Selenium status of a group of Scottish adults

Shortt, C.; Duthie, Garry G.; Robertson, Janet; Morrice, Philip C.; Nicol, Fergus; Arthur, John R.

doi:10.1038/sj.ejcn.1600421

Cited by 49 publications

(27 citation statements)

References 26 publications

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“…a mean level of 60 mcg/L was found in a recent Scottish study. 19 Baum showed that low plasma Se is a significantly greater risk factor for mortality than low helper T-cell count, by a factor of 16, and confers a much more significant risk than deficiency of any other nutrient investigated. In HIV-infected children, low levels of plasma Se were significantly and independently related to mortality (RR 5.96, 95%CI 1.32-26.81; P = 0.02) and faster disease progression.…”

Section: Viral Infectionmentioning

confidence: 99%

The importance of selenium to human health

2000

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Section: Viral Infectionmentioning

confidence: 99%

The importance of selenium to human health

2000

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“…Se deficiency is defined by Baum et al (1997) as a plasma level <85(0.g/l, a level not attained in many northern European countries (see p. 210), e.g. a mean level of 60 |xg/l was found in a Scottish study (Shortt et al 1997). Baum et al (1997) showed that low plasma Se was significantly associated with mortality (relative risk 10-8, P < 0002), and conferred a much more significant risk than a low helper T-cell count or deficiency of any other nutrient investigated.…”

Section: Viral Infectionsmentioning

confidence: 99%

The argument for increasing selenium intake

2002

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The essential trace mineral, Se, is of fundamental importance to human health. As a constituent of selenoproteins it plays both structural and enzymic roles, in the latter context being best known as an antioxidant and catalyst for the production of active thyroid hormone. While Se-deficiency diseases have been recognised for some time, evidence is mounting that less-overt deficiency can also cause adverse health effects and furthermore, that supra-nutritional levels of Se may give additional protection from disease. In the context of these effects, low or diminishing Se status in some parts of the world, notably in some European countries such as the UK, is giving cause for concern. While deficiency has an adverse effect on immunocompetence, Se supplementation appears to enhance the immune response. Se appears to be a key nutrient in counteracting certain viral infections; thus, in a Se-deficient host the benign coxsackie virus becomes virulent, causing heart damage, the influenza virus causes more serious lung pathology and HIV infection progresses more rapidly to AIDS. Long recognised as essential for successful animal reproduction, Se is required for human sperm maturation and sperm motility and may reduce the risk of miscarriage. Deficiency has been linked to adverse mood states. Findings have been equivocal in linking Se to cardiovascular disease risk, although other conditions involving oxidative stress and inflammation have shown some association with Se status. There is growing evidence that higher Se intakes are associated with reduced cancer risk. While persuasive evidence already exists to suggest that additional Se would be beneficial in some health conditions, results from intervention trials underway or planned have the potential to reinforce or refute the argument for increasing Se intake.

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“…In plasma only a small amount of Se is incorporated into GSH-Px. Nevertheless, some authors [4] found a positive and significant correlation (r = 0.29; p ! 0.05) between plasma Se and plasma GSH-Px of healthy subjects.…”

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confidence: 99%