Selenium Supplementation and the Incidence of Preeclampsia in Pregnant Iranian Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Tara, Fatemeh; Maamouri, Gholamali; Rayman, Margaret P.; Ghayour‐Mobarhan, Majid; Sahebkar, Amirhossein; Yazarlu, Omid; Ouladan, Shaida; Tavallaie, Shima; Azimi‐Nezhad, Mohsen; Shakeri, Mohammad Taghi; Boskabadi, Hassan; Oladi, Mohammadreza; Sangani, Maryam Teimoori; Razavi, Behjat S.; Ferns, Gordon A.

doi:10.1016/s1028-4559(10)60038-1

Cited by 71 publications

(30 citation statements)

References 39 publications

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“…Dietary selenium intake or supplementation has been related to higher antioxidant enzymatic activity and lower lipid peroxidation. In contrast, selenium deficiency leads to a decline in tissue levels of selenium-dependent antioxidant enzymes and thereby oxidative stress conditions develop (9). Several authors have indicated that supplementation with n-3 LCPUFA enhanced oxidative stress at dietary intakes higher than that contained in the fish supplied in our study (the equivalent of about 500 mg/day).…”

mentioning

confidence: 56%

Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?

García-Rodríguez

Mesa

Olza

et al. 2012

Antioxidants & Redox Signaling

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Salmon is a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, could affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women. The Salmon in Pregnancy Study provided two meals of salmon per week to pregnant women from week 20 of gestation; the control group maintained their habitual diet low in oily fish. Higher selenium and retinol plasma concentrations were observed after dietary salmon supplementation. Besides, a concomitant increase in selenium and glutathione concentration as well as glutathione peroxidase and reductase activities were detected as pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy. Clinical trials identifier NCT00801502.

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mentioning

confidence: 56%

Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?

García-Rodríguez

Mesa

Olza

et al. 2012

Antioxidants & Redox Signaling

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“…Placebo controlled clinical trials also increase the fertility of men living in low selenium areas leading to successful conception [71]. Dietary selenium also reduces pre-labor membrane rupture and preeclampsia [72,73]. …”

Section: Clinical Studies With Dietary Seleniummentioning

confidence: 99%

Dietary selenium and selenoprotein function

2012

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SummarySelenium is a trace mineral and an essential nutrient in the human diet. Selenium is found in soil and water and consequently enters the food chain through the root ways of plants and aquatic organisms. Some areas of the world are low in soil selenium resulting in a selenium deficient population and the appearance of an associated heart disease and bone disorders that can be corrected with dietary selenium. Indeed the requirement for dietary selenium was established by these observations and while selenium deficiency is rare in the West, patients requiring long-term intravenous feedings have also show heart disease associated with a deficiency of selenium in the feeding fluids. Subsequently, it has been established that dietary selenium can improve a wide range of human health conditions even in areas with soil replete in selenium.

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“…Limited trials have been conducted to test the effectiveness of selenium supplementation in preventing complications of pregnancy [39,40]. The recently published SPRINT (Se in PRegnancy INTervention) trial examined biochemical markers associated with the development of pre-eclampsia and found a significant reduction in soluble fms-like tyrosine kinase-1 (sFLT-1) in women treated with selenium [40].…”

Section: Discussionmentioning

confidence: 99%

Selenium supplementation induces mitochondrial biogenesis in trophoblasts

et al. 2015

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Selenium Supplementation and the Incidence of Preeclampsia in Pregnant Iranian Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Abstract: Our findings indicate that selenium supplementation in pregnant women may be associated with a lower frequency of preeclampsia.

Cited by 71 publications

References 39 publications

Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?

Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?

Dietary selenium and selenoprotein function

Selenium supplementation induces mitochondrial biogenesis in trophoblasts

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