Selenium Status of Very Low Birth Weight Infants

Friel, James K.; Andrews, Wayne; Long, David R.; L’Abbé, Mary R.

doi:10.1203/00006450-199309000-00010

Cited by 31 publications

(16 citation statements)

References 19 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two measures of selenium status, Se-dependent glutathione peroxidase activity and erythrocyte selenium, have previously been found to be higher in female compared with male preterm infants 30 31. Red blood cell and whole blood selenium levels are indicative of selenium status over a longer time than plasma selenium values 22.…”

Section: Discussionmentioning

confidence: 94%

Zinc, copper, selenium and manganese blood levels in preterm infants

Marriott

Foote

Kimber

et al. 2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

Objective: To measure the zinc, copper, selenium and manganese blood levels in a cohort of 68 preterm infants, and to establish any associations with growth and/or dietary intake. Design: Blood samples were collected at an infant's expected date of delivery (term) and 6 months later. Serum zinc, plasma copper and whole blood manganese were analysed by atomic absorption spectrometry, plasma and red cell selenium were determined by mass spectrometry. Growth and dietary intake determinations have been previously published. Setting: Hampshire, England. Results: Mean (SD) birth weight of the infants was 1.47 (0.434) kg and mean gestation was 31.4 (2.9) weeks. Mean blood levels at term and 6 months were: serum zinc 12.0 (2.6) mmol/l and 13.8 (2.5) mmol/l; plasma copper 10.1 (2.6) mmol/l and 19.2 (3.6) mmol/l; plasma selenium 0.49 (0.15) mmol/l and 0.72 (0.14) mmol/l; red blood cell selenium 1.68 (0.40) mmol/l and 1.33 (0.19) mmol/l; and blood manganese 320 (189) nmol/l and 211 (68) nmol/l, respectively. There were no significant associations between levels of zinc and copper and dietary intakes of those nutrients at either age (dietary intakes of selenium and manganese were not determined). Only copper levels at term were significantly associated (r = 0.31; p = 0.05) with a growth parameter (head circumference). Conclusion: These results provide new information about trace element status in this vulnerable population.T race elements are essential nutrients for metabolism, growth, and neurological and immunological function. [1][2][3] Zinc is an important micronutrient that supports normal growth.2 Preterm infants are especially vulnerable to zinc deficiency.4 5 Selenium is an essential component of selenoproteins including the antioxidant glutathione peroxidase. At birth, blood levels of selenium are lower in preterm infants than in term infants and continue to fall until weaning is commenced. [6][7][8] Copper is a cofactor in several metalloproteins, essential for oxidative metabolism, myelination and the metabolism of several steroid hormones. 2Clinical copper deficiency is a recognised hazard among preterm infants. 9Manganese is an essential micronutrient component of several enzymes including pyruvate carboxylase, mitochondrial superoxide dismutase and enzymatic systems of matrix turnover in skeletal growth.10 11 The measurement of the variation in trace element blood levels in preterm infants throughout infancy, and the range of levels associated with good development are important areas of research.We have previously reported a randomised clinical trial of a specially devised nutritional strategy in preterm infants.12 The trial aimed to analyse blood mineral levels at term (expected date of delivery) and 6 months' gestation corrected age (GCA), and assess dietary intake and growth at these ages. As we did not find any significant differences in the blood levels of trace elements in the two arms of the trial, in this paper we report on the combined results of all infants enrolled in the trial to provide informati...

show abstract

Section: Discussionmentioning

confidence: 94%

Zinc, copper, selenium and manganese blood levels in preterm infants

Marriott

Foote

Kimber

et al. 2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

show abstract

“…23 Premature infants are at an increased risk for selenium deficiency for a number of reasons, including limited selenium stores created during shortened gestation, a lengthened period of rapid growth, and possibly decreased selenium absorption in the early neonatal period. [12][13][14] It has been estimated that selenium retention in vitro is 1 g/kg per day, 14 and this must be taken into account when determining the optimal selenium supplementation in the preterm infant. The ELBW preterm population is at an even higher risk, because the previous risk factors are augmented with decreasing gestational age.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Inadequate selenium stores due to decreased gestational age and an extended period of rapid growth contribute to an increased risk of selenium deficiency in the preterm infant. [12][13][14] In extremely low birth weight (ELBW) infants, respiratory distress syndrome and other conditions that cause increased nutritional requirements compound these problems. Current guidelines for selenium supplementation are 2 g/kg per day in the preterm population, 12 but these recommendations may be inadequate.…”

mentioning

confidence: 99%

Parenteral Selenium Supplementation in Extremely Low Birth Weight Infants: Inadequate Dosage But No Correlation With Hypothyroidism

et al. 1999

View full text Add to dashboard Cite

“…In formula-fed preterm infants a gender-related effect on Se metabolism was reported by Friel et al (1993). In Poland, a gender-linked hormonal response to concomitant Se and I deficiency in older children (7 -16 years) with goitre was reported by Zagrodzki et al (2000).…”

Section: Selenium Interactions and Breast-feedingmentioning

confidence: 99%

Selenium and breast-feeding

Dórea

2002

Br J Nutr

View full text Add to dashboard Cite

The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and selenoamino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4 -32 % total Se) . selenocystamine . selenocystine . selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 mg/l in colostrum (0 -5 d), transitional milk (6 -21 d), mature milk (1 -3 months) and late lactation (.5 months) respectively. Se recommendations for infants are presently not achieved in 30 % of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

show abstract

Selenium Status of Very Low Birth Weight Infants

Cited by 31 publications

References 19 publications

Zinc, copper, selenium and manganese blood levels in preterm infants

Zinc, copper, selenium and manganese blood levels in preterm infants

Parenteral Selenium Supplementation in Extremely Low Birth Weight Infants: Inadequate Dosage But No Correlation With Hypothyroidism

Selenium and breast-feeding

Contact Info

Product

Resources

About