of selenium 20–22 …”

Section: Introductionmentioning

confidence: 99%

“…17 However, several studies indicate that a supply of 2 mcg/kg/day of selenium is insufficient for infants, especially for preterm infants. 18,19 Also, recent guidelines suggest increasing the target supply of selenium. [20][21][22] Until now, most studies regarding selenium in South Korea have been conducted with adults, with few studies about selenium in neonates and infants.…”

Section: Introductionmentioning

confidence: 99%

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Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Lee

Shin

Bae

et al. 2021

J Parenter Enteral Nutr

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Background:The risk of selenium deficiency increases for infants receiving long-term parenteral nutrition (PN). This study analyzed selenium deficiency in neonates and infants requiring long-term PN and evaluated the effect of intravenous (IV) selenium provision. Methods:This study was a retrospective study of neonates and infants who were admitted to a neonatal intensive care unit from January 2010 to December 2019, received PN for ≥2 weeks, and had their serum selenium concentration measured.Patients were divided into two groups, depending on their serum selenium concentration, a deficient group (n = 55) and a nondeficient group (n = 47).Results: Of the study participants, 53.9% (55 of 102) were deficient in selenium. No difference in demographic and clinical characteristics existed except bronchopulmonary dysplasia. A subgroup analysis was performed for patients (n = 29). The average dose of IV selenium administered to patients was 2.7 ± 1.0 mcg/kg/day. The average initial serum selenium concentration was 36.5 ± 18.0 mcg/L, and the serum concentration significantly increased to 52.5 ± 19.1 mcg/L after IV selenium administration (P < .001).The correlation between the average IV selenium dose and the change in serum selenium concentrations was statistically significant (r = .423; P = .022). Conclusion:Selenium deficiency is common in neonates and infants receiving longterm PN. Serum selenium concentration increased proportionally as the IV selenium dose increased. Therefore, it is recommended to supply a proper dose of IV selenium depending on the degree of selenium deficiency.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Lee

Shin

Bae

et al. 2021

J Parenter Enteral Nutr

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“…Selenium deficiency in infants most commonly occurs in preterm infants [10,11], in whom the storage capacity of selenium in the liver is limited compared to that of term ACNM infants. In addition, selenium is depleted quickly with rapid growth [12].…”

Section: Introductionmentioning

confidence: 99%

Selenium deficiency and supplementation in infants: a narrative review

Lee

Kang

Kim

et al. 2023

Ann Clin Nutr Metab

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Purpose: This review aims to provide an overview of the factors and clinical outcomes associated with selenium deficiency and the guidelines on the optimal selenium supplementation in infants. Current concept: Selenium is a cofactor required to maintain the activity of glutathione peroxidase and is an essential trace element in the human body. Selenium is involved in many stages of oxidative injury within the human body. In severe cases, selenium deficiency may lead to cardiomyopathy. Particularly in infants, the risk factors for selenium deficiency are preterm birth and long-term parenteral nutrition. Several studies have been conducted on the relationship between selenium deficiency and bronchopulmonary dysplasia, retinopathy of prematurity, and sepsis, all of which are common diseases in preterm infants. In the past, 2-3 mcg/kg/day of intravenous selenium supplementation was recommended in preterm infants with selenium deficiency. However, recent studies have suggested that only 2-3 mcg/kg/day can prevent further decreases of selenium level in the blood of preterm infants, and that higher supplementation of 1.5-4.5 mcg/kg/day or 7 mcg/kg/day is necessary to reach the level of healthy infants at term. The recommended dose of selenium through enteral nutrition for preterm infants is 1.3-4.5 mcg/kg/day or 5-10 mcg/kg/day, depending on the guideline. Conclusion: Adequate selenium administration is required for adequate nutritional support in infants to prevent selenium deficiency, and more studies should be conducted to establish dosing guidelines considering risk factors in preterm infants.

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Selenium supplementation decreases CRP and IL-6 and increases TNF-alpha: A systematic review and meta-analysis of randomized controlled trials

Gholizadeh

Khalili

Roodi

et al. 2023

Journal of Trace Elements in Medicine and Biology

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Selenium supplementation in pediatric patients using parenteral nutrition: Is it time to do something?

Abstract: Lower plasma selenium levels have been detected since the start of the research and supplementation (2 µg/kg/day of selenous acid) was not to enough to approach the reference values.

Cited by 4 publications

References 24 publications

Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Selenium deficiency and supplementation in infants: a narrative review

Selenium supplementation decreases CRP and IL-6 and increases TNF-alpha: A systematic review and meta-analysis of randomized controlled trials

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